Ain Shams University

Impact of patient positioning on the efficacy and safety of doxycycline pleurodesis in malignant pleural effusion: a pilot randomized trial

Abstract Background Chemical pleurodesis is a standard palliative intervention for recurrent malignant pleural effusion (MPE). Historically, patient rotation after sclerosant instillation was routine to ensure uniform drug distribution, but evidence supporting this practice remai...

Histological evaluation of pulpal healing following direct pulp capping with polytetrafluoroethylene or melatonin, with or without adjunctive low-level laser therapy in Wistar rat molars

Abstract This study evaluated pulpal healing following direct pulp capping with polytetrafluoroethylene (PTFE) or melatonin (MEL), with or without adjunctive low-level laser therapy (LLLT), in Wistar rat molars. Fifty-two maxillary first molars from 26 male Wistar rats were inclu...

Feature engineering for intermittent demand forecasting: zero-detection and forecast performance across GRU, LSTM, and TCN architectures

Abstract Accurate forecasting of intermittent demand remains a persistent challenge for deep learning methods, partly due to the inadequacy of conventional error metrics in capturing zero-demand forecasting performance. This study tackles this gap by introducing Z% and NZ%, two d...

The Role of Artificial Intelligence Models in Predicting Post-Prosthetic Facial Esthetics in Edentulous Patients: Clinical and Anthropometric Comparative Study

Abstract Artificial intelligence (AI) is increasingly used in esthetic dentistry; however, its accuracy in predicting post-prosthetic facial outcomes in edentulous patients remains unclear. This study aimed to evaluate the ability of AI models to simulate post-denture facial esth...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

Clinical integration of trabecular bone score in precision osteoporosis care: a position statement by the Egyptian academy of bone and muscle health

Abstract Background Dual-energy X-ray absorptiometry (DXA)-derived bone mineral density (BMD) has long been the gold standard for osteoporosis diagnosis, yet its inability to account for bone quality leads to a significant “sensitivity gap” in fracture risk prediction. This posit...

Shear capacity of tapered web panel of plate girders with web opening

Abstract Tapered plate girders with web openings are widely used to route services and reduce weight, yet current provisions only partly capture the combined effects of tapering angle, opening size, panel aspect ratio, and web slenderness. A total of 115 shell finite-element (FE)...

Earthquake magnitude estimation using an optimized CNN-DNN-GRU model with binary differential evolution and firefly algorithm

Accurate earthquake magnitude estimation is critical for mitigating seismic hazards; however, the inherently nonlinear and dynamic characteristics of geophysical data present persistent modeling challenges. To address this complexity, this study proposes a novel hybrid deep learn...

Hidden hypertension and early cardiac alterations: insights from ambulatory blood pressure monitoring in children and adolescents

Abstract Background Hypertension is increasingly recognized as a significant health concern among children and adolescents, often associated with obesity and lifestyle choices. Early-onset hypertension can elevate the risk of cardiovascular diseases in adulthood, making early det...

Multi-analytical characterization and radiation shielding assessment of natural ophiolitic rocks: a combined experimental, mineralogical, and simulation analysis

Abstract Ophiolitic suites derived from oceanic crust are rich in ferromagnesian and mafic minerals and exhibit relatively high densities, making them promising and economical materials for radiation shielding. This study evaluates ophiolitic rocks exposed along the Marsa Alam–Id...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Cold and hot tumors: immunological determinants, cancer-immunity cycle dysregulation, and nanotechnology-driven therapeutic approaches

Abstract Cancer remains a major global health burden and the second leading cause of mortality worldwide. Recent advances in cancer immunotherapy have emphasized the critical role of the tumor microenvironment (TME) in determining therapeutic outcomes, leading to the classificati...

Fine Tuning of Ag3PO4/g-C3N4 Hybrid Nanostructure Catalyst for Natural Sunlight-Assisted Cationic Dye Neutralization

Photocatalysis is a promising route for the environmentally friendly destruction of organic pollutants and recycling the polluted water in industrial contexts for future environmental challenges. In this novel research work, the coupling of definite proportions of silver phosphat...

Nonlinear 2DOF van der Pol vibrations: El-Dib’s optimized frequency formula via the two-time-domains method

This paper presents a systematic decoupling framework for strongly coupled two-degree-of-freedom (2-DOF) nonlinear vibration systems. Here, the coupling is classified as strong rather than weak because the cross-mode interaction terms in the governing equations (e.g., the x 2 y-,...

plsMD: a plasmid reconstruction tool from short-read assemblies

Abstract Background While whole genome sequencing has become a cornerstone of antimicrobial resistance surveillance, the reconstruction of plasmid sequences from short-read data remains a challenge due to repetitive sequences and assembly fragmentation. Current computational tool...

Effect of an educational program on mothers' reported practice regarding care of their children with vitamin deficiencies

Abstract Background Vitamin deficiencies remain significant public health concerns that adversely affect children’s growth and development. Mothers, as primary caregivers, play a key role in shaping their children’s health practices. Therefore, this study aimed to evaluate the ef...

Rational design, synthesis, and antimicrobial evaluation of novel 1,2,3-triazole hybrids: structure–activity relationships, molecular docking, and DFT studies

A series of novel 2,4-dichlorophenyl-1,2,3-triazole derivatives and their structural hybrids incorporating chalcone, hydrazone, thio/semicarbazide, carbamate, and pyrazole moieties were rationally designed, synthesized, and characterized. The antimicrobial activity of the synthes...

Effect of seed treatment with UV radiation on Marjoram (Origanum majorana L.) active ingredients under saline conditions (Origanum majorana L or Majorana hortensis Moench.)

Abstract In a pot experiment, the dry seeds of the Sweet Marjoram plant ( Origanum majorana L.) were exposed to ultraviolet UV-C (254 nm) light for 30 and 60 min. They were subjected to salinity conditions (4 and 6 dS/m). Plants were evaluated, determining total chlorophyll (SPAD...

Improvement of Rock Grouts Using Eco-Friendly Lightweight Geopolymer Mortar Modified with Castor Oil-Based Rigid Polyurethane Foam

Conventional cement-based grouts used to stabilize fractured rock slopes and fill large cavities are heavy, carbon-intensive, and can impose excessive dead load on weakened rock masses. This study addresses these limitations by integrating bio-based rigid polyurethane—particularl...

Detoxification of aflatoxin M1 by eight lactic acid bacteria strains, alone or in combination, as viable and heat-killed cells in PBS, MRS broth, and Karish cheese

Abstract Aflatoxin M1 (AFM1) in milk is a major public health concern. It is a hydroxylated metabolite of aflatoxin B1 (AFB1), formed in the liver of animals after ingestion of contaminated feed and subsequently excreted into milk. Biological techniques could be used to combat th...