Research works

Simultaneous determination and ADME profiling of betulinic and ursolic acids from Avicennia marina in Wistar rats

Avicennia marina (grey mangrove) (AM) is a significant source of bioactive pentacyclic triterpenoids, specifically Betulinic acid (BA) and Ursolic acid (UA). Owing to their therapeutic potential, the pharmacokinetic (PK) profiles of these bioactives after administration of AM ext...

Association between adherence patterns to antifibrotic therapy and survival in fibrotic interstitial lung disease: a nationwide Austrian health claims study

Antifibrotic therapies slow disease progression in patients with progressive fibrosing interstitial lung diseases (PF-ILD). However, long-term adherence is difficult to maintain mainly due to side effects. Real-world data on adherence and its association with prognosis are still...

Targeting CD38 Across Autoimmune and Plasma Cell–Driven Immune-Mediated Diseases: Rationale, Clinical Evidence, and Emerging Therapeutic Landscape

Autoimmune diseases remain a major cause of chronic morbidity despite substantial advances in targeted immunomodulatory therapies. In many autoantibody-mediated conditions, disease refractoriness and relapse are driven by long-lived plasma cells, which are largely resistant to co...

The relationship between the uric acid to prealbumin ratio and frailty, muscle strength, and malnutrition risk in older geriatric outpatients: a retrospective cross-sectional study

Frailty, sarcopenia, and malnutrition are common in older adults; however, simple biomarkers reflecting both inflammatory and nutritional status remain limited. We aimed to evaluate the relationship between the uric acid-to-prealbumin ratio (UPR) and frailty, muscle strength, and...

Multimedia fate and transport simulation for green synthesized zero valent iron nanoparticles using SimpleBox4nano

Green synthesized zero valent iron nanoparticles (nZVI) are promoted as environmentally benign alternatives to chemically synthesized ones. Simulation models are used to predict nZVI transport and transformation during environmental remediation. The objective of this study was to...

Comparison of estimated personalized treatment rules under varying interference structures and treatment rates using dynamic weighted ordinary least squares

Dynamic treatment regimes (DTRs) are statistical methods that use patient-specific information to estimate an optimal sequence of treatments, with the end goal of maximizing a desired outcome of interest. DTRs have many useful applications to chronic disease management when patie...

Atypical CTPA contrast timing revealing a suspected right-to-left shunt in a patient with advanced COPD and concurrent pulmonary malignancy

Hypoxemia in chronic obstructive pulmonary disease (COPD) typically arises from ventilation-perfusion (V/Q) mismatch. However, refractory hypoxemia should raise concern for alternative mechanisms, such as intracardiac shunting. This report describes a rare presentation where a ca...

Clinical Utility of a Type 1 Diabetes Genetic Risk Score Measured as Part of MODY Genetic Testing

<p dir="ltr">Objective</p><p dir="ltr">To evaluate the clinical utility of incorporating a type 1 diabetes genetic risk score (T1DGRS) into monogenic diabetes gene panel testing for individuals referred with suspected maturity-onset diabetes of the young (MODY)...

Ultrasound-guided stellate ganglion block enhances hemodynamic stability and postoperative recovery after laparoscopic myomectomy: a randomized controlled trial

To evaluate the effects of ultrasound-guided right stellate ganglion block (SGB) combined with propofol-based general anesthesia on perioperative hemodynamics, postoperative pain, recovery, and inflammatory stress responses in women undergoing laparoscopic myomectomy. In this sin...

A multilevel analysis of the predictive effects of internal migration and region of residence on women’s empowerment in Nigeria

BACKGROUND: Despite growing research interest on the influences of migration and regions of residence on human behaviors, studies on the influences of migration and region of residence on women empowerment especially in sub-Saharan Africa are lacking. Thus, this study investigate...

Cell-based Therapies in Acute Lymphoblastic Leukemia Treatment: Current Advancements and Limitations

Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by clonal expansion of immature lymphoid precursors in the bone marrow and extramedullary sites. Although frontline chemotherapy induces remission in most patients, relapse, treatment resistance, and cum...

Road traffic injuries among older adults before and after a major earthquake: a single-center retrospective study

Road traffic injuries are a major cause of morbidity and mortality among older adults, frequently leading to prolonged hospitalization, functional decline, and loss of independence. Large-scale disasters, such as earthquakes, may act as important modifiers of mobility patterns an...

SNCA-targeted transcriptional repression therapy alleviates pathological and behavioral perturbations in a Parkinson's disease mouse model

Alpha-synuclein (SNCA) overexpression is implicated in Parkinson's disease (PD) pathogenesis, making SNCA downregulation a promising therapeutic strategy. We developed a SNCA -targeted transcriptional repression therapy using an all-in-one lentiviral vector (LV) carrying deactiva...

From international experience to global mindset: The contingent role of organizational context

Global mindset is widely recognized as essential for navigating cultural diversity and strategic complexity in multinational enterprises (MNEs). While prior research has identified individual factors influencing its development, less is known about how individual and organization...

Multi-omics analysis identifies the super-enhancer-driven gene NPW in left-sided obstructive lesions-associated cardiac remodeling

Left-sided obstructive lesions (LSOLs), represented by coarctation of the aorta (CoA), cause persistent vascular pathology and pressure overload that can lead to pathological cardiac remodeling. However, the epigenetic changes associated with local vascular abnormalities and vent...

Homogenizer-assisted dispersive liquid-liquid microextraction followed by ion mobility spectrometry for the fluconazole determination in real samples

This study developed a new method based on homogenizer-assisted dispersive liquid-liquid microextraction (HA-DLLME) followed by ion mobility spectrometry (IMS) for determining fluconazole in different samples. A homogenizer was used to disperse the extraction solvent, which has t...

Long-term outcomes of hemithyroidectomy in unexpected hereditary medullary thyroid cancer: a nationwide observational study

Total thyroidectomy (TT) is the standard surgical approach for hereditary medullary thyroid cancer (hMTC). However, it is not rare in clinical practice for patients with hMTC to initially undergo hemithyroidectomy (HT) because the hereditary nature of the disease is not recognize...

Optimal strategies for pancreatic stump management in distal pancreatectomy: A network meta-analysis of randomized controlled trials

Postoperative pancreatic fistula (POPF) is the most common and clinically significant complication following distal pancreatectomy (DP). Despite numerous randomized trials evaluating stump closure and reinforcement techniques, the optimal strategy remains uncertain. We conducted...

A multicohort, biomarker-driven phase 2 trial of personalized total neoadjuvant therapy with targeted agents for high-risk rectal cancer (The TRAINER study)

This multicohort, single-center, phase II trial explored the efficacy and safety of a biomarker-driven total neoadjuvant therapy (TNT) regimen in high-risk locally advanced rectal cancer (LARC) patients. The regimen included induction chemotherapy (4 cycles of mFOLFOX6) with targ...

Adult lupus anticoagulant hypoprothrombinemia syndrome with combined factor II and X deficiencies: diagnostic and therapeutic challenges

Background: Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare, acquired coagulopathy characterized by the presence of lupus anticoagulant and deficiency of factor II, causing paradoxical bleeding despite prothrombotic antibodies. LAHPS may cause falsely low INR v...