Affiliated Hospital of Qingdao University

Features and a specific pattern of cerebral perfusion in patients with Lewy body dementia: Diagnostic ability and clinical correlations

Cerebral perfusion changes have been observed in patients with both dementia with Lewy bodies and Parkinson’s disease dementia. In this study, features of cerebral blood flow (CBF) and a specific perfusion pattern measured using arterial spin labeling (ASL) MRI for Lewy body deme...

Predictive value of the superior endplate-cage angle for postoperative cage subsidence in stand-alone oblique lateral interbody fusion: a single-center retrospective study

Stand-alone oblique lateral interbody fusion (stand-alone OLIF) is a minimally invasive surgery for lumbar degenerative diseases, with cage subsidence as a common postoperative complication. This study aimed to investigate factors associated with cage subsidence following stand-a...

An intelligent OCR-LLM prescription review system for inpatient narcotic and psychotropic drugs

This study aimed to construct an intelligent prescription review system for inpatient narcotic and psychotropic drugs based on deep learning-based optical character recognition (OCR) and a local large language model (LLM) and evaluate its review performance and closed-loop manage...

Metabolomic-microbiomic integrated analysis reveals the role of intermittent energy restriction in Parkinson’s disease

AIMS: This study aimed to explore the neuroprotective effect of intermittent energy restriction (IER) on Parkinson's disease (PD) mice via multiomics. METHODS: All mice were randomly divided into four groups: the control group, the PD model group, the PD+IER group and the PD+L-Do...

Comparative Efficacy of Bone Defect Filler Strategies Following Lesion Debridement for Osteonecrosis of the Femoral Head: A Systematic Review and Network Meta‐Analysis

ABSTRACT Objective This study aimed to systematically review and compare the clinical and radiographic outcomes of different bone defect filler materials following lesion debridement for osteonecrosis of the femoral head (ONFH). Existing evidence on filler materials relies heavil...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Effects of Adjunctive Electroacupuncture on Chemotherapy-Induced Nausea and Vomiting and Quality of Life in Subjects With Gynecologic Malignancies: A Retrospective Cohort Study

Objective To evaluate the association of adjunctive electroacupuncture (EA) with chemotherapy-induced nausea and vomiting (CINV) and quality of life in subjects with gynecologic malignancies. Methods Clinical data were retrospectively collected from 168 subjects with gynecologic...

UHPLC‐MS/MS‐Based Quantification of 14 Renshen Guben Oral Liquid–Related Constituents in Cancer Patients With Neutropenia

OBJECTIVES: This study aimed to develop and validate a UHPLC-MS/MS method for the simultaneous determination of 14 constituents related to Renshen Guben Oral Liquid (RSGB) in human plasma and to explore concentration-absolute neutrophil count (ANC) associations in cancer patients...

Association between triglyceride-glucose-related indices and reproductive lifespan: a cross-sectional study from the NHANES (2007–2020)

Objective The female reproductive lifespan, characterized by the period spanning from menarche to menopause, may be modulated by metabolic health factors. This cross-sectional analysis utilized nationally representative survey data from the National Health and Nutrition Examinati...

Association between USP6NL polymorphisms and Parkinson’s disease in Northern Chinese Han population: a case-control study

The pathogenesis and progression of Parkinson’s disease (PD) are closely associated with impaired membrane trafficking. As a key regulator of membrane trafficking, this study examined the association between two USP6NL polymorphisms (rs61844597 and rs73569171) and PD risk in the...

Defect-engineered high-entropy spinel ferrite nanofibers via Joule heating for superior microwave absorption

Abstract Spinel ferrites with exceptional magnetic permeability, optimal impedance matching, and robust chemical stability have attracted considerable attention in high-performance electromagnetic wave (EMW) absorption applications, yet their insufficient dielectric dissipation a...

Association of rituximab with survival outcomes in primary testicular diffuse large B-cell lymphoma: a systematic review and meta-analysis of retrospective studies

Abstract Background Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is the most common subtype of primary testicular lymphoma (PTL). Standard treatment protocols generally encompass a multimodal approach, incorporating radical orchiectomy, rituximab-based chemotherapy...

Research Advances in Spontaneous Coronary Artery Dissection

Spontaneous coronary artery dissection (SCAD) is a condition characterized by myocardial injury resulting from the rupture of the coronary artery intima or the formation of an intramural hematoma and is unrelated to atherosclerosis. Recent studies have reported that SCAD accounts...

Exploratory association of a composite preoperative myxoma-related clinical burden index with recovery duration after cardiac myxoma resection: a retrospective cohort study

Cardiac myxoma is a benign primary cardiac tumor, but its clinical impact varies with tumor size, mobility, valvular obstruction, pulmonary arterial pressure, and preoperative functional status. Whether an integrated myxoma-related preoperative clinical burden is associated with...

Ex Situ Luring Sterilization and Visual Tracking for Wound Healing Acceleration

Abstract Conventional sterilization methods, such as advanced oxidation and cationic antimicrobial action, inevitably cause harm to host tissues because of their in situ attack mode. The residual bacterial debris further increases the risk of secondary infection. Additionally, th...

Expression level of lncRNA MIR210HG in high-grade serous ovarian cancer tissues and its correlation with clinicopathological features and prognosis

Abstract Objective To investigate long non-coding RNA (lncRNA) MIR210HG expression in high-grade serous ovarian cancer (HGSOC) and its correlation with clinicopathological features, clinical outcomes, and prognosis. Methods Tissue samples were collected from 84 patients with HGSO...

Diagnostic performance of ultrasound-derived fat fraction for detecting hepatic steatosis in patients with tumor-related liver disease

Accurate assessment of hepatic steatosis is crucial for preoperative risk stratification in patients with liver tumors. However, the diagnostic performance of the noninvasive ultrasound-derived fat fraction (UDFF) remains uncertain, where tissue heterogeneity can impair measureme...

Neurocognitive Changes and Cerebral Blood Flow in Patients with Symptomatic Carotid Artery Stenosis before and after Carotid Endarterectomy

Objective : Carotid endarterectomy (CEA) reduces stroke risk in carotid stenosis patients, with potential but unclear benefits on cognitive function and cerebral blood flow (CBF). This study aimed to assess cognitive and CBF changes after CEA in patients with transient ischemic a...

A machine learning model for predicting early adverse outcomes after surgery in patients with early-onset rectal cancer: a two-center retrospective cohort study

Patients often present at advanced stages of early-onset rectal cancer (EORC), which is becoming more common. Within a year following rectal resection, some patients experience early adverse outcomes (EAO), such as severe complications, recurrence, or death; however, there is cur...

Single-cell and spatial transcriptomics reveal glycolytic remodeling and ENO1-associated metabolic vulnerability in hepatoblastoma

Hepatoblastoma (HB) is the most common malignant liver tumor in children; however, the contribution of glycolytic metabolic reprogramming to HB development and progression remains incompletely characterized. We integrated single-cell RNA sequencing and spatial transcriptomic data...