Aarhus University Hospital

Comparison of the Distribution of Fitness Effects Across Primates

Abstract The distribution of fitness effects (DFE) of mutations is a key determinant of both the efficacy of natural selection and the genetic load of populations. It also provides an indirect summary of the underlying fitness landscape, so the extent to which the DFE is conserve...

Sex and Socioeconomic Differences in the Initiation of SGLT2 Inhibitors and GLP ‐1 Receptor Agonists in Patients With Type 2 Diabetes and Cardiovascular Disease: A Nationwide Cohort Study

ABSTRACT Aims Cardioprotective glucose‐lowering drugs (GLDs) remain underutilised in individuals with Type 2 diabetes (T2D) and cardiovascular disease (CVD). We aimed to estimate the association between sex and socioeconomic status and initiation of cardioprotective GLDs and to i...

Which penile cancer patients with metastasis in a sentinel node may be spared inguinal lymph node dissection without compromising oncological safety? Development of a low-risk selection model

Abstract Purpose To develop and internally validate a low-risk selection model to guide omission of completion inguinal lymph node dissection (ILND) after a positive dynamic sentinel node biopsy (DSNB) and to identify predictors of an inguinal basin harboring additional inguinal...

Quality in Palliative Care for Patients With Pre-existing Severe Mental Disorders – A Questionnaire Study With Danish Health Care Professionals

Background Patients with severe mental disorders (SMDs) face disparities in end-of-life care, yet knowledge about the quality of palliative care is limited. Aims This study examined healthcare professionals’ perspectives on palliative care for patients with SMDs. Methods Question...

How the nurse–patient relationship is enacted in Danish intensive care units: An ethnographic study of conscious mechanically ventilated patients

Introduction The nurse–patient relationship is crucial for conscious mechanically ventilated patients in the intensive care unit (ICU). While critical illness, immobilisation, and communication barriers challenge this relationship, the knowledge of its enactment in practice remai...

Electroconvulsive Therapy in Denmark From 2017 to 2025

OBJECTIVE: Electroconvulsive therapy (ECT) is a well-established treatment for severe manifestations of mental illness. This study examined trends in ECT use in Denmark from 2017 to 2025 using nationwide data from the Danish National Patient Register. METHODS: The data were analy...

Impaired Lung Function in Liver Transplant Recipients Compared With the General Population: A Nationwide Matched Cohort Study

Background. Liver transplant recipients have elevated risk of acute pulmonary infections, but the burden of chronic pulmonary diseases in liver transplant recipients remains largely unknown. We aimed to determine the association between living with a transplanted liver and both s...

Pattern of Failure in Nasopharyngeal Carcinoma After Radiotherapy in a Low‐Incidence Population: A DAHANCA Study

BACKGROUND: Nasopharyngeal carcinoma (NPC) is uncommon in many populations. Most existing clinical evidence comes from endemic areas, where Epstein-Barr virus (EBV)-associated subtypes predominate. We analyzed patterns of failure in a population-based cohort from Denmark, a low-i...

Disease-activity-linked complement-coagulation interactions and persistent platelet activation in treatment-naïve systemic lupus erythematosus

Background Thrombosis is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). Although multiple prothrombotic pathways have been identified, most have been studied individually or after treatment initiation. We aimed to characterize interactions between...

Fractional CO₂ vaginal laser therapy for genitourinary syndrome of menopause in breast cancer survivors: a scoping review

Genitourinary syndrome of menopause (GSM) is highly prevalent among breast cancer survivors (BCSs), largely due to treatment-induced hypoestrogenism. Hormonal therapies are often contraindicated, creating a need for non-hormonal options. This scoping review aimed to map and criti...

Phenotypic manifestations and variant reclassification of germline PTEN variants: a nationwide Danish study

Background Classification of heterozygous germline PTEN variants in patients with, or suspected of having, PTEN hamartoma tumour syndrome (PHTS) remains challenging. Accurate classification is essential as these patients require lifelong cancer surveillance. Methods We identified...

Associations between reduction of hypotension and treatment intensity in hypotension prediction index studies

BACKGROUND: The Hypotension Prediction Index (HPI) is developed for proactive prevention of hypotension and existing meta-analyses report reduced hypotension with HPI-guided management in comparison with a strategy based on MAP alerts of 65 mmHg. Still, validation studies suggest...

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers

Penile cancer is a severe disease, and a large proportion is related to high-risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population-based data on the prevalence of p16 in penile cancer is scarce. We investigat...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...

A Novel Tool to Create Digital Twin Temporal Bone Models for Virtual and 3D-Printing: Proof-of-Concept and Evaluation

Objective: To develop a haptic software tool for creating digital twin models for virtual or physical interaction based on cone beam (CB) computed tomography (CT) temporal bone imaging and to evaluate the quality of resulting 3D-printed models. Background: Temporal bone surgery i...

Collagen remodeling is elevated in fibrotic hypersensitivity pneumonitis and may distinguish it from idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (fHP) are two common causes of pulmonary fibrosis. Unlike IPF, fHP is caused by a persistent immune response to an antigen. Misclassification of fHP and IPF can lead to significant delays in antifibroti...

Laser interstitial thermal therapy in pediatric neurosurgery: a prospective nationwide study on indications, safety, and early outcomes

Abstract Purpose To evaluate indications, safety, and early outcomes of MRI-guided laser interstitial thermal therapy (LITT) in a nationwide prospective pediatric cohort and to assess the feasibility of same-session stereotactic biopsy. Methods All consecutive pediatric patients...

Characteristics of Monozygotic Twins Discordant for Anorexia Nervosa: Comprehensive Risk Evaluation for Anorexia Nervosa in Twins (CREAT) Study

ABSTRACT Objective To characterise the clinical and phenotypic profile of the Comprehensive Risk Evaluation for Anorexia nervosa in Twins (CREAT) cohort, identify candidate risk and illness‐related correlates of AN, and establish a foundation for forthcoming biological, neuroimag...

Post‐traumatic Psychopathology and Cardiovascular Risk: A Danish Case–Control Study of Sex‐Specific Associations

Background There is increasing recognition that trauma exposure and related psychiatric consequences predict cardiovascular disease risk. However, most research has specifically examined post‐traumatic stress disorder—despite evidence that a range of psychiatric disorders may fol...

Locking plate fixation compared with tension-band wiring for patellar fractures: a multicentre randomized controlled trial

Aims Patellar fractures are associated with considerable postoperative morbidity, and tension-band wiring has high complication rates and suboptimal outcomes. Locking plate fixation is a recent surgical innovation which confers superior biomechanical stability. However, there is...