Ain Shams University

Multi-analytical characterization and radiation shielding assessment of natural ophiolitic rocks: a combined experimental, mineralogical, and simulation analysis

Abstract Ophiolitic suites derived from oceanic crust are rich in ferromagnesian and mafic minerals and exhibit relatively high densities, making them promising and economical materials for radiation shielding. This study evaluates ophiolitic rocks exposed along the Marsa Alam–Id...

Hidden hypertension and early cardiac alterations: insights from ambulatory blood pressure monitoring in children and adolescents

Abstract Background Hypertension is increasingly recognized as a significant health concern among children and adolescents, often associated with obesity and lifestyle choices. Early-onset hypertension can elevate the risk of cardiovascular diseases in adulthood, making early det...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Cold and hot tumors: immunological determinants, cancer-immunity cycle dysregulation, and nanotechnology-driven therapeutic approaches

Abstract Cancer remains a major global health burden and the second leading cause of mortality worldwide. Recent advances in cancer immunotherapy have emphasized the critical role of the tumor microenvironment (TME) in determining therapeutic outcomes, leading to the classificati...

Fine Tuning of Ag3PO4/g-C3N4 Hybrid Nanostructure Catalyst for Natural Sunlight-Assisted Cationic Dye Neutralization

Photocatalysis is a promising route for the environmentally friendly destruction of organic pollutants and recycling the polluted water in industrial contexts for future environmental challenges. In this novel research work, the coupling of definite proportions of silver phosphat...

Nonlinear 2DOF van der Pol vibrations: El-Dib’s optimized frequency formula via the two-time-domains method

This paper presents a systematic decoupling framework for strongly coupled two-degree-of-freedom (2-DOF) nonlinear vibration systems. Here, the coupling is classified as strong rather than weak because the cross-mode interaction terms in the governing equations (e.g., the x 2 y-,...

plsMD: a plasmid reconstruction tool from short-read assemblies

Abstract Background While whole genome sequencing has become a cornerstone of antimicrobial resistance surveillance, the reconstruction of plasmid sequences from short-read data remains a challenge due to repetitive sequences and assembly fragmentation. Current computational tool...

Effect of seed treatment with UV radiation on Marjoram (Origanum majorana L.) active ingredients under saline conditions (Origanum majorana L or Majorana hortensis Moench.)

Abstract In a pot experiment, the dry seeds of the Sweet Marjoram plant ( Origanum majorana L.) were exposed to ultraviolet UV-C (254 nm) light for 30 and 60 min. They were subjected to salinity conditions (4 and 6 dS/m). Plants were evaluated, determining total chlorophyll (SPAD...

Effect of an educational program on mothers' reported practice regarding care of their children with vitamin deficiencies

Abstract Background Vitamin deficiencies remain significant public health concerns that adversely affect children’s growth and development. Mothers, as primary caregivers, play a key role in shaping their children’s health practices. Therefore, this study aimed to evaluate the ef...

Rational design, synthesis, and antimicrobial evaluation of novel 1,2,3-triazole hybrids: structure–activity relationships, molecular docking, and DFT studies

A series of novel 2,4-dichlorophenyl-1,2,3-triazole derivatives and their structural hybrids incorporating chalcone, hydrazone, thio/semicarbazide, carbamate, and pyrazole moieties were rationally designed, synthesized, and characterized. The antimicrobial activity of the synthes...

Detoxification of aflatoxin M1 by eight lactic acid bacteria strains, alone or in combination, as viable and heat-killed cells in PBS, MRS broth, and Karish cheese

Abstract Aflatoxin M1 (AFM1) in milk is a major public health concern. It is a hydroxylated metabolite of aflatoxin B1 (AFB1), formed in the liver of animals after ingestion of contaminated feed and subsequently excreted into milk. Biological techniques could be used to combat th...

Improvement of Rock Grouts Using Eco-Friendly Lightweight Geopolymer Mortar Modified with Castor Oil-Based Rigid Polyurethane Foam

Conventional cement-based grouts used to stabilize fractured rock slopes and fill large cavities are heavy, carbon-intensive, and can impose excessive dead load on weakened rock masses. This study addresses these limitations by integrating bio-based rigid polyurethane—particularl...

Microbial and Enzymatic Transformation of Per- and Polyfluoroalkyl Substances (PFAS): From Defluorination and Biological Partitioning to a Separation-First Biological Treatment Framework

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants. Conventional destructive technologies, such as advanced oxidation and electrochemical processes, can achieve partial or complete defluorination. However, their high energy demand, chemical inputs,...

Enhancing biodegradation of polycyclic aromatic hydrocarbons using bacterial consortia and biofilm

Abstract The release of petroleum and its constituents, such as polycyclic aromatic hydrocarbons (PAHs), into the environment poses a significant global threat due to their toxic, genotoxic, mutagenic, and/or carcinogenic properties. Using indigenous PAH-degrading bacteria to dec...

Synthesis and molecular docking of novel pyrazole, pyrimidine, and pyridine derivatives as potent antimicrobial, antibiofilm, and anticancer agents

Abstract The development of novel antimicrobial and anticancer agents remains a priority due to rising drug resistance and high systemic toxicity of current treatments. A series of novel pyrazole ( 2–6 ), pyrimidine ( 7–10 ), and pyridine/oxazinone ( 11–14 ) derivatives were synt...

Retention and wear assessment of novel PolyEtherKetoneKetone versus traditional cobalt chromium material used in digital double crown retained removable partial dentures

BACKGROUND: Conventional removable partial dentures (RPDs) involve a process that is often susceptible to errors and demands a significant investment of time. The introduction of computer-aided design and computer-aided manufacturing (CAD/CAM) technology and materials witnessed s...

Translation of Dialect in Literature: A Case Study of The Adventures of Huckleberry Finn

This qualitative research employs a comparative textual analysis to examine the challenges of translating dialect-rich literature, focusing on the Arabic translations of Mark Twain's The Adventures of Huckleberry Finn by Maher Naseem and Nasr Abdelrahman published in 1998 and 200...

Evaluating the Role of MIA3 Variant rs17465637 in Coronary Artery Disease: A Comprehensive Case–Control Analysis

Objectives: Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide, yet population-specific evidence regarding the contribution of MIA3 genetic variation in Middle Eastern populations remains limited. This study investigated the association of...

Ventricular Tachycardia Ablation in Nonischemic Cardiomyopathy: Is Pulsed Field Ablation the Next Paradigm Shift?

Ventricular tachycardia ablation in nonischemic cardiomyopathy remains limited by high recurrence rates despite advances in catheter-based techniques. In nonischemic cardiomyopathy, the arrhythmogenic substrate is often heterogeneous and may involve intramural or epicardial myoca...

Can Carica papaya Serve as an Adjunct to Semaglutide in Mitigating Diabetes-Induced Testicular Injury Through Modulation of Oxidative Stress, Inflammation, Apoptosis, and the miR-34c/miR-155–SIRT1/FOXO1 Axis? An Experimental and Chem-Bio-Informatics Study

Diabetes mellitus (DM) induces significant endocrine disruption and oxidative stress (OS) within the testes, resulting in impaired spermatogenesis, increased sperm abnormalities, and compromised reproductive function. This study aimed to evaluate the combined protective effects o...