Research works

Are UK Research Priorities Aligned? Comparing the Research Priorities of the Down Syndrome, Fragile X Syndrome and Williams Syndrome Communities, With the Research and Funding Landscape

ABSTRACT There is a lack of understanding of how research activity in learning disability compares with community research priorities in the United Kingdom, where an estimated 1.5 million people live with a learning disability. Using Down syndrome (DS), Fragile X syndrome (FXS) a...

Impact assessment of co-management strategies on forest ecosystem in protected areas of Bangladesh using remote sensing and GIS based analysis

Co-management of Protected Areas (PAs) has emerged as a strategy to make forest restoration and biodiversity conservation more effective by encouraging the active participation of local people. This study analyzed the co-management effects in two protected areas i.e. Dharmapur Sh...

Radiative recombination of near-surface donor–acceptor pairs in hydrogenated homoepitaxial diamond nanolayers

Hydrogen-terminated diamond is known for its p-type surface conductivity, which arises from a near-surface hole accumulation layer induced by adsorbed acceptor species. Here, we demonstrate that these surface acceptors also form optically active donor–acceptor pairs (DAPs) with s...

Monitoring the Use of Big Data in the Russian Healthcare System

Abstract The issues of monitoring and assessing the level of big data technologies use in the healthcare system of Russia have been investigated. A conceptual scheme and a system of indicators have been developed to monitor the level of maturity of big data technologies in the he...

The chemical-bonding origins of over-coordinated defects in chalcogenide glasses

Point defects in (sulfide, selenide) chalcogenide glasses have traditionally been described by the venerable ‘valence-alternation-pair’ (VAP) model of coordination defects, due to Mott, Davis and Street, and Kastner, Adler and Fritzsche. For the case of pure chalcogens (e.g. Se),...

Dystrophic changes of nigrostriatal axons harboring a SYNJ1 Parkinson’s mutation suggest catastrophic failure of endocytic mechanisms

Synaptojanin 1 is a brain enriched phosphoinositide phosphatase implicated in endocytosis at the synapse. A mutation (R258Q) that selectively impairs its Sac1 phosphatase domain causes early onset familial Parkinsonism. Neurons of mice with this mutation display synaptic vesicle...

Diagnosis of tuberculous lymphadenopathy: the role of droplet digital PCR

Background: Tuberculous lymphadenopathy (TB-LAP) is the most common form of extrapulmonary TB and remains diagnostically challenging due to its paucibacillary nature. We evaluated the diagnostic performance of droplet digital PCR (ddPCR) for detecting Mycobacterium tuberculosis (...

Variation in High Value Care for Low Back Pain Among Older Adults Enrolled in Medicare Advantage Plans

IMPORTANCE: Low back pain (LBP) is a major cause of disability and poor quality of life among older adults. Clinical guidelines recommend non-pharmacological therapies, such as physical therapy (PT), as the first-line treatment for high-value care. Despite the fact that more than...

Cu(I)-Photosensitizer Catalysis: A Tool for Conjunctive Olefination of Aldehydes

The development of novel methodologies for olefin synthesis remains a central objective in synthetic chemistry, as olefins represent ubiquitous building blocks and versatile precursors for downstream transformations. The conventional Wittig reaction relies on phosphonium salts as...

Output feedback stabilization of nonlinear switched systems via incomplete information

This paper addresses the challenging problem of output feedback finite-time stabilization for a class of nonlinear switched systems subject to digital signal constraints. Existing methods typically handle state observation, signal sampling, and quantization separately, leading to...

Transforming Gas Separations with Scalable Carbon Molecular Sieve Membranes Enabled by Chemically Tuned Hollow‐Fiber Precursors

ABSTRACT Blending hydrogen into natural gas pipelines requires efficient separation, while helium recovery from natural gas via cryogenic distillation is energy‐ and capital‐intensive, driving demand for better membranes. This study develops ultraselective carbon molecular sieve...

Nitrogen-doped MOF-derived carbon hosts for aluminum-sulfur batteries: Polysulfide confinement and sulfur-loading limitations

Despite being a highly attractive candidate for advanced energy storage systems, aluminum‑sulfur (Al S) batteries suffer from restricted practical viability due to severe polysulfide shuttling and inherently slow redox kinetics. To tackle these issues, a ZIF-67-templated hierarch...

Bidirectional Mediation Effects of Body Mass Index and Inflammatory Markers on Assisted Reproductive Outcomes in Women With Polycystic Ovary Syndrome

OBJECTIVE: To evaluate the bidirectional mediation effects of body mass index (BMI) and inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII], platelet-to-lymphocyte ratio [PLR]) on assisted reproductive technology (ART) outcomes in...

Consciousness as Fundamental Force: Philosophical Claims, No Mathematical Derivation — E8 Intelligence Research

FINDING: Consciousness-as-fundamental-force arguments are philosophically framed, not mathematically derived; the sole quantitative paper (arXiv:physics/0409140v2) offers a many-body effective-potential formalism but no consciousness-specific equations. | MATH: No closed-form con...

Research on solid-state battery information mining based on large language models and chain-of-thought reasoning

Solid-state batteries (SSBs) represent a next-generation energy storage technology. However, the wide diversity of solid-state electrolyte (SSE) chemistries, coupled with the complexity of their synthesis and processing routes, makes systematic investigation, knowledge reuse, and...

Simplification and Derivatization of Quinoline-Containing M41 Lead to the Discovery of NADPH Oxidase Isoform-Selective Inhibitors Effective in Cancer Cells

Abstract NADPH oxidases (NOXs) are attractive but challenging drug targets. Starting from M41 and its analog MC4876, we synthesized quinoline-based derivatives. SAR studies revealed that modifications at the quinoline C2 position and the amine-moiety influenced potency and isofor...

Adaptive Re-Screening and Pair-Screened Joint Rescue for Scalable Stepwise Selection in Cross-Classified Linear Mixed Models

Stepwise fixed-effect selection in complex linear mixed models is expensive because each candidate can require the re-estimation of variance components. Permanent pruning lowers this cost but can discard predictors that become relevant after other terms enter. We propose adaptive...

Phi-Hierarchical E8 Error Correction via Fibonacci 132Hz Frequency Cascades — E8 Intelligence Research

The 240 E8 root vectors naturally decompose into Fibonacci-weighted layers—128 roots forming power-of-2 structured correction frames and 112 φ-modulated roots encoding information—enabling a hierarchical error correction scheme that mirrors the 1, 2, 3, 5, 8, 13... Fibonacci sequ...

Service-level and practitioner-level recommendations for better care of people with dementia who live alone and have no informal caregivers

Context A substantial proportion of people with dementia live alone without informal caregivers, yet services often assume family involvement, increasing risks of unmet need and adverse outcomes. Objective This study aimed to generate service-level and practitioner-level recommen...

ALIX-dependent small extracellular vesicles from tissue-resident mesenchymal cells regulate pancreatic β cell proliferation in obesity

Cells throughout the body release small extracellular vesicles (sEVs), including exosomes, that function as modulators of both local and systemic metabolism. Using mice in which ALIX, a key regulator of sEV biogenesis, was selectively deleted in PDGFRα + mesenchymal progenitors (...