Research works

Knowledge design in complex domains

Traditional Knowledge Engineering (KE) often fails to address modern complex domains characterized by "wicked problems," where non-stationary ground truths and high dimensionality render static rule sets obsolete. This paper proposes a paradigm shift from traditional Knowledge En...

Cysteine preconditioning improves post-freeze-thaw proliferative capacity of human synovial mesenchymal stem cells

<title>Abstract</title> Background Synovial mesenchymal stem cells (MSCs) are promising for cartilage regeneration; however, freeze–thaw injury during cryopreservation impairs their proliferative capacity and may limit therapeutic efficacy. Glutathione, a key intracellular antiox...

The Kantian Peace Machine: Toward a Mechanism-Design Framework for Institutional Peace

Abstract (English) How can institutional design transform a security dilemma into a stable peace equilibrium? This paper proposes a Kantian mechanism-design framework that maps Kant's Toward Perpetual Peace onto a four-layered architecture: objective function, feasibility constra...

Mass–Energy Equivalence as a Constraint Surface and Its Dimensional Embeddings

Einstein's mass–energy relation E=mc² is, as physics, a constraint among three positive scalars. This preprint develops it as a theory of embeddings: the constraint surface S ⊂ ℝ³ is a smooth saddle; a stated filling operator Φ places S uniquely into a 15-dimensional bookkeeping...

A Multi-Component Deep Learning Approach for Cyber-Attack Detection in Critical Infrastructure SCADA Systems

<title>Abstract</title> Industrial control networks based on Supervisory Control and Data Acquisition (SCADA) systems used in critical infrastructure systems require reliable, scalable, and generalisable attack detection mechanisms in the face of increasing cyber threats. However...

Atmospheric forcing and ocean preconditioning for dense shelf water cascading in the northwestern Mediterranean

<title>Abstract</title> Dense shelf water cascading (DSWC) in the northwestern Mediterranean Sea occurs due to the densification and overflow of shelf water in winter. This process ventilates the deep basin with waters that can be denser than those generated by open-ocean convect...

A Social Network Analysis of the 1485 Innsbruck Inquisition

This node and these edge sheets are the data informing my upcoming publication in the _Sixteenth Century Journal_ and my current book project.

Bayesian Inference for the Automultinomial Model With an Application to Landcover Data

ABSTRACT Multicategory lattice data arise in a wide variety of disciplines such as image analysis, biology, and forestry. We consider modeling such data with the automultinomial model, which can be viewed as a natural extension of the autologistic model to multicategory responses...

Spatial exclusion on public land: Fragmented governance and Vancouver's golf courses

Cities face growing pressure to justify how scarce urban land is allocated and whose needs it serves. This article analyzes spatial exclusion in Vancouver, British Columbia, a Canadian city under housing and land-use pressure. The analysis centers on municipal golf courses as an...

Toward Agent-Based Educational Science: Rethinking Educational Research in the Age of AI

Educational science faces a structural mismatch between the pace of educational innovation and the methods used to evaluate its developmental impact. While new pedagogical approaches and AI-driven learning technologies are rapidly deployed, the empirical paradigm of classroom-bas...

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

Abstract C-type lectins (CTLs) play key roles in innate immunity and microbial carbohydrate recognition. In the disease vector mosquito Aedes aegypti , the CTLD-S family comprises 34 soluble CTLs whose members are implicated in flavivirus dissemination and microbial homeostasis,...

Failure to track a stable AMOC state under rapid climate change

Abstract The Atlantic Meridional Overturning Circulation (AMOC), a tipping element of the climate system, currently has an estimated global warming threshold for collapse of +4.0 °C (uncertainty range 1.4–8 °C). However, such a threshold may not be meaningful because AMOC stabili...

Fostering reflection: Development and initial evaluation of a mentalization-based GenAI simulator for foster care supervisors

Background Foster care supervisors require advanced reflective functioning (RF) to manage complex relational demands, yet traditional training is difficult to scale and access. Generative AI (GenAI) may help by enabling simulated practice environments. Objective This feasibility...

Effectiveness of Clazosentan Combined with Ozagrel for Aneurysmal Subarachnoid Hemorrhage: A Retrospective Comparative Study

Abstract Clazosentan, a selective endothelin A receptor antagonist, has recently emerged as an essential therapy for aneurysmal subarachnoid hemorrhage (aSAH) in Japan. However, evidence regarding combination therapy with adjunctive agents remains unclear. We retrospectively comp...

Integrated population-based evidence, network toxicology, single-cell profiling, and in vitro studies elucidate mechanisms connecting PAHs to stroke

Environmental exposure to polycyclic aromatic hydrocarbons (PAHs) has been associated with cardiovascular disease, yet the specific metabolites and cell-type-resolved mechanisms underlying stroke risk remain poorly defined. Here, we applied an integrated multilevel framework comb...

From Structureto Dynamics: Activation Mechanism ofthe G Protein-Coupled Bile Acid Receptor 1-Gs Complex

Abstract The G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) is a key mediator of bile acid signaling, exerting its physiological effects through coupling with the stimulatory G protein (Gs). This interaction stabilizes the receptor’s active state and triggers...

Denoise Stepwise Signals by Diffusion Model‐Based Approach

ABSTRACT Stepwise signals are ubiquitous in single‐molecule detections, where abrupt changes in signal levels typically correspond to molecular conformational changes. However, these features are inevitably obscured by noise, leading to uncertainty in estimating both signal level...

The NtAN3 gene plays a key role in increasing tobacco leaf area

Tobacco (Nicotiana tabacum L.) is an important cash crop, and the size of its leaves significantly influences both yield and quality. However, previous research often focused on cultivation measures to enhance yield and quality, while the study of the structure and function of ge...

Morphology of third mandibular molars – an in vivo cone beam computed tomography study in Lower Silesia

<title>Abstract</title> Background Understanding the root and canal morphology of mandibular third molars (MTMs) is crucial for anatomical characterization of human dentition and effective endodontic treatment. This study investigates the number of roots, canal configurations, an...

Total Synthesis of Paliurine E by a Highly Convergent Block Approach

ABSTRACT Macrocycles occupy a privileged position in chemistry, biology and medicine, yet their broader exploitation is curtailed by the lack of general, efficient synthetic strategies. Current approaches to macrocycle construction rely largely on stepwise linear assembly, protec...