Peter Mikuláš

Life as a Self-Sustaining Non-Equilibrium State: From Molecular Fluctuations to the Organization of Living Matter

The origin of life is traditionally investigated through the emergence of biomolecules, metabolic pathways, replication, and compartmentalization. These approaches, however, leave open a more general question: what physical principle could be shared by primitive prebiotic systems...

Life as a Self-Sustaining Non-Equilibrium State: From Molecular Fluctuations to the Organization of Living Matter

The origin of life is traditionally investigated through the emergence of biomolecules, metabolic pathways, replication, and compartmentalization. These approaches, however, leave open a more general question: what physical principle could be shared by primitive prebiotic systems...

Life as a Self-Sustaining Non-Equilibrium State: From Molecular Fluctuations to the Organization of Living Matter

The origin of life is traditionally investigated through the emergence of biomolecules, metabolic pathways, replication, and compartmentalization. These approaches, however, leave open a more general question: what physical principle could be shared by primitive prebiotic systems...

Research Program Overview: Bioenergetics of Membrane Homeostasis in Open Cellular Systems

This document summarizes a theoretical research program proposing that maintenance of plasma membrane homeostasis can be understood as an integrated bioenergetic problem in an open nonequilibrium cellular system. The objective is not to replace molecular oncology but to provide a...

2. Critical Bifurcation in an Open Cellular System: A Theoretical Model of Membrane Homeostasis under Persistent Mechanical Stress

Living cells continuously consume energy to maintain membrane integrity, ionic gradients and bioelectric homeostasis. This paper proposes a theoretical nonlinear model describing how persistent nanoparticle-induced mechanical stress may progressively increase energetic demand unt...

1. A Bioenergetic Model of Membrane Homeostasis under Nanoparticle-Induced Mechanical Stress

Living cells continuously maintain the structural and functional integrity of their plasma membrane despite persistent exposure to mechanical, chemical, and environmental stress. Among emerging environmental factors, engineered and environmental nanoparticles represent a growing...

The Homeostatic Energy Trap: Persistent Nanoparticle Mechanical Stress Forces the Warburg Transition due to Acute ATP Depletion

Homeostatická energetická pasca: Pretrvávajúce mechanické napätie nanočastíc vynúti Warburgov prechod v dôsledku akútneho vyčerpania ATP 1. Úvod a formulácia problému Súčasný onkologický výskum sa vo veľkej miere zameriava na terapeutické intervencie v neskorých štádiách aktívnej...

The Homeostatic Energy Trap: Persistent Nanoparticle Mechanical Stress Forces the Warburg Transition due to Acute ATP Depletion

Homeostatická energetická pasca: Pretrvávajúce mechanické napätie nanočastíc vynúti Warburgov prechod v dôsledku akútneho vyčerpania ATP 1. Úvod a formulácia problému Súčasný onkologický výskum sa vo veľkej miere zameriava na terapeutické intervencie v neskorých štádiách aktívnej...