The article compares several major climate instability periods, including the Permian/Triassic extinction, the Eocene/Oligocene transition, and the onset of Northern Hemisphere glaciation. Across these events, the authors describe patterns in which rapid warming, physiological thresholds, and cascading ecosystem disruptions repeatedly reshaped life on Earth.

The authors also emphasize how the modern crisis differs: human activities such as habitat destruction, fragmentation, exploitation, and the unusually rapid pace of current warming reduce species’ ability to move to suitable conditions. They conclude that conservation efforts should be informed by how Earth’s climate system behaves over long timescales and by the role of functional losses.