Research works

Design, Synthesis, and Preliminary Investigation on the Mode of Action for a Series of Novel Antimicrobial Peptidomimetics

Abstract Over the years, many antibiotics have been developed, but most have become less effective due to antimicrobial resistance, especially those targeting enzymatic pathways. This growing resistance poses a serious global health threat. It is now recognized that physically di...

PNBind : Prediction of Nucleic Acid‐Binding Sites Using Protein Structure and Protein Language Models

ABSTRACT Accurate prediction of nucleic acid‐binding sites is essential for understanding protein function and facilitating drug discovery. However, current computational methods are limited by single‐layer language model representations, Cα point clouds that discard local‐frame...

Comparison of patient preference for and interpretability of video-based pain-expression scenarios and the numerical rating scale for postoperative pain assessment: a prospective observational study

Background: Postoperative pain assessment relies primarily on numeric self-report tools, such as the numerical rating scale (NRS); these tools require abstract numerical cognition and may be challenging for some patients in the immediate postoperative period. Thus, in this prospe...

Effect of Cyclodextrin Complexation on the Separation of Insulin Analogues in Capillary Electrophoresis Using Dynamically Coated Capillaries

The simultaneous separation of therapeutic insulin analogues by capillary electrophoresis (CE) remains challenging because of their high structural similarity and their tendency to adsorb onto the capillary surface. This study investigated the applicability of cyclodextrin (CD) d...

Adopters as a Scarce Resource: A Chemostat-like Approach to Single-Technology Diffusion

This paper models innovation diffusion trajectories within capacity-limited market niches. To overcome the structural limitations of classical phenomenological frameworks (Bass, Gompertz, and Mansfield models)—namely, rigidly fixed trajectory asymmetry and the lack of underlying...

Simultaneous obstacle avoidance and trajectory tracking for multi-robot systems via acceleration-level motion planning

Considerable attention has been directed toward collision-free trajectory tracking in multi-robot systems, for which CBFs have been widely adopted as a safety-critical tool. However, existing CBF methods are constrained by their dependence on maximum braking estimation. Moreover,...

Broader factors associated with current adolescent overweight/obesity status in YRBSS 2023: Survey-aware analysis and calibrated AI-assisted classification

Adolescent overweight and obesity are shaped by demographic, behavioral and psychosocial factors, but it remains unclear whether broader predictor information improves cross-sectional classification of current overweight/obesity status more consistently than changing the machine-...

Neural Repair Therapies After Stroke: I. Therapeutic Advances

Stroke is a leading cause of disability worldwide. Neural repair therapies, distinct from acute stroke therapies, target surviving neural elements to promote plasticity after the acute injury has occurred. Repair therapies encompass a broad and rapidly evolving therapeutic landsc...

Hydantoin Impurity Formation During Peptide N-Terminal Acetylation with Acetic Anhydride

Abstract Previously unreported N-terminal hydantoin and N-acetyl hydantoin impurities were observed during peptide N-terminal acetylation with acetic anhydride under commonly used base/solvent conditions. The impurities were isolated and structurally characterized by HRMS and NMR...

Spathology: The Birth of Spatial Pathology as a Discipline

Pathology has always been a spatial science: for more than 150 years, diagnosis has rested on reading the architecture of cells and tissues. Three technological streams are now converging on this founding principle. Spatially resolved omics can measure thousands of transcripts an...

The combined medication approach for treating overactive bladder: assessing safety and efficacy

Research question: What is the latest evidence on the efficacy and safety of combining medications to treat overactive bladder? The problem: Overactive bladder symptoms negatively impact quality of life and, with an ageing population, overactive bladder prevalence is expected to...

The evolution of relationship management from remote to hybrid work

Purpose This study explores how first-line managers adapt relationship management practices during the transition from onsite to remote and hybrid work amid prolonged uncertainty. Design/methodology/approach A longitudinal case study using temporal bracketing analyzed 49 intervie...

The Substrate Condensate: Formation, the Dark Gauge Gap, and Time Activation

One object does three things. This note derives the substrate condensate of Spectral Quantum Gravity from a single, explicitly fixed energy functional and follows the same condensate through two of its consequences. What is confirmed.By consistency: one condensate carries the dar...

Development of Sustainable Mortars and Concrete with Marine Sediment, Sea Sand and Seawater: A Review on Cement Hydration, Mechanical Strength, and Durability

Concrete production consumes vast quantities of natural aggregate and potable water, while coastal dredging produces hundreds of millions of cubic meters of underutilized marine sediments and sea sand annually. This study aims to provide a review on recycling dredged marine sedim...

Governing cognitive labor delegated to AI in scholarly writing and medical education

Abstract Across scholarly communication and medical education, AI-assisted writing redistributes cognitive labor. Mapping publishing policies from 2023 through 11 August 2026 finds governance centered on permitted uses, human authorship and accountability, disclosure, verificatio...

Constructing and negotiating boundaries between product management and project management in digital product environments

Purpose This paper examines how practitioners make sense of and negotiate boundaries between product management and project management in digital product environments, with particular attention to temporal orientations, governance interfaces, role accountabilities and decision ri...

Synthesis of Calcium Sulfate Nanocrystals via Confined Reaction in Ion-Enriched Instantaneous Microdomains

Abstract Hemihydrate calcium sulfate nanocrystals hold promising potential in biomedical and industrial applications. Conventional synthesis methods typically necessitate high temperatures/pressures, acidic/alkaline media, or expensive organic reagents. This study proposes a faci...

Observing Elusive Reaction Intermediates with Raman Spectroscopy via Melt-React-Trap

Abstract Understanding reaction pathways relies on detecting and characterizing reactive and short-lived intermediate species. Melt-React-Trap (MRT) is introduced as a technique to generate and identify such elusive species via Raman microscopy. This method combines the advantage...

Empowering Memorable Tourism Experiences: How Smart Tourism Technology Quality Shapes Destination Perceptions and Tourist Psychological Empowerment

Smart tourism technologies are increasingly transforming how tourists interact with destinations, yet the mechanisms through which technology quality contributes to memorable tourism experiences remain insufficiently understood. Drawing on Stimulus–Organism–Response (S-O-R) theor...

Multi-objective optimization of cylinder liner honing surface parameters for lubrication and wear properties based on BPNN–NSGA-II

Simultaneously enhancing oil film thickness while controlling wear load remains a key challenge in cylinder liner honing texture optimization, yet these performance indicators are typically optimized separately. This study proposes a simulation-driven multi-objective framework th...