Air Force Medical University

Ganoderma Lucidum Polysaccharides Potentiate Low‐Dose Gemcitabine Against 4T1 Breast Tumors, Associated With Immune Activation and Gut Microbiota Remodeling

ABSTRACT Gemcitabine (GEM), a first‐line chemotherapeutic agent, may fail to prevent recurrence in some settings. Traditional Chinese medicine emphasizes Yin–Yang balance and “fuzheng” approaches and may offer complementary strategies. Ganoderma lucidum polysaccharides (GLP) exhi...

Hydrogen-bonded organic framework-reinforced piezoelectric scaffolds for guided in situ bone regeneration

The fibrin network formed during the early bone repair establishes a viscoelastic micromechanical niche that recruits cells and releases cytokines, playing a pivotal role in primary callus formation. However, conventional metallic implants often lack these dynamic, bioactive cues...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...

Metabolic Syndrome in Adults with HIV on Antiretroviral Therapy: Risk Factors and a Predictive Model

Background: Metabolic syndrome (MetS) is common among people living with HIV, especially those receiving long-term antiretroviral therapy (ART). This study aimed to identify risk factors for MetS in adults with HIV receiving ART and to develop a predictive nomogram. Methods: This...

The evolution of research paradigms in cancer research in China within the framework of holistic integrative medicine

The traditional medical model has driven significant advances in oncology research; however, its excessive focus on molecular details, which hinders a holistic understanding of patients, has become increasingly evident as a limitation. As an emerging medical paradigm, holistic in...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

ABSTRACT Titanium alloy scaffolds (Ti–6Al–4 V) are widely used to repair bone defects. However, conventional titanium‐based implants lack customized functional surface interfaces that promote coordinated local nerve and blood vessel regeneration, thereby limiting bone regeneratio...

Tumor-intrinsic SIRPα drives anti-PD-1 resistance in esophageal cancer by coordinating proliferative dominance and T-cell exhaustion: A target for combinatorial immunotherapy

Signal regulatory protein alpha (SIRPα) is a novel immune checkpoint protein. However, the role and mechanism of SIRPα in esophageal cancer (ESCA) remain unclear. This study explores the role of tumor intrinsic SIRPα in ESCA. Twenty-one ESCA samples treated or not with anti-progr...

Adaptive Approach Strategy for Efficient Scanning Ion Conductance Microscopy Based on Non-monotonic Approach Curves

Abstract Scanning ion conductance microscopy (SICM) enables high-resolution, noncontact, in situ characterization of specimens in liquid environments, providing simultaneous access to three-dimensional (3D) topographical, electrical, and mechanical properties. Despite its versati...

Preoperative renin-angiotensin system inhibitor management and acute kidney injury after cardiac surgery: a systematic review and meta-analysis

The optimal management of renin-angiotensin system inhibitors (RASIs) before cardiac surgery remains uncertain. Recommendations regarding continuation and preoperative temporary withholding and discontinuation differ, and the comparative effects of specific withdrawal timings on...

Dentoalveolar surgery education in Chinese undergraduate dental schools: a national survey of curriculum structure, simulation training and assessment

Dentoalveolar surgery is a core component of undergraduate dental education; however, evidence regarding its implementation in Chinese dental schools remains limited. This study investigated curriculum structure, teaching methods, simulation training, and assessment strategies fo...

Development and internal validation of a prediction model for early anastomotic leak after minimally invasive esophagectomy: a prospective cohort study

Background Anastomotic leak (AL) remains a complication after minimally invasive esophagectomy (MIE), affecting 10–20% of patients and increasing morbidity and mortality. Although local conduit perfusion and systemic nutritional status are central to anastomotic healing, no valid...

Impact of Sievers morphology on fibro-calcific remodeling in severe bicuspid aortic valve stenosis: Exploratory findings from sex-stratified analyses

Abstract Aims Aortic stenosis (AS) is the most frequent valvular complication of bicuspid aortic valve (BAV), characterized by progressive fibro-calcific remodeling of the valve leaflets, but whether Sievers morphology (type 0 vs. type 1) influences tissue composition and whether...

Indole-3-propionic acid is an endogenic agonist of hypoxia-inducible factor-1α to protect the heart against hypoxia

Abstract Tryptophan catabolism by the gut microbiota is increasingly recognized as a hub connecting environmental challenges to cardiovascular health. By systematically profiling tryptophan metabolites in humans who had moved from low altitude to an altitude of 4300 m and in mice...

Research on an Interpretable Grey Wolf Optimization-Based Ensemble Machine Learning Model for Identifying Heterogeneity of Bladder Cancer Based on Immunological Microenvironment

Abstract Bladder urothelial carcinoma (BLCA) exhibits marked heterogeneity, leading to variable treatment responses and prognoses across subtypes. Current molecular classification systems lack emphasis on immune-related genes, limiting their utility for guiding immunotherapy. Usi...

Detecting cognitive motor dissociation in unresponsive brain-injured patients: a prospective cohort study using active task-based EEG

This study aimed to assess the prevalence and prognostic value of cognitive motor dissociation (CMD) detected by active task-based electroencephalography (EEG) in a cohort of patients with disorders of consciousness (DoC). In a prospective cohort study, we enrolled 56 consecutive...

Hardware–Algorithm Co-Optimization of Weight-Update Protocols in Oxide-Based Synaptic Transistor Arrays for Neuromorphic Systems

The transition from single-device characterization to array-level simulation remains a critical challenge in the development of three-terminal synaptic transistors for neuromorphic computing, as most existing simulation studies either extract parameters from a single representati...

A Novel Photo-Responsive and Platelet-Compatible Strategy Based on Fe3O4-QCS-PEI-Cu and Aptamer for Targeted Inactivation of Bacterial Contaminants in Platelets

Bacterial contamination remains a critical safety concern in platelet transfusion, and there is an urgent demand for decontamination technologies that eliminate contaminating bacteria without damaging platelet viability and physiological function. Herein, Fe3O4-QCS-PEI-Cu-apt mic...

Combined Hyaluronic Acid and Collagen Injections for Perioral Rejuvenation: A Randomized Controlled Trial

ABSTRACT Background The perioral region, a critical facial aesthetic subunit, undergoes age‐related changes addressed primarily through dermal fillers. Optimal rejuvenation requires tailored approaches integrating anatomical precision, filler physicochemical properties, and stand...

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Pathological cartilage calcification represents a pivotal pathological alteration in osteoarthritis (OA), yet its underlying mechanisms remain poorly understood. Exosomes are involved in facilitating calcification, and their biogenesis may be linked to autophagy disruption. Howev...