Alexandria University

An experimental study of the optimum position of the drainage gallery beneath concrete gravity dam

Abstract A gravity dam relies primarily on its self-weight for stability, making the control of uplift pressure beneath the foundation essential. This study experimentally investigates the optimal horizontal and vertical placement of a drainage gallery using a Hele–Shaw model con...

Carotid plaque burden and hemodynamic alterations are associated with domain-specific cognitive impairment in community-dwelling older adults

Abstract Carotid atherosclerosis has been linked to cognitive decline, but evidence regarding its association with domain-specific cognitive performance in understudied non-Western populations remains limited. We investigated the associations of carotid plaque burden and hemodyna...

A compilation of global bio-optical in situ data for ocean-colour satellite applications – version four

Abstract. A global in situ dataset for validation of satellite products from the ESA Ocean Colour Climate Change Initiative (OC-CCI) is presented. This version of the compilation, with data starting in 1996, extends to 2025, which is important for the validation of recent algorit...

Biogenic synthesis and characterization of selenium nanoparticles by halotolerant Bacillus sonorensis 2MNHR

Abstract Selenium nanoparticles (SeNPs) have attracted significant attention owing to their unique physicochemical properties and promising biomedical applications. In the present study, a newly isolated halotolerant marine Bacillus sonorensis 2MNHR strain was employed for the ex...

Eucalyptus camaldulensis leaf extract enhances thalidomide efficacy in acute myeloid leukemia cells through modulation of mitochondrial energetics

Abstract Background Acute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by high relapse rates and poor prognosis. Leukemic stem cells (LSCs), a major driver of therapy resistance, rely predominantly on mitochondrial oxidative phosphorylation (OXPH...

Evaluation of the new Egyptian undergraduate medical program from the perspectives of faculty and institutional leadership: a nationwide, mixed-method study

Abstract Background In response to global calls for medical education reform, Egypt restructured its national undergraduate medical education program from a 6 + 1 model to a competency-based “5 + 2” model. This reformed program emphasizes early clinical exposure, integration of b...

Macro-scale cortical thickness homogeneity in Alzheimer’s disease evaluated across 11,382 structural MRI scans from two independent cohorts

Alzheimer’s disease (AD) is characterized by progressive, regionally heterogeneous cortical atrophy. Whether whole-brain cortical thickness homogeneity serves as an informative macro-scale marker of this structural disruption remains unclear. This study evaluated cortical thickne...

Comparative study of natural rubber and styrene-butadiene rubber blends reinforced with different carbon black grades for tire tread production

In this study, the effect of carbon black (CB) on the properties of natural rubber (NR) and styrene-butadiene rubber (SBR) blends were investigated. Carbon black with different grades, N330 and N550, was used as a reinforcing filler of NR/SBR blends. The rubber compounds were pre...

A machine learning approach to predict treatment response in myofascial pain patients receiving masseter trigger point injections

BACKGROUND: Trigger point injection (TPI) therapy is widely used for masseter myofascial pain syndrome (MPS), yet outcomes vary substantially. Individualized prediction tools are lacking, often leading to trial-and-error treatment selection. OBJECTIVE: To develop, externally vali...

Escherichia coli DH5α-loaded fenugreek extract: an effective anticancer combination against human breast cancer cell lines

Breast cancer is the most frequently diagnosed cancer in women and remains a leading cause of cancer-related mortality worldwide. Recently, bacteria-based delivery systems have emerged as promising strategies for targeted cancer therapy due to their biocompatibility, low systemic...

Assessing faculty knowledge, attitudes, practices, and training needs regarding artificial intelligence in medical education

Artificial intelligence (AI) is rapidly transforming healthcare, medical education, and scientific research. As AI integration into medical education becomes inevitable, faculty development programs are needed to equip medical educators with the necessary knowledge, skills, and a...

Growth-promoting influence of selenium nanoparticles and ulvan derived from Ulva lactuca on the growth of maize during the seedling stage

Abstract Marine algae contain a vast array of bioactive molecules with diverse uses. One of their interests is to apply seaweed-derived nanoparticles or polysaccharides as bio-stimulants of seed germination for plant growth promotion. Two products derived from the green alga Ulva...

Machine learning-based prediction of SARS-CoV-2 bioactivity: integrating IC50 regression and activity classification using multi-task neural networks

Abstract Accurate prediction of compound bioactivity is essential for accelerating antiviral drug discovery and reducing experimental costs. Machine learning (ML) methods have shown considerable promise in modeling structure–activity relationships and compound potency. In this st...

Novel gas tungsten powder filler metal arc welding process

Abstract In the present investigation, an innovative and patented welding process referred to as gas tungsten powder filler metal arc welding (GTPFAW) has been developed, utilizing a micro powder mixture as a filler metal in lieu of conventional welding wires. This approach prese...

Accuracy of Artificial Intelligence based chatbots in reporting jaw lesions from multimodal radiographic images: A cross-sectional study

OBJECTIVES: The current study aimed to quantify the diagnostic accuracy of commonly utilized chatbots including Gemini, Copilot, Claude, and specialized architectures like Manus in the detection and differential diagnosis of various jaw lesions, while concurrently evaluating the...

The potential therapeutic effect of quercetin on mitochondrial dysfunction in hepatorenal toxicity induced by aluminum chloride in an experimental rat model

Aluminum is a xenobiotic element known to induce hepatorenal toxicity through mechanisms involving mitochondrial dysfunction, oxidative stress, and inflammation. Quercetin, a dietary flavonoid with potent antioxidant and anti-inflammatory properties, has shown promise as a therap...