Aarhus University Hospital

Development and Validation of a Blood Test Informed Risk Prediction Model for Lung Cancer—The Copenhagen Lung Cancer Risk Model (CPH-Lung)

Purpose Lung cancer screening reduces lung cancer mortality, but identifying high-risk individuals remains difficult. We wanted to develop a blood test–based risk model (CPH-Lung) to improve risk stratification before image-based screening. Materials and Methods We included indiv...

Hypoxia and right ventricular dysfunction in patients with acute pulmonary embolism

In patients with acute pulmonary embolism (PE), hypoxia may increase pulmonary vascular resistance and worsen right ventricular dysfunction (RVD), which is a key prognostic factor. However, associations between hypoxia, RVD and clinical outcomes have not been well described. To d...

Persistent Health Disparities Among Adult Cancer Survivors

ABSTRACT Cancer survivors face elevated risks of age‐ and treatment‐related health conditions, possibly due to accelerated biological aging from cancer therapy. The role of social determinants of health (SDOH) in these aging trajectories remains understudied. We conducted a retro...

Urine Ammonium During Normothermic Machine Perfusion as a Marker of Donor Kidney Function

Background. Optimizing graft selection remains a central priority, and normothermic machine perfusion (NMP) provides a potential platform for pretransplant organ assessment. Kidney ammonium excretion quantifies proximal tubular and interstitial function. This study investigated u...

Profiling peripheral immune cells in Parkinson's disease: A scoping review

Parkinson's disease (PD) is increasingly recognized as a multi-system disorder with immune dysregulation extending beyond the central nervous system. Although numerous studies have examined peripheral immune alterations in people with PD, findings remain heterogeneous and difficu...

Treatment of male osteoporosis: a narrative review and position statement by the ECTS Clinical Action Group.

Osteoporosis in men is under-recognized and under-treated despite a substantial disease burden and poorer fracture-related outcomes than in women. Secondary osteoporosis is highly prevalent in men, making the identification and management of underlying causes essential. Bone mine...

Autoantibodies neutralizing type I IFNs underlie ~5% of herpes simplex encephalitis in adults.

Inborn errors of type I interferon (IFN-I) immunity account for ∼7-8% of herpes simplex encephalitis (HSE) cases in young children, but the pathogenesis of HSE in adults is largely unknown. We report that IFN-I autoantibodies (auto-Abs) in serum/plasma samples drawn before, durin...

Early antimicrobial therapy and clinical outcomes of left-sided Enterococcus faecalis endocarditis: a NIDUS registry study

Abstract Purpose Antimicrobial therapy of Enterococcus faecalis endocarditis treatment is challenged by high intrinsic resistance and relapse rates. Knowledge on practice patterns is warranted. We aimed to describe early-phase monotherapy and combination therapy use in E. faecali...

Changes in skeletal muscle and physical function after cardiac surgery: a prospective study

Objectives To assess postoperative changes in muscle mass and quality, factors associated with these changes, and sarcopenia prevalence in older cardiac surgery patients. Design Secondary observational analysis of a randomized controlled early rehabilitation trial Setting Tertiar...

Entrepreneurial agency in mission oriented innovation policies

Policy makers have recently turned to mission-oriented innovation policies (MOIPs) to direct entrepreneurial activity towards societal goals. Yet, while entrepreneurial experimentation is a key component of missions, there has been limited exchange between the MOIP literature and...

Nurses' Perspectives on a Communication Model Between Providers and Mechanically Ventilated Patients in the Intensive Care Unit

ABSTRACT Background Communication with mechanically ventilated patients in intensive care is complex. Decades of research demonstrate that communication barriers are commonly experienced and one of the most challenging experiences during an intensive care stay. Support for the he...

Metformin Pharmacogenetics in Heart Failure Patients with Reduced Ejection Fraction: Impact on Metformin and Growth Differentiation Factor-15 Plasma Levels

This study assessed plasma metformin trough steady-state concentrations and plasma growth differentiation factor-15 (GDF-15) in patients with heart failure with reduced ejection fraction (HFrEF), and evaluated the effect of genetic variations in OCT1, OCT2, MATE1, and MATE2-K on...

Müllerian Duct Aplasia in a Girl With SMARCB1 ‐Related Coffin–Siris Syndrome: A Rare Co‐Occurring Anomaly

ABSTRACT Genetic etiologies of Müllerian aplasia (Mayer–Rokitansky–Küster–Hauser syndrome) remain poorly understood. Identification of patients with monogenic syndromes presenting with Müllerian aplasia may help improve our knowledge of the underlying biology. We investigated a 1...

Long-term Trends in Upper Gastrointestinal Bleeding and Ischemic Outcomes after Myocardial Infarction

Abstract Aims Invasive management and intensive antithrombotic regimens have decreased ischemic risk after myocardial infarction (MI) at the cost of more bleeding. Of particular concern is upper gastrointestinal bleeding (UGIB), which is both common and preventable, yet not well...

Using the Danish Administrative Registers to Define Mental Disorders: Potential and Limitations of Using Different Data Sources

BACKGROUND: Although the Danish health registers provide rich data for epidemiological mental health research, the comparability of findings is hindered by different definitions of mental disorders across studies. We aimed to describe different approaches taken by researchers to...

Potentially inappropriate prescribing in individuals with type 2 diabetes mellitus: a Danish nationwide study

Abstract Aim We aim to describe the prevalence of potentially inappropriate prescribing (PIP) in individuals with type 2 diabetes mellitus. Furthermore, we aim to explore associations between PIP and different individual-level factors. Subject and methods This was a nationwide re...

Operationalizing fear of cancer recurrence care: a modified Delphi study establishing a consensus-based clinical pathway for Danish cancer survivors

BACKGROUND AND PURPOSE: Fear of cancer recurrence (FCR) is a prevalent concern among cancer survivors. Although evidence-based FCR guidelines exist, their implementation requires further operationalization. This study aimed to establish expert consensus on a clinical pathway to o...

Sustained Ventricular Tachycardia as the First Presentation of Hereditary Transthyretin Amyloidosis With the Glu109Gln Mutation

Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) most commonly presents with heart failure symptoms. Sustained ventricular tachycardia (VT) is an uncommon initial manifestation. Case Summary: A 57-year-old man presented with hemodynamically unstable monomorphic VT requi...

Prognostic Value of Coronary Computed Tomography Angiography–Derived Fractional Flow Reserve From a Large Nationwide Cohort

BACKGROUND: The diagnostic value of coronary computed tomography angiography–derived fractional flow reserve (FFR-CT) in stable coronary artery disease is well established. The prognostic value of predicting future cardiovascular events is less clear, as studies are limited by sm...

The Global Carbon Budget as a cointegrated system

Abstract The Global Carbon Budget, maintained by the Global Carbon Project, summarizes Earth’s global carbon cycle through four annual time series beginning in 1959: atmospheric CO2 concentrations, anthropogenic CO2 emissions, and CO2 uptake by land and by ocean. We analyze these...