Aarhus University Hospital

Patient preferences for the multidisciplinary management of endometriosis and adenomyosis: a mixed-methods survey-based study

Background: Endometriosis and adenomyosis are common, debilitating conditions frequently associated with delayed diagnosis and fragmented care-based pathways. In Denmark, two highly specialized centres provide advanced endometriosis treatment. However, it remains unclear whether...

Impact of Charlson Comorbidity Index conditions on one-year survival in patients with breast cancer: a Danish population-based cohort study

Breast cancer is the most frequently diagnosed malignancy in women. The Charlson Comorbidity Index (CCI) is a widely used tool for quantifying multimorbidity. As the population ages, breast cancer incidence and comorbidity prevalence are expected to grow. We therefore investigate...

Circulating biomarkers reflecting type III, IV and VI collagen remodeling are present in lung tissue of patients with pulmonary fibrosis and non-fibrotic controls

Abstract Background The extracellular matrix (ECM) is a dynamic network that provides structural support and maintains tissue homeostasis. Collagens are the main structural components of the ECM, occupying distinct tissue compartments and serving specialized roles. Dysregulated E...

Prognostic Impact of Kidney Function before Transcatheter Aortic Valve Implantation - A Nationwide study

Abstract Background Prognosis after transcatheter aortic valve implantation (TAVI) keeps improving, yet some high-risk groups persist with chronic kidney disease being one. Contemporary data on the prognostic importance of pre-TAVI kidney function are sparse, leaving uncertainty...

Early life exposures association with later diagnosis of spondyloarthritis: A population-based case-control study

Objective To assess whether early-life antibiotics are associated with spondyloarthritis (SpA) diagnosed by age 21. Methods In this population-based, matched case–control study, we used Danish live births (1997-2023) restricted to those reaching minimum relevant ages by December...

Evaluating patient-controlled admissions in adolescent psychiatric care: a quantitative study

BACKGROUND: An agreement on Patient-Controlled Admissions (PCA) is enabling patients to initiate at brief inpatient stay, on their own initiative, outside the existing referral system, at a well-known ward. PCA has mostly been studied in adult psychiatry, and the purpose of the c...

Mechanical limits shape the eccentric form of rose prickles

Abstract Rose prickles are vegetal weapons familiar to most green-thumbed individuals. Their distinctive feature is an oval cross-section, which contrasts with the mostly circular shapes of natural and man-made stingers. However, the reason for their eccentricity remains poorly u...

Pathways to resilience: how women entrepreneurs build the resilience to become entrepreneurs

Purpose This study investigates how women technology entrepreneurs build the resilience to navigate and persist within hyper-masculinised business incubator environments. It focuses on how formative experiences contribute to the development of resilience, and how these psychologi...

Blood Pressure Targets During General Anaesthesia in High‐Risk Patients—A Randomised Clinical Feasibility Trial

BACKGROUND: There is limited high-quality evidence to guide haemodynamic and respiratory management during general anaesthesia. The goal of this trial was to test the feasibility of testing different ventilatory settings and blood pressure targets. Previous trials on blood pressu...

Transthoracic drainage of lung abscesses (TOLA): protocol for a national multicenter randomized open-label trial

Introduction Lung abscess (LA) is a rare but severe necrotizing pulmonary infection associated with substantial morbidity and mortality. Current management relies on prolonged systemic antibiotic therapy without systematic use of abscess drainage. However, small case series and r...

Changes in appetitive traits and binge-eating following lifestyle intervention in 7–14-year-olds: a 3-year follow-up

Lifestyle interventions tend to reduce disordered eating short-term in children, but little is known about long-term changes. This study aimed to investigate changes in appetitive traits and episodes of overeating and binge-eating up to three years after a 10-week multicomponent...

Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers

ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years. The...

Children's lived experiences of transitioning between hospital and home in paediatric oncology: A qualitative study

PURPOSE: Advances in paediatric oncology have improved survival rates, but intensive treatments and frequent hospitalisations disrupt family life. Hospital-to-home transitions are critical yet underexplored in the cancer trajectory. Existing models of discharge planning primarily...

Analytical validity of CD20 as a biomarker in breast cancer patients using tissue microarrays and whole slide sections

Background Clinical utility of biomarker-based treatment depends on both analytical and clinical validity. CD20+ B-lymphocytes often form nodular lymphoid structures within tumors, presenting potential analytical issues if using tissue microarrays (TMA). We compared CD20 expressi...

Utility of Prognostic Staging Systems in Transthyretin Amyloidosis Cardiomyopathy in the Era of Available Disease‐Modifying Treatment

Background Prognostic staging systems in transthyretin amyloid (ATTR) cardiomyopathy were developed before the introduction of disease‐modifying treatment. We therefore evaluated contemporary risk stratification according to different staging systems in patients with ATTR cardiom...

Associated prognostic impact of opioid use before Transcatheter aortic valve implantation – A Danish nationwide cohort study

Background Opioid use is frequently reported as a baseline characteristic in transcatheter aortic valve implantation (TAVI) cohorts, yet its prognostic implications have not been examined. Aim To examine the association between pre-procedural opioid use and post-TAVI outcomes. Me...

Serial cardiac ultrasound in acutely ill adults: a systematic review

Background Cardiopulmonary symptoms frequently prompt emergency department (ED) visits. Serial as-sessment of dynamic cardiac ultrasound parameters may support monitoring, but their asso-ciation with patient outcomes and role in guiding management is uncertain. This systematic re...

Quality‐of‐life and late effects after transabdominal cerclage: A nationwide matched cohort study

INTRODUCTION: A transabdominal cerclage is inserted to prevent recurrent midtrimester loss and spontaneous preterm birth. The transabdominal cerclage often remains as a permanent foreign body for years. Synthetic materials within the abdomen, cesarean birth, and prior adverse pre...

Modern Higher-OrderCycloadditions

Abstract Higher-order cycloadditions, defined as pericyclic reactions involving more than 6π-electrons, have emerged as powerful and mechanistically diverse reactions that allow for the construction of larger and more complex polycyclic ring systems beyond the classical Diels–Ald...

Risk of Bias Associated with Varying Sampling Strategies for External Comparator Cohorts for Single‐Arm Trials: Insights from Aggressive Lymphoma

Marketing authorizations for oncology drugs are often based on single-arm trials (SATs), and real-world data-based external comparator cohorts (ECCs) are increasingly explored to contextualize results. In retrospective studies, comparators may be identified by time of diagnosis b...