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Anti-gicerin Antibody Suppresses Early Pulmonary Metastatic Colonization of B16F10 Melanoma Cells

Background/Aim: Adhesion of circulating melanoma cells to the pulmonary vascular bed is a critical early step in hematogenous metastasis. Gicerin is an immunoglobulin superfamily cell adhesion molecule that can mediate homophilic cell-cell adhesion. We examined whether gicerin is...

“Smelltronics”—From Gas to Smell Sensing

This review discusses recent trends in smell and odor-sensing studies, including materials, devices, and interfaces. Since the invention of chemical sensors, particularly over the past few decades, gas sensor materials and devices for small molecules have been extensively investi...

Pain and Analgesic Doses Versus Free Interleukin 18 (IL-18F) Blood Levels Following Surgery: A Prospective Randomized Study of Patients With Minilaparotomy Cholecystectomy Versus Laparoscopic Cholecystectomy

Background/Aim: Cytokines (CYT) are regulators of the acute phase immune response (APR) to inflammation and trauma. The purpose of this work was to assess blood level correlations of various CYTs; interleukin-18 (IL-18), IL-18 binding protein (IL-18BP), free interleukin 18 (IL-18...

The Akunin project: the mysteries and histories of Russia’s bestselling author

The Akunin Project is the first scholarly attempt in English at evaluating the complex and engaging phenomenon of the bestselling contemporary Russian author Grigorii Chkhartishvili, better known u...

EuroMillions Breakthrough Mining — 3017 Sources, 25743 Leads Extracted — E8 Intelligence Research

Mined 3017 lottery+quantum breakthroughs. Extracted 25743 leads across 13 categories. 23443 high-value leads found. Categories: {"CORRIDOR": 2184, "FORMULA": 2018, "GEOMETRIC": 895, "FORWARD_ATTEMPT": 2318, "QUANTUM": 2533, "TIMING": 273, "CELESTIAL": 2104, "GEMATRIA": 2216, "CON...

EuroMillions Breakthrough Mining — 2996 Sources, 25530 Leads Extracted — E8 Intelligence Research

Mined 2996 lottery+quantum breakthroughs. Extracted 25530 leads across 13 categories. 23230 high-value leads found. Categories: {"CORRIDOR": 2166, "FORMULA": 2000, "GEOMETRIC": 892, "FORWARD_ATTEMPT": 2298, "QUANTUM": 2513, "TIMING": 272, "CELESTIAL": 2086, "GEMATRIA": 2196, "CON...

Extended Follow-Up of Botensilimab Plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer Without Active Liver Metastases

PURPOSE: Microsatellite-stable metastatic colorectal cancer (MSS mCRC) has limited treatment options and responds poorly to conventional immunotherapy. We report extended follow-up results from a fully-enrolled, phase 1b cohort evaluating botensilimab (BOT; Fc-enhanced anti-CTLA-...

Enantiomer-dependent biodistribution and exposure determine the in vivo behavior of a pleurocidin-derived antimicrobial peptide

ABSTRACT Antimicrobial peptides (AMPs) display rapid bactericidal activity in vitro , but have largely failed as systemically administered therapeutics, indicating that intrinsic potency alone does not predict in vivo efficacy. Here, we examine how pharmacokinetics, stereochemist...

Traditional Chinese medicine monotherapy in extensive-stage small cell lung cancer

Rationale: Small cell lung cancer (SCLC) is a highly aggressive malignancy. It typically advances quickly, spreads distantly at an early stage, and carries a dismal prognosis, factors that collectively present formidable obstacles to effective treatment. To date, evidence regardi...

Butter-Fat

Volume 36 Number 12 March 1959

Deaf Gain and Spiritual Freakery: Juan González Arintero's Mystical (R)evolution

Abstract: This essay examines the life and thought of Juan González Arintero (1860–1928), Dominican theologian and Servant of God, through the lens of Disability Studies. Best known for restoring mystical theology in the early twentieth century and for advancing a universal call...

Recipient-driven and donor-driven determinants of delayed graft function in paired kidney transplantation: evidence from a Chinese cohort

Background Delayed graft function (DGF) is a frequent complication of kidney transplantations. When both kidneys from a single deceased donor are transplanted into two recipients, DGF outcomes may be discordant, affecting only one recipient, or concordant, affecting both recipien...

Fatal toxic epidermal necrolysis induced by high-dose methotrexate in T-cell acute lymphoblastic leukemia

IntroductionHigh-dose methotrexate (HD-MTX) is a cornerstone in the treatment of acute lymphoblastic leukemia but carries a risk of severe toxicity. Toxic epidermal necrolysis (TEN) is a rare life-threatening adverse reaction.Case reportWe report the case of a 15-year-old male wi...

Babylonian Base-60: Optimal Arithmetic via Highly Composite Numbers and Icosahedral Symmetry — E8 Intelligence Research

FINDING: The sexagesimal system (base-60) of ancient Babylonians is mathematically optimal due to 60 being a highly composite number, and this connects to crystallographic symmetry through the A2 root lattice (hexagonal tiling) and icosahedral symmetry (which contains 60 rotation...

Application of Genomics to Prevent and Combat Emerging Infectious Disease Threats in Latin America: Perspectives from an Overseas U.S. Navy Research Command

Endemic and (re)emerging infectious diseases pose a major threat to public health and military readiness in Central and South America. The high biodiversity and the differing transmission pathways require the use of highly sensitive methods to track the emergence and spread of th...

Virtual reconstruction beyond the past: heritage future-making at the Capuchos convent in Alferrara, Portugal

While virtual reconstruction commonly aims to visualise the past, this article argues that its knowledge production can also contribute to heritage future-making. We explore this in the ruins of the Capuchos Convent in Alferrara, Portugal, a largely forgotten site founded by Fran...

Laccase‐induced structural remodeling of cottonseed protein for improving its emulsion stability and curcumin bioaccessibility

BACKGROUND: Cottonseed is an important byproduct of cottonseed processing and is rich in proteins. A literature review indicated that cottonseed protein isolate (CPI) demonstrated a compact structure because of its limited exposure of hydrophobic groups, leading to poor emulsifyi...

Navigating accountability: How Russian English-speaking media framed the 2014 sanctions and the Skripal case

This article explores how Russian English-speaking media, Russia Today and Sputniknews, framed the roles of the West on one side and Russia on the other in the case of the imposition of Western sanctions against Russia in 2014, reacting to the outbreak of conflict in eastern Ukra...

Minimal organism JCVI-syn3.0, an engineered derivative of Mycoplasma mycoides , encodes an assortment of unrecognized membrane transporters and immunity factors

ABSTRACT In 2016, researchers at the J. Craig Venter Institute produced JCVI-Syn3.0, a derivative of Mycoplasma mycoides subsp. capri Large Colony strain GM12 with a re-engineered, minimized genome. The minimal synthetic genome of 532 kbp encodes 473 genes, selected from ∼910 par...

Using the Diffusion of Innovations Theory to Explore U.S. Horticultural Industry Stakeholders’ Adoption of Alternative Substrates

Peat is commonly used in container substrates; however, concerns about reliance on imported products, inconsistent availability, and environmental sustainability are increasing growers’ interest in transitioning to alternative soilless substrates. Several studies have explored gr...