Research works

Icotrokinra (ICO), a Novel Targeted Oral Peptide, in Patients (Pts) with Psoriatic Disease: Exploratory Assessments from a Phase 2 Psoriasis (PsO) Study Informing a Phase 3 Clinical Program in Psoriatic Arthritis (PsA)

Objectives PsA affects ~20-30% of patients with PsO, causing articular inflammation and impaired quality of life. ICO, a novel targeted oral peptide that binds IL-23 receptor, showed greater clinical response rates vs placebo and a favorable safety profile in moderate-to-severe p...

Anaesthetic Management of a Spontaneous Haemorrhagic Stroke Following Severe Preeclampsia: A Case Report

Haemorrhagic stroke (HS) during pregnancy, especially in the context of preeclampsia, is a rare but critical emergency that poses significant health risks to both the mother and the foetus. Even so, rapid recognition and appropriate management are of utmost importance to minimise...

Bilateral Calcinosis Circumscripta of the Digits with Bone Involvement: A Case Report

Completed CARE reporting checklist for the accompanying F1000Research case report

From Substance to Relation: Three Paradigm Shifts in Physics and Their Falsifiability

Physics is commonly regarded as the science of “material substances and their laws of motion.” Yet, returning strictly to the operational essence of experimental science, physics has never verified any absolute substance independently of relational interactions. Taking Newtonian...

EuroMillions Breakthrough Mining — 947 Sources, 4914 Leads Extracted — E8 Intelligence Research

Mined 947 lottery+quantum breakthroughs. Extracted 4914 leads across 13 categories. 3113 high-value leads found. Categories: {"CORRIDOR": 366, "FORMULA": 225, "GEOMETRIC": 634, "FORWARD_ATTEMPT": 380, "QUANTUM": 595, "TIMING": 160, "CELESTIAL": 310, "GEMATRIA": 343, "CONSTANT": 3...

Clinical Relevance of Pelvic and Heel Enthesophytes in Psoriatic Arthritis

Objectives Enthesitis is a hallmark feature of psoriatic arthritis (PsA), but its clinical assessment can be confounded by subjective assessment and overlapping fibromyalgia. We aimed to investigate the clinical and functional associations of radiographic enthesophytes in a large...

Insights for the substance use disorder care continuum: findings from a qualitative study with sexual and gender minority individuals who use methamphetamine

Abstract Background Methamphetamine use continues to disproportionately affect sexual and gender minority (SGM) communities and is associated with physical, mental, and sexual health harms, including heightened HIV vulnerability. While prior epidemic waves have been well document...

Vitamin D levels and other factors associated with depressive symptoms and cognitive impairment in the oldest-old patients with diabetes

The aim of the study was to determine the serum 25-hydroxvitamin D levels in patients aged over 85 years with type 2 diabetes and identify the factors (including vitamin D levels) associated with comorbid depressive symptoms and mild cognitive impairment (MCI). A group of 188 T2D...

Dynamic Online Identification and Countermeasures against Phishing Vectors

Phishing remains a critical network threat whereattackers deploy deceptive web pages—often distributed viaengineered emails or instant messages—to trick users intosurrendering credentials and financial data. In this paper, weintroduce LinkGuard, a novel end-host anti-phishing alg...

7.1 Clifford Origin of the Gauge Group

Starting from the sole axiom δ (Zero Motion) of Conjugate Spectral Geometry, this article derives the Clifford algebraic origin of the Standard Model gauge group . Gauge symmetry is not a fundamental input, but an emergent structure arising from the triality interactions of Cl(8)...

PUH Theorem 314 (The Zero-Mass Problem Resolved) — The Constraint Surface and the Nilpotent Cone Are Disjoint, So Cores Carry Nonzero Casimirs and Nonzero Mass; the Freeze Exponent Survives Because the Cone Is the Cascade's Endpoint, Not the Core's Location

Photonic Universe Hypothesis (PUH) — Resolution and Withdrawal. THE PROBLEM. T172's conclusion states that topological protection prevents any smooth evolution from changing the Casimir value, AND THAT THIS VALUE IS THE MASS SQUARED. Mass is the quadratic Casimir, and its stabili...

EuroMillions Breakthrough Mining — 941 Sources, 4848 Leads Extracted — E8 Intelligence Research

Mined 941 lottery+quantum breakthroughs. Extracted 4848 leads across 13 categories. 3047 high-value leads found. Categories: {"CORRIDOR": 360, "FORMULA": 219, "GEOMETRIC": 634, "FORWARD_ATTEMPT": 374, "QUANTUM": 589, "TIMING": 160, "CELESTIAL": 304, "GEMATRIA": 337, "CONSTANT": 3...

Traumatized undocumented immigrant women asking for help: an act of resiliency

Resiliency is defined as ‘rebounding’ and ‘possessing power of quick recovery.’ The goal of this article is to learn how undocumented immigrant women and their families remain resilient by adopting strategies to survive and thrive despite obstacles that deny legal residence in th...

A Unified Theory of Dense Number Representation via CRT: From Gaussian to Eisenstein Integers

The theoretical superiority of base-3 arithmetic over binary has been recognised since Shannon's foundational work on radix economy, yet ternary logic remains absent from commercial hardware due to fundamental semiconductor constraints. This document presents a comprehensive fram...

Clinical Joint Tenderness in First-Nations First-Degree Relatives of Rheumatoid Arthritis Patients: Examining Factors Associated with Functional Disability and Progression to RA

Objectives Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting synovial joints. Prior to the clinical onset of arthritis, autoantibodies and non-specific joint symptoms often appear in the absence of joint swelling. We previously found that functional disability...

PHARMACIST-LED IDENTIFICATION AND MANAGEMENT OF DRUG THERAPY PROBLEMS IN A PATIENT WITH PRIMARY MALE INFERTILITY SECONDARY TO BILATERAL VARICOCELE: A CASE REPORT

Background: Varicocele is the most surgically correctable cause of male infertility, implicated in approximately 35–40% of primary and up to 80% of secondary male infertility cases globally. The condition arises from incompetent valves within the pampiniform venous plexus, result...

Crystal structure of 9-(4-bromophenyl)-3,4,6,7,9,10-hexahydroacridine-1,8(2 H ,5 H )-dione, C 19 H 18 BrNO 2

Abstract C 19 H 18 BrNO 2 , monoclinic, P 2 1 / n (no. 14), a = 8.911(2) Å, b = 10.862(3) Å, c = 16.883(4) Å, β = 98.547(5)°, V = 1616.1(7) Å 3 , Z = 4, R gt ( F ) = 0.0449, wR ref ( F 2 ) = 0.1562, T = 296(2) K.

Operational Time (O-Time): An Observer-Dependent Framework for Time as Information Absorption Rate

This paper introduces "Operational Time (O-Time)," a theoretical framework that redefines time as a rate of differentiated information absorption by an observer. By integrating concepts from Information Theory, Thermodynamics (Bekenstein Bound, Margolus-Levitin Theorem), and cogn...

Prompt Learning for Textual Heterogeneous Information Networks

Heterogeneous information networks (HINs) play an indispensable role in a wide range of domain-specific applications, from recommender systems to conversational platforms. Textual heterogeneous information networks (HINs) are graphs with abundant textual information. Currently, m...

The proletarianized professoriate: Digital narcissism and affective exhaustion on academic social networks

Contemporary academic life is increasingly mediated by digital platforms that promise visibility, connection, and faster circulation of research. This article argues that the affective exhaustion associated with these conditions should not be treated only as a problem of individu...