Research works

Establishment and genomic validation of novel patient-derived xenograft models for drug discovery in gastrointestinal stromal tumor

Abstract Most gastrointestinal stromal tumor (GIST) patients develop clinical resistance to approved tyrosine kinase inhibitors (TKI). The development of effective treatment strategies for refractory GIST requires identification of novel targets for investigational agents and wel...

Mistreatment during facility-based childbirth in Benin City, Nigeria: A convergent mixed-methods study of prevalence and drivers

Abstract Background Mistreatment during facility-based childbirth undermines maternal health outcomes and trust in health systems, particularly in low- and middle-income countries. Nigeria bears one of the highest global burdens of maternal mortality, yet limited large-scale mixe...

Job Skills and Occupations: PRISMA 2020 Systematic Literature Review Screening and Analysis Dataset

This dataset contains the complete screening, eligibility assessment, relevance scoring, thematic classification, and methodological synthesis used in a systematic literature review on job skills and occupations. The review follows the PRISMA 2020 framework and is based on record...

Liver Transplantation for Nonresectable Colorectal Liver Metastases

OBJECTIVE: To determine if stringent selection criteria could result long-term overall survival and to determine the proportion of patients that most likely were cured by the transplantation. SUMMARY BACKGROUND DATA: Liver transplantation is a potentially curative option for pati...

Firm Growth and Financial Performance of Listed Consumer Goods Firms in Nigeria: The Role of Turnover, Equity and Total Assets

Firm growth is often interpreted as an indicator of corporate strength, yet expansion in sales, equity, and assets does not necessarily translate into superior profitability. This study therefore shifts the focus from the magnitude of firm growth to the quality and profitability...

Incidence and risk factors for rotator cuff retear after arthroscopic rotator cuff repair in middle-aged and older patients: a systematic review and meta-analysis

Abstract Background Rotator cuff retear remains a major challenge after arthroscopic rotator cuff repair (ARCR), particularly among middle-aged and older patients. This study aimed to investigate the incidence of retear and identify its associated risk factors in this patient pop...

Causal beliefs and behavioural self-evaluation in cardiac rehabilitation: a cross-national study in the United States and Japan

Abstract Background Patients with established cardiovascular disease (CVD) continue to face substantial residual risk of recurrent events despite optimal medical management. Beliefs about disease causation, particularly attribution to genetic versus lifestyle factors, may influen...

The Structural Mechanics of Geo-political Entanglement

This commentary research paper analyzes the critical geopolitical escalations in the Strait of Hormuz during April 2026, focusing on the strategic deployment of naval mines by Iran. It explores the thesis that the seemingly haphazard placement or "misplacing" of these mines was a...

THE IMPACT OF SUSTAINABILITY REPORTING ON FAIR VALUE MEASUREMENT: EVIDENCE FROM LISTED COMPANIES IN GHANA

The growing call for corporate transparency, accountability, and sustainable business practices is reshaping how organizations report their activities around the globe. Sustainability reporting has become a key way for companies to share their environmental, social, and governanc...

AN INVESTIGATION OF LOAD FLOW SOLUTION METHODS IN POWER SYSTEM: A CASE STUDY OF NIGERIAN 330KV TRANSMISSION NETWORK

The main objective of a modern electrical power system is to provide quality and reliable electric power to consumers of electricity; the quality is determined by the voltage magnitude and the frequency at which it is delivered. Load flow analysis is essential for power system pl...

Multidisciplinary Approaches to the Management of Spinal Care: A Narrative Review

Abstract For patients with spinal care conditions including degenerative disease, deformity, traumatic injury, and complex pain syndromes, care is frequently fragmented across multiple specialists. This process can delay diagnosis, create complexity in communication, and result i...

COMPARATIVE ANALYSIS OF EARLY VERSUS DELAYED ENDOVASCULAR COILING FOR RUPTURED INTRACRANIAL ANEURYSMS: CLINICAL OUTCOMES AND PRE-PROCEDURAL STRATEGIES

Abstract Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a critical neurologic emergency with high mortality and disability. Prompt aneurysm securing is essential to reduce the risk of rebleeding, yet the optimal timing of endovascular coiling remains debated—especially...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

A spatially discretized convolutional neural mass model for studying meso-scale spatio-temporal transformations in the rat hippocampus

The brain operates across multiple spatial and temporal scales, necessitating computationally efficient models that link micro-scale mechanisms to meso- and macro-scale dynamics. Here, we introduce a novel convolutional neural mass model (CNMM) that computes the meso-scale activi...

PROSECUTING CORRUPTION IN AFRICA: CASE STUDY OF KENYA, ZAMBIA, NIGERIA AND SOUTH AFRICA

Corruption prosecution in Africa continues to face difficulties even though many more laws and institutions are being put in place. Although the majority of nations in Sub-Saharan Africa have enacted legislation against corruption and formed organizations aimed at tackling corrup...

THE INFORMATIONAL-QUANTUM PARADIGM OF THE COSMOLOGICAL CYCLE: AXIOMATIC SCALE-NORMING OF THE PREGEOMETRIC NETWORK AND THE ENTANGLEMENT-DENSITY NATURE OF GRAVITATION AND MASS

[Update Aug 2026]: Paradigm v9.0 added, featuring 5D Extended Sokolov Tensor and Core Operator classification.[Update July 2026]: Paradigm v8.0, incorporating Triple Cross-Scale Verification and Cognitive Mining Law.[Update July 14, 2026]: Paradigm v6.0, introducing QFT mass matr...

Combination of Bauhinia monandra extract and laser acupuncture reduces carrageenan-induced paw edema

PURPOSE: To investigate the anti-inflammatory effect of the ethanolic extract of Bauhinia monandra Kurz (EEB) alone and combined with laser acupuncture (LA) in a carrageenan-induced paw edema model. METHODS: EEB was characterized using HPLC-HRMS and tested for cell viability and...

Shifting the Paradigm: From ‘Best Practice’ to ‘Best Beliefs’ for Autism Within Inclusive Early Childhood Education

Abstract This study explores the role of early childhood teachers’ beliefs in shaping inclusive practices for autistic children within Australian early childhood education and care (ECEC) settings. While national frameworks such as the Early Years Learning Framework (AGDE, 2022)...

The business of play: careers and earnings in elite esports

Abstract Esports has emerged as a major sector of the global entertainment industry, with prize structures designed by tournament organisers and game publishers that concentrate rewards on a small elite. We analyse career duration and prize earnings using a 1999–2024 player-year...

‘Reconstruction-plus-regeneration-plus-adaptation’: transforming old Tbilisi during and after socialism

Abstract In the late 1970s, the Georgian Soviet Socialist Republic was widely recognised across the socialist world as a leader in urban heritage conservation. Its capital city, Tbilisi, became a showcase of what Chief Architect Shota Kavlashvili defined as a new formula for hist...