Research works

Legitimacy Signals and Investor Protections: Top-Tier Law Firms in Global Venture Capital Investments

Venture capital (VC) transactions are impeded by two frictions: entrepreneurs cannot credibly signal quality to investors, and investors cannot fully protect themselves against governance risks in incomplete–contract relationships. We argue that top-tier law firms address both fr...

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

ABSTRACT Immune surveillance hinges on the precise regulation of molecular sentinels to maintain the equilibrium between physiological homeostasis and pathological distress. Central to this process is the sensing of exogenous pathogen‐associated molecular patterns (PAMPs) and end...

Intensity–complexity post-triage prioritization to shorten waiting times in emergency departments

Abstract Emergency department triage reliably identifies patients at immediate risk, although it compresses heterogeneous clinical profiles into a small number of urgency categories, leaving discretion in how patients are prioritized within the same category. We propose a second-...

Toward a Substrate-Independent Mechanics of Information and Equilibrium

This seminal BRPT paper boldly redefines the landscape of scientific inquiry, presenting a groundbreaking framework for substrate-independent mechanics of information and equilibrium. It meticulously dismantles the artificial boundaries imposed by ‘Cold Logic’ taxonomic systems,...

Evaluation of an institutional leadership program’s impact on skills and confidence

The Career Development for Women Leaders (CDWL) program was developed to enhance leadership skills for mid- and senior-career faculty through monthly sessions addressing leadership topics. Participants completed pre-, post-, and two-year follow-up program surveys, using items fro...

The Dewhirst Horizon Relation: Resolving the Hubble Tension and Recalculating Cosmic Expansion Timelines

This cosmological research paper applies the Dewhirst Horizon Relation—a theoretical framework formulated by Richard Stephen Dewhirst that replaces the static speed of light squared constant (c²) with a dynamic macro-to-micro spacetime horizon ratio—to resolve the Hubble Tension...

P1.225. The Impact of Metformin Use During Neoadjuvant Chemoradiotherapy in Esophageal Cancer Patients: A Propensity Score-Matched Nationwide Study

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Our previous study suggested an association between metformin use and complete response rates in esophageal cancer patients undergoing neoadjuvant concurrent chemoradiotherap...

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

P1.086. Impact of Surgery Versus Non-Surgery on the Prognosis of Esophageal Cancer Patients With Clinically Identified Metastatic Supraclavicular Lymph Nodes

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background The clinical significance of supraclavicular lymph node (SCLN) involvement in esophageal cancer remains controversial. The role of surgery in managing patients with SCLN metastases remains uncertain....

Microbial modulation of secondary metabolites biosynthesis in plants

Abstract Plants produce a diverse range of secondary metabolites [SMs] such as alkaloids, terpenoids and phenolics, which play crucial roles in defense, signalling and human health applications like pharmaceuticals and nutraceuticals. Traditionally viewed as autonomous plant bios...

Financial Education and Loan Default Behaviour in Rural Microfinance Systems: Evidence from Structural Equation Modelling in Cameroon

Abstract The biggest operational threat to microfinance institutions is likely the absence of financial education for MFI clients. This study attempts to investigate the effect of financial education of MFIs' clients on the rate of loan default. The study employed an opportunisti...

A Dual-Component Nurse Practitioner Intervention to Improve Symptom Management for Caregivers of Persons Living With Dementia

The number of patients living with dementia (PLWD) has steadily increased, making it the fifth leading cause of death among adults. While hospice care is standard for end-of-life symptom management, predicting 6-month survival is challenging, leaving many who could benefit inelig...

Optical-thermal modeling and treatment planning of ICG-enhanced interstitial photothermal therapy using cylindrical diffuser fibers

Interstitial photothermal therapy (IPTT) enhanced with indocyanine green (ICG) represents a minimally invasive approach with growing interest for localized thermal ablation of deep-seated tumors. In this work, an optical–thermal modeling framework is developed to investigate heat...

Phi-Resonant E8 Topological Phase via 132 Hz Harmonic Lattice Compression — E8 Intelligence Research

By arranging the 240 E8 root vectors into a 4‑dimensional hyperlattice and modulating it with a phi‑scaled 132 Hz harmonic driver, the system self‑organizes into a quasiperiodic Penrose‑type tiling of Berry curvature. This emergent topology supports protected edge states whose ph...

P1.033. DAM (Dual Anchored Mesh) Intercrural Technique for Hiatal Hernia Repair: Case Series Aiming to Reduce Complications and Recurrence

Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Hiatal hernia repair with mesh reinforcement remains controversial due to recurrence and mesh-related complications. We present a descriptive case series introducing a laparoscopic intrahiatal in...

Accounting for the Expansion of the Universe Using an Energy/Momentum Model to Construct the Space-time Metric

Background The success of the theories of special and general relativity in describing localised phenomena, such as objects undergoing high speed motion or located in gravitational fields, needs no further elaboration. However, when applied to the evolution of the universe severa...

Making Regeneration Observable: A Longitudinal Multimodal Perturbation-Response Framework for Distraction Osteogenesis

Distraction osteogenesis (DO) is a uniquely observable form of tissue regeneration: an osteotomy is followed by latency, repeated mechanical distraction, and consolidation, while the patient remains within an accessible treatment construct for months. Yet monitoring remains domin...

P1.215. Segmental Loss of Signal on Continuous Intraoperative Nerve Monitoring Predicts Postoperative Pneumonia After Transmediastinal Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Recurrent laryngeal nerve paralysis (RLNP) is a well-known risk factor for postoperative pneumonia in esophageal cancer surgery. Transmediastinal esophagectomy,...

The first RNAi ‐based biopesticide approved in the United States: regulatory implications for the European Union – the case of Ledprona (Calantha™)

Abstract RNA interference (RNAi), a naturally occurring gene‐silencing mechanism, has emerged as a promising platform for developing innovative, non‐genetically modified (GM) plant protection products. In the context of climate change, biodiversity loss, and growing resistance to...

The Spectral Ledger

Abstract We present a unified framework for the Riemann zeta function ζ(s), organized around three interlocking programmes and closed by a spectral-computing application layer. Part I (Uniqueness) establishes the Framework Uniqueness Theorem chain: the Davenport–Heilbronn counter...