Research works

Harmonic Maps on the Bloch Ball with the Bures Metric: Local Jets, the Global \(S^{3}\) Spectrum, and the Distortion Observable \(D, Q\)

This repository contains the complete replication package for the research paper: "Harmonic Maps on the Bloch Ball with the Bures Metric: Local Jets, the Global $S^3$ Spectrum, and the Distortion Observable $D, Q$". We study harmonic self-maps $\Phi : \mathcal{M} \to \mathcal{M}$...

Comparison of lumbar interbody fusion with PEEK cage, titanium-coated PEEK cage and 3D-printed porous titanium cage for the treatment of lumbar degenerative disease: a systematic review and network meta-analysis

Abstract Background As two classic representative materials, solid titanium cages and uncoated PEEK cage (UPC) each have distinct inherent advantages and limitations, and 3D-printed porous titanium cage (3DPPTC) and titanium-coated PEEK cage (TCPC) have been increasingly applied...

A Stability Refinement of Shearer's Bound for Triangle-Free Graphs

We begin by briefly exploring a restricted graph family of triangle free graphs to establish a baseline to work the rest of the paper off. We then develop a quantitative lower bound on the discrete curvature of Shearer's bound, yielding a stability refinement. In the Ramsey-scale...

Icariin: Unraveling Ferroptosis Mechanisms, Metabolic Networks, and Innovative Therapy Strategies

Ferroptosis is an iron-dependent form of cell death driven by lipid peroxidation. This concept reshapes our understanding of tissue degenerative lesions and oncogenesis. Icariin (ICA) is an isoprenyl flavonol glycoside derived from plants of the genus Epimedium. Acting as a bidir...

Tribochemical and tribomechanical effect of TiO 2 nanoparticle: Different influence on MoDTC and ZDDP additives

Abstract This study investigates the formulation-dependent tribochemical regulation of TiO2 nanoparticles in molybdenum dithiocarbamate (MoDTC), zinc dialkyldithiophosphate (ZDDP), and their blended lubricant systems. Reciprocating ball-on-disk tribological tests were conducted u...

Bisection Regression Trees: Recursive Binary Classification Cascades for Continuous Prediction

We present Bisection Regression Trees (BRT), a regression method that recursively partitions the target’s value space rather than its feature space. At every node, BRT asks a single binary question, is the target above or below the median value currently observed, delegates the a...

Community-Based Nursing Interventions, Discharge Planning and Hospital Readmissions in Nyandeni Local Municipality, Eastern Cape, South Africa

Background Chronic diseases place a substantial pressure on healthcare systems, particularly in resource-constrained rural settings. Community-based nursing interventions and effective discharge planning are recognised as key strategies for improving continuity of care and reduci...

The Dewhirst Horizon Relation: Resolving the Quantum Measurement Problem and Modifying Schrödinger's Wave Mechanics via Horizon Operators

This paper integrates the scale-invariant properties of the Dewhirst Horizon Relation—a physical framework formulated by Richard Stephen Dewhirst that replaces the static speed of light squared constant (c²) with a dynamic macro-to-micro spacetime horizon ratio (\(\Omega _{D}\))—...

SLEEP AND CIRCADIAN RHYTHMS IN RELATION TO ANDROGEN STATUS IN MIDDLE-AGED MEN: CURRENT EVIDENCE AND CLINICAL IMPLICATIONS

Testosterone secretion in men exhibits pronounced temporal variation and is closely associated with the sleep–wake cycle. Short sleep duration, sleep fragmentation, obstructive sleep apnea, night-shift work, and circadian misalignment are common in modern populations and may inte...

Evaluation of nuclear abnormalities in buccal mucosa cells of grazing cattle from pastures routinely treated with 2,4-D: an exploratory field study

The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used in agricultural systems, raising concerns about its potential genotoxic effects on non-target organisms. This cross-sectional observational field study evaluated nuclear abnormalities in exfoliated buccal mucosa...

Targeting the Thy-1 mechanotransduction regulator rescues regenerative wound healing and induces hair follicle neogenesis under high tension

Abstract Mechanical tension is a critical driver of hypertrophic scar (HS) formation, primarily by inducing the differentiation of fibroblasts into pathological myofibroblasts. However, the upstream mechanotransduction regulators that initiate this fibrotic cell fate switch remai...

Distinct regulation of Wnt signaling and EPZ5676 governs human UiPSM reprogramming via the CDX2/T/TBX6 core axis

An ideal in vitro system to study somitogenesis is induced presomitic mesoderm (UiPSM); the regulatory pathways of this system are not well understood. Here, integrated multi-omic and functional analyses were performed to elucidate the roles of Wnt signaling and EPZ5676 in UiPSM...

Perceived academic disruption in the event of a future pandemic among Latin American university students: a multicountry cross-sectional study

Abstract Introduction The COVID-19 pandemic substantially disrupted higher education by limiting in-person training and accelerating the transition to virtual learning. During the 2022 mpox outbreak, concerns emerged about the possibility of renewed academic disruption among univ...

Broken Input Looks Exactly Like Bad Reasoning

When a language model pipeline produces a wrong judgment, the field's default diagnosis is that the model reasoned badly. This paper documents four cases from a production legal citation verification system where that diagnosis would have been wrong. In each, the model reasoned c...

Graph-based AI approaches for supply chain risk and fraud detection

Supply Chain Risk Management (SCRM) seeks to identify, assess, and mitigate risks such as fraud, operational delays, and financial irregularities to enhance supply chain resilience. This study introduces an Adversarial Autoencoder-based Heterogeneous Graph Neural Network (AAHGNN)...

Communication Accommodation Between Nurses and Patients at a Private Tertiary Hospital: A Protocol Paper

Effective communication between nurses and patients is essential for delivering safe and high-quality healthcare. In Malaysia, although English is the official working language in many private hospitals, many nurses are more comfortable using Malay. This often creates communicati...

The Dewhirst Horizon Relation: Evaluating Blackbody Radiation Anomalies and Stefan-Boltzmann Constancy under the Scale-Invariant Dewhirst Operator

This specialized research paper integrates the scale-invariant properties of the Dewhirst Horizon Relation—a unified physical framework formulated by Richard Stephen Dewhirst that replaces the traditional static speed of light squared constant (c²) with a dynamic, epoch-dependent...

The Carlo Hybrid Hatred Field - A Formal Mapping of Negative Curvature, Cognitive Repulsion, and Emotional Collapse Dynamics

This work presents the full Carlo Hybrid formalisation of hatred as a counter‑rotating emotional attractor with negative curvature and hyperbolic cognitive geometry. Hatred is modelled not as a single emotion but as a recursive operator pipeline driven by expectation collapse, ru...

Alisol A 23,24-diacetate improves LPS-induced acute lung injury through the IL-17A/NF-κB signaling pathway

Abstract Objective This study utilized the multi-model validation method to confirm that Alisol A 23,24-diacetate (AAD) can improve LPS-induced acute lung injury (ALI) through the IL-17A/NF-κB signaling pathway, providing experimental data support for preclinical research. Method...

Harms associated with engaging with AI for mental health support: A scoping review protocol

Background Artificial intelligence (AI) is increasingly used for mental health support, through both purpose-built products and general-purpose large language models (LLMs), at a pace far greater than evidence of their efficacy or safety. There is no consensus taxonomy of the pot...