Research works

The association of physical activity with intrinsic capacity: findings from longitudinal analysis in CHARLS and HRS

Abstract Background Physical activity (PA) is a pivotal modifiable determinant of intrinsic capacity (IC), a core component of healthy aging. Aims This study aimed to examine the association between PA and the risk of IC impairment among middle-aged and older adults using nationa...

Ligand-Induced Stability Studies at the TSH Receptor Show the Linking Region to be a Chameleon

Glycoprotein hormone receptors (GPHRs) share a conserved architecture but the thyroid-stimulating hormone receptor (TSHR) is unique in possessing a large 141-amino-acid region called the hinge or linking region (LR) that contains a 50-amino-acid post translational cleavage site....

Geometry‐Controlled Cooperativity at Binuclear Fe 2 –N 6 Sites Enables Selective Fe IV ═OGeneration for Durable Fenton‐Like Oxidation

ABSTRACT Single atom catalysts (SACs) are emerging as a promising platform for Fenton‐like water purification; however, their practical deployment is often constrained by the trade‐off between high intrinsic activity and long‐term stability. Here, we construct an N‐bridged binucl...

The Structural Decoupling of Algorithmic Distribution and Intrinsic Value: Re-Framing Authentic Authenticity in the Dopamine Economy

Modern digital ecosystems are increasingly governed by engagement-maximizing recommendation algorithms thatreward emotional provocation, high-frequency repetition, and dopamine-driven retention mechanics. Consequently,commercial marketing has experienced a structural decoupling:...

The Catalogue Is the Instrument: how the choice of sign inventory moves the statistics of an undeciphered script

Statistical arguments about undeciphered scripts — whether a sign system "behaves like language" — are computed on a transliteration, and a transliteration presupposes a catalogue of signs. For rongorongo the published catalogues disagree by an order of magnitude, from about fift...

Activity and participation after transient ischemic attack: a scoping review

Transient ischemic attack (TIA) is traditionally regarded as a condition with full recovery. However, emerging evidence suggests that some individuals experience residual symptoms, limiting their activity and participation in everyday life. The objective was to systematically map...

Use of Oxygen in the Emergency Department

ABSTRACT Oxygen is one of the most frequently used treatments in the emergency department (ED), but it should be prescribed and reassessed as an active therapy rather than left as a harmless default. Acute hypoxemia may reflect ventilation-perfusion mismatch, shunt, hypoventilati...

Bertholletia excelsa Shell–Based Wood–Plastic with Upcycled Polypropylene: An Amazonian Feedstock for Circular Bioeconomy Applications

Environmental accumulation issues arise from discarded waste, synthetic, and natural polymers in landfills, whose slow degradation exacerbates the problem. These materials can be upcycled as renewable feedstocks and properly reused. Therefore, this research examines the fabricati...

Institutional compression in climate policy integration: coordinating green electricity certificates and carbon emissions trading in China

Coordinating market-based climate instruments is a central challenge for climate policy, yet the institutional mechanisms through which centralized governance systems pursue such integration remain insufficiently understood. This study examines how China coordinates Green Electri...

90 Developing Patient-Focused Outcomes for Routine Clinical Care in Glioma: A Synthesis of Qualitative Evidence from the COMBaT Study

Abstract Introduction There is a critical need to identify and routinely measure the outcomes that matter most to people living with glioma. Care needs in this population are complex and variable, yet current clinical practice lacks consistent, systematic approaches to assessing...

Artificial intelligence in social work practice for children and youth: A scoping review

Abstract Despite artificial intelligence's (AI) established use in healthcare, its application in social work remains nascent. Therefore, this scoping review examines AI's applications, outcomes or perceived effects, and challenges in social work practice for children and youth,...

How does knowledge integration translate digital technologies into new quality productivity?

Purpose This study aims to explore how and whether digital technology (DT) is positively associated with the development of New Quality Productivity (NP) in carbon-intensive enterprises. Design/methodology/approach Grounded in the Knowledge-Based View (KBV), this paper uses panel...

Targeting SUV4–20H2-mediated H4K20 methylation restrains growth and migration in pediatric high-grade astrocytomas

Pediatric astrocytomas are characterized by increased molecular and clinical heterogeneity with epigenetic alterations contributing to aggressiveness and therapy resistance. The repressive histone mark H4K20 trimethylation (H4K20me3) and the methyltransferase SUV4–20H2 (KMT5C) ar...

Policy and temperature associations with gas-specific G7 transport emissions: Temporal predictability and geographic transportability

This repository contains the processed datasets, metadata, analysis code, and replication materials for the study “Policy and temperature associations with gas-specific G7 transport emissions: Temporal predictability and geographic transportability.” The study examines annual tra...

Nurses’ Ethical Reasoning About Digital Ethical Risks: A Vignette‐Elicited Qualitative Study

AIM: This qualitative study aimed to explore how nurses reason ethically about potential digital ethical risks arising from the routine use of digital systems in clinical practice and the strategies they propose to address these risks in response to vignette-based scenarios. BACK...

Implementing collaborative learning platforms for healthcare quality improvement in Lao PDR: a case study of national forums

Abstract Background Healthcare quality and safety initiatives in low- and middle-income countries often face fragmentation due to varying stakeholders’ readiness levels. Collective learning facilitates knowledge exchange and institutional capacity building, which are crucial for...

LITOTE & HYPERBOLE — Notes méthodologiques complémentaires : Calibration temporelle, présentation de soi et observation de la réception

Ces notes méthodologiques complètent les trois articles consacrés à Litote & Hyperbole, projet de recherche-création développé depuis 2008. Elles précisent trois questions apparues lors de la reprise réflexive du corpus : le statut de la calibration des captations en fragments co...

THE COHERENCE METRIC - A Purely Topological Derivation of Scale Invariant Spacetime Constant via Dural-Fractal Coherence Modulation

This paper introduces the Coherence Metric, a novel dural-fractal spacetime framework that provides a purely topological derivation of fundamental physical constants and cosmic boundaries, fulfilling Hermann Weyl’s 1918 vision of scale invariance. By nesting an orthogonal square...

EuroMillions Breakthrough Mining — 2933 Sources, 24904 Leads Extracted — E8 Intelligence Research

Mined 2933 lottery+quantum breakthroughs. Extracted 24904 leads across 13 categories. 22607 high-value leads found. Categories: {"CORRIDOR": 2112, "FORMULA": 1947, "GEOMETRIC": 881, "FORWARD_ATTEMPT": 2242, "QUANTUM": 2455, "TIMING": 268, "CELESTIAL": 2034, "GEMATRIA": 2141, "CON...

Differential regulation of the proliferative and autophagic responses in murine and human pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) cells rely on autophagy to adapt to microenvironmental stress. In our recent work, we showed that baseline autophagy flux levels shape the proliferative capacity of human PDAC cells. Here, we extend these findings by demonstrating that low...