Research works

Neuropathy With Demyelinating Features in a Patient With Biallelic HARS1 Variants

ABSTRACT Background and Aims The HARS1 gene encodes cytoplasmic histidyl‐tRNA synthetase, which catalyzes the ligation of histidine to tRNA HIS in the cytoplasm as an early step in protein biosynthesis and is essential for cell viability. Pathogenic variants in HARS1 have been as...

Long-Lived Interfacial Charge Separation in PyrenylimidazolylPhthalocyanine@Transition Metal Dichalchogenide Heterostructures

Abstract Pyrenylimidazolyl-functionalized free-base phthalocyanines (H2Pc) and their zinc complexes (ZnPc) constitute multifunctional building blocks for realizing heterostructures with liquid phase exfoliated transition-metal dichalcogenides (LPE-TMDs). Here, we report the synth...

Regulatory Role of Adrenomedullin in Hypoxic Adaptation of Yak Subcutaneous Preadipocytes

High-altitude hypoxic environments constrain yaks’ survival capacity and metabolic adaptability. Subcutaneous adipose tissue helps yaks withstand cold and resist hypoxic stress, and ADM participates in cellular stress and metabolic regulation. To explore the regulatory role of AD...

Does plastic waste present an infection hazard? Current evidence, surveillance challenges and research priorities

Abstract Unmanaged plastic waste is widespread in settings with limited waste collection, yet its contribution to infectious disease risk remains poorly understood. In this review, we synthesise current evidence on the human health implications of plastic waste, with a specific f...

Numerical Study on the Stability of a Riprap for Submarine Cables and the Protective Solution Under Waterflow Incidence

This study presents a numerical investigation into riprap stability for submarine cable protection under high-speed incident waterflow conditions. A coupled CFD-DEM numerical model, implemented within the ANSYS 2024 R1 platform, was developed and validated against controlled labo...

Evaluating employees’ positive functioning at work: Adaptation and validation of the PERMA+4 scales in the Italian context

As positive psychology continues to gain prominence in organizational contexts, scholars are calling for more cross-cultural investigations into how well-being frameworks translate across different cultural contexts. This study validated both the brief and extended versions of th...

Development and Evaluation of a University-Based External Coaching Program for School Behavioral Health

School behavioral health (SBH) systems coaching is a developing approach to implementation support for the delivery of high-quality behavioral health support in schools through a multi-tiered prevention and intervention framework. Articulating coaching components and understandin...

Reflexivity in practice: integrating participatory action research and behavioral science in youth substance use prevention

Background This study integrated behavioral science and participatory action research to co-design an illicit substance use prevention campaign with young people in Kirklees, United Kingdom. The project sought to explore how these approaches could be combined to create health com...

AAIS Phase XI: The Observable Bridge — From Theoretical Structures to Experimental Validation

Phase XI: The Observable Bridge — Physical Interface, Validation, and Experimental Architecture This release presents Phase XI of the AAIS (Artificial Asymptotic Information Structure) framework. Its primary objective is to establish a rigorous and transparent pathway from theore...

Global trends in pleural infection mortality: a WHO-mortality database analysis

Background Current data suggest that the incidence of pleural infection is rising worldwide, however mortality data on global rates, trends and variations are lacking. Objectives To estimate pleural infection mortality rates across 24 Countries from 1994 to 2020 worldwide, using...

Oceans as vortex electromagnetic machines: El Niño, the Gulf Stream and the circulation of the Atlantic

Developed within the interdisciplinary framework of The Reconceptualization Epoch project, this paper introduces a radical electrodynamic and natural-philosophical model of global ocean circulation. The author deconstructs conventional hydrodynamic paradigms, proposing that major...

The morpho-syntax of Standard Scottish English

Abstract With empirical research on Standard Scottish English showing a bias towards phonology, the aim of the current study is to contribute to the morpho-syntactic documentation of this variety. Relying on Standard Southern British English for comparison, we concentrate on four...

Examination of Online Learning Strategies With Cluster Analysis

ABSTRACT The aim of this study is to identify the learning strategies of students taking e‐courses in e‐learning environments using clustering algorithms, a data mining technique and to determine how these strategies are distributed according to the variables gender, class, facul...

Disturbance-Aware Preview Control for Humanoid Robot Towing of Heavy Wheeled Loads with Traction Force Compensation

Most existing humanoid robots possess a payload capacity below 10 kg, which is insufficient for practical material transport tasks. A natural engineering solution is to enable humanoid robots to tow wheeled trailers or hand carts, transferring the vertical load to the wheeled car...

Self-Subliminal Therapy for Adolescent Major Depressive Disorder with School Refusal: An 18-Month Longitudinal Case Study

AbstractBackground: Adolescent depression has reached epidemic proportions in urbanChinese cohorts, with prevalence estimates exceeding 20% in some regions. Standard interventions achieve only partial remission in a substantial minority of cases,and treatment resistance is especi...

Genetic distance and pollinator sharing shape divergence in floral volatiles in closely related dioecious Ficus species

Abstract Premise Floral scent is central to host recognition in the fig–fig wasp mutualism, yet how scent divergence relates to pollinator sharing among closely related dioecious Ficus species remains unclear. Methods We analyzed volatile organic compounds (VOCs) from four pairs...

Frobenius-Polynomial Second-Order Linear Differential Equations: Structure and Recognition in the Real-Indicial Case

We study equations y′′+P(x)y′+Q(x)y=0, with P,Q∈C(x), that admit two linearly independent local solutions y1=xrA(x) and y2=xsB(x) at the regular singular point 0, where A and B are polynomials and A(0)B(0)≠0. We call these Frobenius-polynomial type (FP) equations and focus on the...

The Metabolic Revolution in Dermatology: Obesity, Insulin Resistance, and Ultra-Processed Diets as Drivers of Skin Inflammation

Inflammatory dermatoses are increasingly linked to systemic metabolic factors. Obesity and insulin resistance create a pro-inflammatory milieu that affects the skin. Adipose tissue functions as an endocrine organ secreting adipokines and cytokines that drive chronic inflammation...

A novel method of manipulation and immobilization with the wrist dorsiflexed for distal radius fractures: short-term outcomes

Distal radius fractures (DRFs) are the most common fractures in adults. For displaced DRFs, casting after successful closed reduction remains a standard treatment. The optimal wrist position during casting has been discussed extensively, with dorsiflexion shown to help prevent re...

Boosting PEMWE Performance Via the Local Electronic Regulation of Ir 0.5 Ru 0.5 /NbN Catalyst With Synergistic Vacancy and a Doping Engineering Strategy

ABSTRACT Proton exchange membrane water electrolysis (PEMWE) is an environmentally friendly and efficient technology for hydrogen production, playing a vital role in mitigating the fossil energy crisis and bridging renewable energy generation with hydrogen utilization. This work...