Affiliated Hospital of Qingdao University

Expression level of lncRNA MIR210HG in high-grade serous ovarian cancer tissues and its correlation with clinicopathological features and prognosis

Abstract Objective To investigate long non-coding RNA (lncRNA) MIR210HG expression in high-grade serous ovarian cancer (HGSOC) and its correlation with clinicopathological features, clinical outcomes, and prognosis. Methods Tissue samples were collected from 84 patients with HGSO...

Diagnostic performance of ultrasound-derived fat fraction for detecting hepatic steatosis in patients with tumor-related liver disease

Accurate assessment of hepatic steatosis is crucial for preoperative risk stratification in patients with liver tumors. However, the diagnostic performance of the noninvasive ultrasound-derived fat fraction (UDFF) remains uncertain, where tissue heterogeneity can impair measureme...

Neurocognitive Changes and Cerebral Blood Flow in Patients with Symptomatic Carotid Artery Stenosis before and after Carotid Endarterectomy

Objective : Carotid endarterectomy (CEA) reduces stroke risk in carotid stenosis patients, with potential but unclear benefits on cognitive function and cerebral blood flow (CBF). This study aimed to assess cognitive and CBF changes after CEA in patients with transient ischemic a...

A machine learning model for predicting early adverse outcomes after surgery in patients with early-onset rectal cancer: a two-center retrospective cohort study

Patients often present at advanced stages of early-onset rectal cancer (EORC), which is becoming more common. Within a year following rectal resection, some patients experience early adverse outcomes (EAO), such as severe complications, recurrence, or death; however, there is cur...

Single-cell and spatial transcriptomics reveal glycolytic remodeling and ENO1-associated metabolic vulnerability in hepatoblastoma

Hepatoblastoma (HB) is the most common malignant liver tumor in children; however, the contribution of glycolytic metabolic reprogramming to HB development and progression remains incompletely characterized. We integrated single-cell RNA sequencing and spatial transcriptomic data...

Targeting the Thy-1 mechanotransduction regulator rescues regenerative wound healing and induces hair follicle neogenesis under high tension

Abstract Mechanical tension is a critical driver of hypertrophic scar (HS) formation, primarily by inducing the differentiation of fibroblasts into pathological myofibroblasts. However, the upstream mechanotransduction regulators that initiate this fibrotic cell fate switch remai...

Comparison of transumbilical single-port and conventional multi-port laparoscopic hepatectomy for benign liver lesions

Transumbilical single-port laparoscopic hepatectomy represents a further refinement of minimally invasive liver surgery, but its safety and perioperative value remain insufficiently defined. This study aimed to compare transumbilical single-port laparoscopic hepatectomy with conv...

Study on the pathogenic mechanisms and clinical treatment of advanced glycation end products (AGEs) in diabetic complications

The accumulation of Advanced Glycation End Products (AGEs), resulting from the Maillard Reaction formed via exogenous intake from food and a hyperglycemic internal environment in the body, can cause or exacerbate various complications of Diabetes Mellitus. This article discusses...

Acridine-Based[68Ga]Ga- and [18F]AlF-Labeled PSMA RadiotracersEnabling High-Contrast PET Imagingwith Minimized Undesired Retention

Abstract Prostate-specific membrane antigen (PSMA)-targeted radioligands have achieved clinical success in prostate cancer imaging, yet nonspecific uptake in normal tissues remains a challenge. Here, we developed a series of acridine-based PSMA ligands and systematically investig...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Microfluidic engineering of CeO2/Peptide nanosheet-integrated bioactive hydrogel microspheres for multi-enzymatic biomimetic catalytic therapy of osteoarthritis

Osteoarthritis (OA) is a degenerative joint disease characterized by chronic inflammation and oxidative stress-induced cartilage degeneration, yet effective disease-modifying therapies remain limited. Herein, we report a CeO 2 /peptide nanosheet (CeP)-integrated hydrogel microsph...

Estimating individualized gonadotropin starting doses in women with PCOS: a target-driven machine learning model for GnRH-antagonist stimulation

Abstract Background Women with polycystic ovary syndrome (PCOS) are prone to excessive ovarian response and ovarian hyperstimulation syndrome (OHSS) during controlled ovarian stimulation, whereas overly conservative gonadotropin (Gn) dosing reduces oocyte yield and efficiency. Th...

Neural regulation in lung cancer: from mechanisms to new therapeutic perspectives

Lung cancer remains a leading cause of cancer-related deaths worldwide. Despite advances in targeted therapy and immunotherapy, treatment outcomes are often constrained by tumor heterogeneity and the complex tumor microenvironment. Recent studies highlight the critical role of th...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...

Risk factors for incident chronic kidney disease following unilateral nephrectomy: a systematic review and meta-analysis

Nephrectomy is standard for kidney tumors and living kidney donation, but postoperative chronic kidney disease (CKD) is a critical determinant of long-term outcomes. Risk factors for incident CKD after unilateral nephrectomy remain incompletely synthesized. PubMed, Embase, Web of...

Post-injury high-sensitivity C-reactive protein to lymphocyte ratio and nonunion risk in adult extremity fractures: evidence from a multicenter retrospective cohort

Early immuno-inflammatory response serves a critical role in the process of fracture healing, and both excessive and insufficient activation after injury may predict adverse outcomes. This study aimed to investigate the association between post-injury high-sensitivity C-reactive...

A mitochondria-related 9-gene induced sputum signature for severe asthma: an integrative transcriptomic analysis with external validation

OBJECTIVE: Severe asthma is biologically heterogeneous, and airway-derived biomarkers for disease stratification remain limited. We aimed to identify a mitochondria-related induced sputum transcriptomic signature associated with severe asthma. METHODS: Two public induced sputum m...