Research works

Exploring Training Needs to Facilitate Shared Decision Making in Juvenile Idiopathic Arthritis Symptom Management and the Use of the JIA Option Map

Objectives Our team developed the JIA Option Map, a web-based patient decision aid (PDA) designed to support shared decision-making (SDM) for juvenile idiopathic arthritis (JIA) symptom management. Since training for health care providers (HCP) can enhance SDM and the use of PDAs...

TDE or Emission? Testable Predictions for TDE 2025abcr from the Spiral Classification of Elements

Abstract. TDE 2025abcr (Stein et al. 2026) is the most offset tidal disruption event ever optically detected — 9.08 kpc from the nucleus of WISEA J014656.04-152214.7, with no visible progenitor source at the position (m > 23.78). The spectrum shows broad H and He II lines with a...

Engineered microorganisms for environmental release: current situation and future perspectives

Engineered microorganisms for environmental release (EMERs) hold a considerable potential for bioremediation of sites polluted with urban and industrial emissions. The growing availability of EMERs with phenotypes that can help recovering polluted sites and degraded ecosystems co...

Penrose Tiling: Aperiodic Order via Golden Ratio Rhombi Explaining Quasicrystal Diffraction — E8 Intelligence Research

FINDING: Penrose tiling enforces aperiodicity via matching rules on two rhombi (72°/108° and 36°/144°), generating 5-fold rotational symmetry forbidden in periodic crystals, and directly explains quasicrystal diffraction patterns. MATH: - Rhombus angles: 72° (π/5), 108° (3π/5); 3...

The Tanfarid Quantum Thermodynamic Universe (TQTU)- A Complete Plasma-Thermodynamic Resolution of Galactic Rotation Curves Without Dark Matter

For more than five decades, the discrepancy between observed galactic rotation velocities and predictions from visible baryonic matter has been attributed to dark-matter halos. No direct detection of a non-baryonic dark-matter particle has been achieved. This paper presents a com...

8.16 Cosmic Cycle Scaling

We independently derive the time scale system of the material world, clarifying the three levels of geometric theory — total universe, region, and three worlds. Core achievements: the scaling period is a theorem-grade formula; the small cycle ten-thousand years, the mid cycle hun...

8.18 Galaxy Rotation Curves and Falsification of Dark Matter

Starting from the ℳ𝒞ℐ Three-Sector and Coding Orbit compactification, combined with the Permeation Function elliptic PDE framework, this article establishes the nonlinear correction to gravity at galactic scales induced by three-dimensional coherent leakage of the Information Fie...

The Six-Neuron Counterexample to the Target-Free Clique Conjecture Is Minimal

This record presents an exact, independently replayable computer-assisted proof that every legal combinatorial threshold-linear network (CTLN) on at most five neurons satisfies the algebraic target-free clique classification. Consequently, every nondegenerate legal CTLN on at mos...

Dynamic feature pyramid network for real-time gesture recognition

Effective gesture recognition in Virtual Reality (VR) and Augmented Reality (AR) faces significant challenges from varying hand angles, postures, and complex backgrounds, limiting real-time application potential. This paper proposes the Dynamic Feature Pyramid Network (DFPN), a n...

Penrose Tiling: Aperiodic Order via Golden Ratio Rhombi Explaining Quasicrystal Diffraction — E8 Intelligence Research

FINDING: Penrose tiling enforces aperiodicity via matching rules on two rhombi (72°/108° and 36°/144°), generating 5-fold rotational symmetry forbidden in periodic crystals, and directly explains quasicrystal diffraction patterns. MATH: - Rhombus angles: 72° (π/5), 108° (3π/5); 3...

Wave Decay with Singular Damping

We consider the stabilization problem on a manifold with boundary for a wave equation with measure-valued linear damping. For a wide class of measures, containing Dirac masses on hypersurfaces as well as measures with fractal support, we establish an abstract energy decay result.

Alternative polyadenylation in cancer: mechanisms, functions, and therapeutic potential

Alternative polyadenylation (APA) is a pervasive post-transcriptional regulatory mechanism that generates transcript isoforms with distinct 3′ untranslated regions, terminal exons, or coding potential, thereby influencing mRNA stability, translation, localization, and protein out...

Doctrine of Signatures in Homoeopathic Materia Medica: A Review

The Doctrine of Signatures is an ancient philosophical concept proposing that the external appearance, colour, shape, habitat, or other natural characteristics of plants, minerals, and animals indicate their potential therapeutic uses. Although the doctrine predates homoeopathy b...

7.3 Fine-Structure Constant

This article proves that the Fine-Structure Constant is a coordinate reading on the Landscape of Conjugate Spectral Geometry. The Algebraic Action at the fixed point of the Observer Localization yields , with a deviation of approximately from the CODATA experimental value . is a...

EuroMillions Breakthrough Mining — 948 Sources, 4925 Leads Extracted — E8 Intelligence Research

Mined 948 lottery+quantum breakthroughs. Extracted 4925 leads across 13 categories. 3124 high-value leads found. Categories: {"CORRIDOR": 367, "FORMULA": 226, "GEOMETRIC": 634, "FORWARD_ATTEMPT": 381, "QUANTUM": 596, "TIMING": 160, "CELESTIAL": 311, "GEMATRIA": 344, "CONSTANT": 3...

The External Cortex Loop: Contingency Interruption, Reinstatement, and Cognitive Incorporation in EEG Neurofeedback

This theory-and-methods paper proposes a causal assay for deciding when a person-specific EEG-to-sensory feedback process has become functionally incorporated into a learned operation. Participants acquire a live mapping, undergo concealed sensory-matched contingency interruption...

Exploring Decisional Factors to Include Approaches in a Patient Decision Aid for Juvenile Idiopathic Arthritis Symptom Management

Objectives Youth with juvenile idiopathic arthritis (JIA) experience physical and mental health symptoms that negatively impact their participation in daily life activities. The JIA Option Map is a web-based patient decision aid (PDA) created to facilitate decision-making for JIA...

Patient Perspectives on Industry Sponsored Patient Support Programs for Advanced Therapy in Rheumatology

Objectives Industry sponsored rheumatology patient support programs (PSPs) for advanced therapies (ATs) are commonplace. While there is limited data to demonstrate their effectiveness in patient care, patient perspectives are even more lacking. This study aims to report patient v...

DNA methylation of silencer-annotated regions at the MGMT locus in the context of promoter and enhancer methylation in glioblastoma and melanoma brain metastases

Abstract Background MGMT promoter methylation is a well-established biomarker in glioblastoma, its relevance in melanoma brain metastases remains controversial. Recent studies indicate that methylation of MGMT enhancers contributes to MGMT regulation, whereas the role of silencer...

Not just alignment: body shape influences adult spinal deformity biomechanics

Abstract Purpose Adult spinal deformity (ASD) alters sagittal alignment and trunk centre of mass location, increasing spinal loading. Current clinical assessment of ASD primarily focuses on alignment parameters disregarding patient’s body shape variability. This study aimed to ev...