Affiliated Hospital of Qingdao University

Unilateral Functionalization of Covalent Organic Frameworks: Local Electronic Modulation and Morphology-Enabled Mass Transport for Electrocatalytic Hydrogen Peroxide Production

Abstract Achieving high selectivity and activity in the two-electron oxygen reduction reaction (2e– ORR) pathway critically depends on the synergistic modulation of a catalyst’s electronic structure and mass diffusion channels. This work proposes an asymmetric modulation strategy...

Stable truncating mutations in plakophilin-2 induce arrhythmogenic cardiomyopathy-like phenotypes in adult zebrafish

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder characterized by arrhythmias and fibrofatty myocardial remodeling, often leading to heart failure and sudden cardiac death. Mutations in plakophilin-2 ( PKP2 ) represent the most prevalent genetic cause of ACM....

Preoperative imaging predictors of intraoperative conversion and associated procedural and early postoperative outcomes during single-level L4–5 oblique lumbar interbody fusion: a retrospective cohort study

This study investigated plan–execution mismatch in single-level L4–5 oblique lumbar interbody fusion (OLIF) by evaluating whether a planned anterior-to-psoas approach could be maintained, identifying imaging factors associated with intraoperative conversion, and characterizing in...

Establishing CT-number-to-electron/density curves for hypersight CBCT with a standard cirs 062 M phantom: a methodological comparison of three practical approaches

HyperSight cone-beam computed tomography (CBCT) with Acuros reconstruction is reported to enable direct dose calculation in adaptive radiotherapy, but its accuracy depends on a reliable CT-number-to-electron/material-density (CT-ED/MD) calibration curve.The CT-number-to-material-...

Prediction of prognosis and treatment effect of cervical cancer by immunogenic cell death-related genes

Background Immunogenic cell death (ICD) is a potential mechanism that mediates adaptive immune responses during anticancer therapy. However, expression patterns and clinical implications of ICD related genes in cervical squamous cell carcinoma and endocervical adenocarcinoma (CES...

Associations of cumulative exposure and change pattern of the C-reactive protein-triglyceride-glucose index with stroke risk in a population with cardiovascular-kidney-metabolic syndrome stages 0–3: a longitudinal analysis based on CHARLS

The C-reactive protein–triglyceride-glucose index (CTI) has shown potential in cardiometabolic risk assessment. However, evidence regarding cumulative CTI (cuCTI) exposure, longitudinal CTI change pattern, and incident stroke in individuals with cardiovascular-kidney-metabolic (C...

Copper-based targeted nanozyme platform with sequential phototherapy-enzymatic therapy for orchestrating macrophage homeostasis in rheumatoid arthritis

Rheumatoid arthritis (RA) remains a formidable clinical challenge due to the vicious cycle of hyperactivated M1 macrophages, excessive reactive oxygen species (ROS), and sustained pro-inflammatory cytokine storm. Herein, we rationally engineered a targeted copper-based nanozyme p...

From baseline levels to cumulative exposure and longitudinal trajectories: estimated glucose disposal rate and incident cardiometabolic multimorbidity among middle-aged and older adults in the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS)

Abstract Background Insulin resistance is implicated in the development of cardiometabolic multimorbidity (CMM), but evidence regarding the associations of baseline, cumulative, and longitudinal patterns of estimated glucose disposal rate (eGDR) with incident CMM remains limited....

Targeting the CD4+ effector memory T cells re-expressing CD45RA suppressor galectin-7: a multi-omics-guided therapeutic strategy for idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease with limited therapeutic options. Although single-cell and spatial transcriptomics have revealed cellular heterogeneity within the IPF lung microenvironment, the immune drivers with causal rel...

A hybrid CNN-transformer network with global-local context feature aggregation for lung medical image segmentation

Accurate lung segmentation is a key prerequisite for computer-aided diagnosis of pulmonary diseases on chest CT and X-ray images. Lung segmentation, however, remains highly challenging due to the complex anatomy of the lung, ambiguous lesion boundaries, low tissue contrast, and t...

PRP‐Integrated Conductive Hydrogels With Dynamic Crosslinking for Accelerated Wound Healing and Physiological Monitoring

ABSTRACT The capability to simultaneously promote wound healing and enable real‐time monitoring is critical for effective wound management, especially in dynamic and infection‐prone regions such as joints, yet unmet needs remain in clinical practice. Herein, we present a multifun...

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

ABSTRACT Intervertebral disc degeneration (IVDD) is a major cause of low back pain and is closely associated with metabolic imbalance within the disc microenvironment, yet the underlying mechanisms remain poorly understood. Here, we identify ammonia accumulation as a metabolicall...

APOF regulates the malignancy and inflammatory response of hepatocellular carcinoma cells through PPAR signaling pathway

Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence. It is often diagnosed at an advanced stage, with intrahepatic or extrahepatic metastasis, and cannot be cured by radical surgery. In human HCC cell lines, Apolipoprotein F (APOF) gene promoter activity was s...

Low miR-106a-5p is associated with burn-related DVT and may regulate endothelial injury via TXNIP

Among burn patients, deep vein thrombosis (DVT) frequently arises as a critical complication. This article aims to explore the mechanism of miR-106a-5p in DVT in burn patients, providing a basis for identifying early diagnostic markers and developing therapeutic targets. This stu...

FGF21 Pretreatment Promotes the Cardioprotective Effects of Mesenchymal Stem Cells in Myocardial Infarction via Enhancement of Their Survival and Paracrine Effects

Background: The poor engraftment of mesenchymal stem cells (MSCs) in the ischemic heart post transplantation heavily restricts their cardioprotective benefits in myocardial infarction (MI). Pretreatment has emerged as a novel approach to enhance the biological properties of MSCs...

ATG7 rs1375206 Genotype as a susceptibility biomarker for preeclampsia in the Chinese Han population

Preeclampsia (PE) is linked to placental dysplasia and autophagy disorder. Atg7 is vital for placental development, yet its rs1375206 polymorphism with PE risk in Chinese Han population remains unclear. This study enrolled 990 PE patients and 1004 controls to genotype Atg7 rs1375...

A perinatal nomogram enables two-step screening for umbilical cord blood donors from antenatal assessment to bedside confirmation

Abstract The high-quality umbilical cord blood (HQUCB) is closely related to successful cord blood transplantation, and given the substantial resources required for umbilical cord blood (UCB) collection, processing, and storage, optimizing the identification of HQUCB donors for c...

A multi-modal mixture-of-experts deep network with cross-pathway attention fusion and hierarchical Tree-SHAP attribution for interpretable heterogeneous prediction

Heterogeneous multi-modal data that mixes categorical demographics, continuous biomarkers and high-dimensional binary indicators remains a long-standing challenge for deep learning, particularly when fusion across modalities is delegated to undifferentiated attention blocks and w...

HCTNet: a hierarchical hybrid convolution-transformer network with bidirectional cross-attention fusion for brain tumor MRI classification

Accurate brain tumor classification from magnetic resonance imaging (MRI) requires modelling both fine-grained local cues, such as tumor margins and intensity heterogeneity, and long-range contextual cues, such as the spatial relationship between the lesion and the surrounding an...

Eupatilin Alleviates Acute Myocardial Ischemia‐Reperfusion Injury in Rats via the Akt/GSK‐3β Pathway by Targeting COXs

ABSTRACT Eupatilin confers cardioprotection against myocardial ischemia‐reperfusion injury (MIRI). Cyclooxygenases (COXs) serve as key rate‐limiting enzymes for prostaglandin biosynthesis. This study investigated the effects of eupatilin on COXs. H9c2 cells subjected to oxygen‐gl...