Research works

18F-FDG PET/CT-based Metabolic-clinical prognostic model could refine risk stratification in high-risk neuroblastoma

The prognosis of high-risk neuroblastoma (NB) is highly heterogeneous, underscoring the necessity of refining risk stratification to guide precision treatment and improve outcomes. The aim of this study was to construct an 18 F-FDG PET/CT-based Metabolic-clinical prognostic model...

Recombinant Thermostable DNA Polymerases: Current Approaches to Production, Molecular Engineering, and Applications in Biotechnology and Diagnostics

DNA polymerases are crucial for the replication and repair of genetic material. Advances in recombinant DNA technology and protein engineering have enabled the production of enzymes with specific catalytic properties tailored to the requirements of molecular diagnostics, next-gen...

Revisiting the Fragmentation of Ketoconazole by Positive Electrospray Ionization Tandem Mass Spectrometry and Density Functional Theory Calculations

ABSTRACT Rationale Ketoconazole (KCZ) is a clinically essential antifungal and potent CYP3A4 inhibitor. Its gas‐phase fragmentation under positive electrospray ionization tandem mass spectrometry (ESI‐MS/MS) remains poorly characterized, undermining metabolite profiling and struc...

In children requiring emergency vascular access, are intraosseous lines associated with significant long-term complications?

Intraosseous (IO) access is a technique increasingly used within trauma and emergency settings where immediate vascular access is required. It provides an effective alternative to intravenous access, particularly in paediatric patients where intravenous access is difficult, or wh...

Literacy Identity Construction, Negotiation, and Resistance Among Middle School Students of Color in Online Learning

ABSTRACT This qualitative multiple case study examines how middle school Students of Color construct, negotiate, and respond to literacy identities within classroom‐based online learning contexts. Guided by racialized identity development in learning contexts, the study examines...

Rural-Urban Disparities in Contemporary Systemic Therapy for Advanced Prostate Cancer

This cross-sectional study examines the associations of rural-urban residence and race with receipt of systemic therapy for advanced prostate cancer.

CAD2TechSpec: a framework for automating design processes within computer-aided design systems

This article presents CAD2TechSpec, a novel framework for automating design processes within computer-aided design (CAD) systems by leveraging multimodal large language models (LLMs). The framework enables the analysis and generation of detailed design specifications, including t...

Fetal brain five-axial planes and 3D-ICRV cerebral surface imaging from 16 to 36 weeks of gestation

Abstract Background Recent advances in fetal neurosonography have increased interest in prenatal cortical assessment. However, the transvaginal approach, while providing superior resolution, is technically complex and limited to specialized settings. Methods This study utilizes a...

Computational Guided Structural Design for Optimized Pore Size and Shape Metal‐Organic Framework Enabling One‐Step CH 4 and C 3 H 8 Purification From CH 4 /C 2 H 6 /C 3 H 8 Ternary Gas Mixture

ABSTRACT Current natural gas upgrading strategies primarily focus on CH 4 recovery, treating C 2 H 6 and C 3 H 8 merely as impurities, which results in resource wastage. In this work, an advanced industrial operation, simultaneous separation of both pure CH 4 and C 3 H 8 from CH...

Loading-environment coupled prediction of pavement performance based on RIOHTrack data and PSO-XGBoost modeling

This study develops an interpretable pavement performance prediction framework to quantify the coupled effects of loading and environmental factors on rutting and deflection. A high-quality dataset was established through preprocessing. Empirical Mode Decomposition was then used...

The Role of Motivational Instructional Design in Self-Directed Learning and Achievement Motivation in Higher Education

Teaching remains central to higher education, where increasing demands for learner autonomy require instructional approaches that effectively support students’ motivation and engagement. This study examined the relationship between motivational instructional design, based on Kell...

A Scale-Invariant Adaptive Test for IFR Alternatives Based on Cumulative Residual Entropy Under Proportional Hazards

Testing exponentiality against increasing failure rate alternatives is central to reliability theory and lifetime data analysis. This paper develops the Adaptive Cumulative Residual Entropy Test under Proportional Hazards (Adaptive CRE-PH Test), a scale-invariant nonparametric pr...

A Flexible Lifetime Distribution Based on Alpha Power Transformation: Properties, Inference and Data Analysis

The Rayleigh–Logarithmic distribution provides a useful framework for modelling lifetime data by combining continuous lifetime variability with a logarithmic compounding mechanism. This study introduces a three-parameter Alpha Power Rayleigh–Logarithmic (APRL) distribution by app...

2-Ethylhexyl diphenyl phosphate exposure is associated with poorer overall survival in advanced high-grade serous ovarian cancer: Integrated epidemiological and experimental evidence implicating the ITGB1–FAK–AKT axis

Background Organophosphate esters (OPEs) are globally used flame retardants and plasticizers with widespread human exposure. Whether OPE exposure affects survival in advanced high-grade serous ovarian cancer (HGSOC) and the underlying mechanisms remains unclear. We aimed to ident...

An Enhanced Rule-Based Energy Management System with Integrated Route and Environmental Information for Battery–Supercapacitor Hybrid Electric Vehicles

In this paper, a route- and environment-aware rule-based energy management system (EMS) strategy for EVs equipped with HESSs consisting of a lithium-ion battery and a supercapacitor is proposed. The proposed rule-based EMS integrates driving mode classification, traffic condition...

EuroMillions Breakthrough Mining — 1671 Sources, 12208 Leads Extracted — E8 Intelligence Research

Mined 1671 lottery+quantum breakthroughs. Extracted 12208 leads across 13 categories. 10226 high-value leads found. Categories: {"CORRIDOR": 1012, "FORMULA": 856, "GEOMETRIC": 718, "FORWARD_ATTEMPT": 1061, "QUANTUM": 1274, "TIMING": 204, "CELESTIAL": 940, "GEMATRIA": 1008, "CONST...

Precision Greenhouse Rose Phenotyping from UAV Imagery Using a Multi-Source Dataset and Lightweight BloomRoseNet

Accurate detection of blooming roses and flower buds is essential for greenhouse phenotyping, cultivation scheduling, harvest planning, and yield management. However, UAV-derived greenhouse imagery presents major challenges because rose targets are often small, densely distribute...

Comparing experience intensity of AR and VR for contrasting phobia stimuli

Abstract Exposure-based therapy is a common psychological intervention for phobias and anxiety disorders, and exposure-based therapy using virtual reality (VR) and augmented reality (AR) have been evaluated as practical extensions of this method, producing similar experiences thr...

When Medical Management Is Not Enough: A Case Report of Progressive Thyromegaly Secondary to Hashimoto Thyroiditis

A man in his mid-fifties with a more than 30-year history of hypothyroidism secondary to Hashimoto thyroiditis and a strong family history of thyroid disease was referred for a surgical evaluation after developing rapidly progressive thyromegaly associated with anterior neck disc...

Google AI Achieves Quantum Error Correction Below Threshold, Enabling Scalable Logical Qubits — E8 Intelligence Research

FINDING: Quantum error correction (QEC) milestone — Google AI demonstrates error suppression below threshold, enabling scalable logical qubits. | MATH: Key threshold constant: error rate per operation \( p < p_{\text{th}} \approx 0.57\% \) (surface code). Logical error rate scale...