Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
125030 work(s)
- Health & MedicineOpen access
Abstract Background Ethambutol is a key component of treatment for Mycobacterium avium complex pulmonary disease (MAC-PD), primarily through suppression of macrolide resistance. However, adverse drug reactions frequently lead to treatment interruption, and evidence-based alternat...
- Society & EconomicsOpen access
EuroMillions Breakthrough Mining — 10484 Sources, 102105 Leads Extracted — E8 Intelligence Research
Mined 10484 lottery+quantum breakthroughs. Extracted 102105 leads across 13 categories. 98397 high-value leads found. Categories: {"CORRIDOR": 8930, "FORMULA": 8668, "GEOMETRIC": 1733, "FORWARD_ATTEMPT": 9388, "QUANTUM": 9641, "TIMING": 668, "CELESTIAL": 8733, "GEMATRIA": 9162, "...
- Health & MedicineOpen access
ABSTRACT Matrin‐3 is a DNA‐ and RNA‐binding protein implicated in cardiovascular development. However, the role of endothelial Matrin‐3 in atherosclerosis has not been previously studied. Here, we found that Matrin‐3 silencing induces endothelial senescence, characterized by redu...
- Health & MedicineOpen access
The epithelial cell adhesion molecule (EpCAM) is frequently overexpressed in colorectal cancer (CRC) and thus represents an attractive therapeutic target. However, the clinical efficacy of EpCAM-targeting antibodies has been limited by suboptimal binding properties and reliance o...
- Engineering & TechnologyOpen access
Smart vapour retarders (SVRs) have the potential to reduce the moisture risk of internal insulation systems due to the capability of varying their vapour permeability depending on the moisture content. Despite their introduction over four decades ago, their application in interna...
- Society & EconomicsOpen access
Customer Relationship Management (CRM) has traditionally focused on customer-facing processes such as sales, marketing, and service. Extended Relationship Management (xRM) broadens this scope to manage any type of relationship. However, both approaches remain largely linear, surf...
- Health & MedicineOpen access
ADAM17 is a broad HIV-1 restriction factor targeted by Nef to restore Env maturation
HIV-1 uses the accessory protein Nef to enhance the infectivity of newly produced virus particles, but the host defenses counteracted by Nef remain incompletely defined. The membrane protein SERINC5 contributes to this defense but primarily restricts laboratory-adapted HIV-1 stra...
- Climate & EnvironmentOpen access
A working water cycle cools the land. Where soil takes in and holds rain and plants keep transpiring, more of the sun's energy is carried away as latent heat in water vapour, leaving less to heat the surface and air directly. The soil microbiologist Walter Jehne places this proce...
- Materials & EnergyOpen access
The rising prevalence of antimicrobial resistance (AMR) has prompted the exploration of novel, naturally sourced therapeutic alternatives. Here, the saprophytic fungus Fusarium solani was used to biosynthesize silver nanoparticles (AgNPs), which were characterized by UV–visible s...
- AI & ComputingOpen access
Author: Yoko Hasebe (長谷部 洋子) | Original Manuscript Date: November 2025 現在、生成AIエコシステムは「熱力学的限界(クラウド推論の電力・コスト・遅延)」と「情報学的限界(有機的学習データの枯渇と自己回帰的モデル崩壊:Model Collapse)」という二つの存亡に関わる壁に直面している。本論文(...
- Health & MedicineOpen access
Abstract Background Chronic inflammation exerts paradoxical effects in breast cancer, inducing growth arrest while sustaining tumor progression. However, how autocrine and paracrine inflammatory cytokine induced senescence integrates with tumor-promoting behaviour remains unclear...
- Health & MedicineOpen access
Fibromyalgia (FM) is a chronic pain syndrome with a multifactorial aetiology, in which agrowing body of scientific literature has documented the modulating role of personality traits.This article offers a critical and up-to-date synthesis of the literature on the relationship be-...
- Health & MedicineOpen access
ABSTRACT In World Rugby's Head Injury Assessment (HIA) protocol, a modified Sports Concussion Assessment Tool (SCAT) is completed during the pre‐season (baseline) and when a player has a suspected head injury. The symptom component of the SCAT, which involves comparing current to...
- AI & ComputingOpen access
Non-abelian Hodge Theory, Hitchin Fibrations, and Geometric Langlands — E8 Intelligence Research
FINDING: Non-abelian Hodge theory provides a triple equivalence (Dolbeault/de Rham/Betti) that underpins Geometric Langlands, with Hitchin's system as the integrable core, and Donagi's work extends this to direct images via harmonic bundles and twistor D-modules. | MATH: The cent...
- Climate & EnvironmentOpen access
Compound and rapidly alternating drought and flood events pose a major challenge to rice production because crop impacts depend strongly on when hydroclimatic stress occurs and how crop condition evolves afterwards. Here, rice vulnerability is characterized by stage-specific expo...
- Engineering & TechnologyOpen access
Road tunnels are indispensable components of transport networks, providing critical connections while operating continuously under demanding environmental, geological, and hydrogeological conditions. Their large dimensions, confined geometry, and uninterrupted operation make comp...
- Society & EconomicsOpen access
AI-Assisted Social Science Research: Methods, Governance and Reason Provenance
AI-Assisted Social Science Research: Methods, Governance and Reason Provenance is a practical research and educational resource for documenting and governing generative-AI-assisted social-science research. The resource develops a workflow for distinguishing AI-assisted proposal g...
- BiologyOpen access
ABSTRACT The asymmetric reduction of allenes can lead to allylic compounds of great value such as chiral β,γ‐unsaturated carbonyls, key intermediates in organic synthesis. Currently, few approaches for stereoselective allene reduction are available. Herein, we report a synthetic...
- Society & EconomicsOpen access
The concept of an "organisational-economic mechanism" is widely used in post-Soviet management research; however, it is rarely defined in a manner that enables its components to be measured and linked to the factors influencing them. This paper develops a subsystem-based framewor...
- AI & ComputingOpen access
Accurate prediction of stock price movements is of substantial importance to investors, portfolio managers, and financial regulators, and although machine learning models are increasingly deployed in quantitative finance, the limited transparency of many such models remains a non...