Aintree University Hospitals NHS Foundation Trust

The Impact of Diabetes on Risk of Revision Following Anterior Cruciate Ligament Reconstruction: A Real-World Data Study

Given the increasing prevalence of diabetes mellitus (DM), understanding its impact on anterior cruciate ligament reconstruction (ACLR) revision risk is important for clinical decision-making and patient counselling. This study evaluated whether DM is associated with an increased...

Essex-Lopresti Injuries: A Systematic Review

Abstract Essex-Lopresti injuries (ELIs) are rare, and complex forearm injuries involving radial head fracture, interosseous membrane (IOM) rupture, and distal radioulnar joint (DRUJ) instability. We performed a systematic review to define diagnostic criteria, explore treatment st...

Increased risk of steatotic liver disease, major adverse liver outcomes, cardiovascular events and mortality in pheochromocytoma: a model of chronically elevated sympathetic tone

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally, yet the contribution of autonomic dysfunction to its progression remains incompletely understood. Pheochromocytoma and paraganglioma (PPGL), characteris...

Hindfoot Instability Test—Introduction and Validation of an Intraoperative Diagnostic Test of Hindfoot Instability in Deltoid Ligament Injury Associated With Ankle Fractures

The deltoid ligament complex (DLC) is well-known as an ankle joint stabilizer; however, through the superficial DLC, it also acts at the subtalar joint and helps to maintain the medial longitudinal arch. DLC repair in the presence of an ankle fracture remains a topic of controver...

The impact of social protection interventions on treatment and socioeconomic outcomes of tuberculosis-affected people and households in low income, high burden settings: A systematic review and meta-analysis

Abstract Introduction Tuberculosis (TB) is the leading cause of death due to infectious disease worldwide. Social protection interventions can benefit TB-affected households. We conducted a systematic review and meta-analysis to quantify the effectiveness of social protection on...

Healing Following Endoscopic Reconstruction of the Anterior Skull Base in Patients With Sinonasal Malignancies

ABSTRACT Background Healing dynamics after anterior skull base (ASB) reconstruction following transnasal endoscopic surgery (TES) for sinonasal malignancies remain poorly characterized. This study aimed to describe the postoperative healing process, quantify time to healing, iden...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...