Research works

Latent Meta-Abstraction over Transformer Representations: A Two-System Architecture for Persistent Meta-Abstraction and Compute Leverage

This concept paper proposes a two-system architecture pairing a conventional transformer (Primary Model) with a separately parameterized Meta-Abstraction Model restricted operationally to activation-derived Primary representations and its own latent memory. A smaller or lower-cos...

A systematic review of machine learning and explainable artificial intelligence for electrocardiogram based cardiovascular disease prediction

Cardiovascular disease (CVD) are a leading cause of global morbidity and mortality, making early and accurate detection essential for improving patient outcomes. The electrocardiogram (ECG) is one of the most important diagnostic tools for identifying various cardiac abnormalitie...

Ai-Dependent Judgment - How AI Reshapes the Formation and Transfer of Judgment

This paper examines how artificial intelligence changes the formation of judgment inside institutions even when formal decision authority resides with humans. It distinguishes between AI-supported, AI-influenced and AI-shaped judgment, and traces how AI can alter framing, evidenc...

Redefining Secondary Immunodeficiency: a Systematic Review of Therapy-Driven Risk, Functional Immune Deficits, Diagnostic Inconsistencies, and Global Gaps in Standardized Care

Secondary immunodeficiency is an acquired immune deficiency caused by various factors, including cancer treatment, organ failure, chronic disease, nutritional deficiency, and physiological aging. It impairs antibody production, attenuates T-cell immune function, disrupts mucosal...

Autism and attention-deficit/hyperactivity disorder traits as predictors of tic phenomenology in children and adolescents

Abstract The co-existence of autism and attention deficit/hyperactivity disorder in tic disorders is a key factor influencing clinical decision-making. Given the shared clinical features and a potentially overlapping aetiology, the need to identify specific tic characteristics as...

Resolving the Cosmological Constant Problem via Dual-Scale Geometric Holography

The most severe discrepancy in modern theoretical physics is the vacuum catastrophe—a staggering $10^{120}$ order-of-magnitude gap between the vacuum zero-point energy density calculated by classical quantum field theory and the dark energy density observed astronomically. Based...

Prevalence of virulence-associated genes in culture-confirmed Vibrio cholerae isolates: a PCR-based study

Vibrio cholerae remains a major cause of cholera outbreaks in Ethiopia, yet information on the distribution of virulence-associated genes among circulating strains is limited. This study aimed to detect major virulence genes in culture-confirmed V. cholerae isolates recovered fro...

Hydra-Flux – Operational Addendum (Variant B: Layered / Stratified Systems)

Conventional offshore production tests in unconsolidated marine gas hydrate reservoirs—specifically within Archetype B (Layered/Stratified Sands)—frequently encounter critical hydraulic conformance failures due to fluid bypass and severe geomechanical instability leading to wellb...

Hallux Valgus, Not Hallux Abductus Valgus: A Short Report on Historical and Anatomical Terminology

Background: This short report argues that the term “hallux abductus valgus” is anatomically inconsistent and should be replaced by “hallux valgus.” Hallux valgus describes a lateral deviation of the great toe with a medial deviation of the first metatarsal. Although the deformity...

Prevalence and inter-relationship of depressive symptoms, anxiety symptoms and poor sleep quality and their associations with quality of life in patients with coronary heart disease: findings from a large nationwide survey

Patients with coronary heart disease (CHD) commonly experience depressive and anxiety symptoms, poor sleep quality, and low health-related quality of life (HRQoL). However, inter-relationships between such mental health problems at a symptom level and their associations with HRQo...

Deep seeding resistance in maize: selected after domestication or a strategy of its wild ancestors to escape underground animal burrowing?

Abstract Buried seeds avoid predation ensuring their survival until conditions are suitable for germination. The ability of seedlings to emerge from the soil depends on soil characteristics, burial depth, and the skotomorphogenic program of each species. This process is of intere...

ISOLATION AND MOLECULAR IDENTIFICATION OF SOIL-DERIVED FUNGI WITH AROMA-PRODUCING POTENTIAL

Background: Soil-derived fungi represent an important source of bioactive metabolites and volatile compounds with potential applications in the flavour and fragrance industries. Trichoderma species are known for their diverse metabolic capabilities, including the production of vo...

The Effects of Continuous Venovenous Hemofiltration on Immunosuppressive Drug concentrations in an Ex‐Vivo Model of the critically Ill Adult: (CITRIC) study

BACKGROUND: The pharmacokinetics of immunosuppressive drugs during continuous kidney replacement therapy (CKRT) modalities such as continuous venovenous hemofiltration (CVVH) are poorly understood, yet these drugs are crucial for transplant and critically ill patients. METHODS: A...

Estimating the Extent of Missed Opportunities for Osteoporosis Treatment Before Hip Fracture Occurrence

Abstract Hip fractures (HF) are among the most serious consequences of osteoporosis. Many individuals who subsequently sustain a HF may already fulfill recognized criteria for fracture risk assessment, bone mineral density (BMD) evaluation, or anti-osteoporosis treatment before t...

E8‑Phi‑Structured Phononic Information Transfer — E8 Intelligence Research

By re‑interpreting the 240 E8 root vectors as a hyper‑connected mesh of φ‑scaled sub‑wavelength resonators, we create a directional, lossless phonon conduit that propagates phase‑coherent edge modes anchored at the 132 Hz fundamental while recursively branching through φ‑scaled h...

Fostering Communication, Collaboration, Critical Thinking, and Creativity via Educational Robotics

Abstract Communication, collaboration, critical thinking, and creativity—often referred to as the “4Cs”—are regarded as essential soft skills to meet the complex demands of today’s workforce. Consequently, it may be useful to facilitate the acquisition of these abilities from an...

NET-mediated immunothrombosis in ischemic stroke: pathobiology, biomarkers, and therapeutic targeting

Ischemic stroke is increasingly understood not as a purely thromboembolic event but as a thromboinflammatory disease in which innate immune and hemostatic pathways interact. Neutrophil extracellular traps (NETs) have emerged as potentially important mediators and biomarkers withi...

Simulation Model for Measuring the Effectiveness of the Learning Process: Universal vs. Individual Educational Pathway

The study is devoted to examining the effectiveness of introducing an individual educational trajectory in higher education. Achieving this goal requires solving the problem of modelling educational activity implemented in two ways: the first is characterized by a single curricul...

Chemical Profiling and Persistence of Gasoline Residues on Natural and Synthetic Porous Substrates under Tropical Weathering Conditions

Understanding the persistence of gasoline residues on porous substrates is fundamental to arson investigations, which may provide critical evidence of malicious intent through the identification of ignitable liquid residues (ILRs). In forensic practice, delays between fire suppre...

NLRP1 Inflammasome is Associated to IL-18 in Familial Mediterranean Fever and MEFV Variants

Abstract “Familial Mediterranean Fever (FMF) (OMIM #249,100) is the most prevalent hereditary autoinflammatory disease globally, though it remains rare outside Mediterranean populations. FMF is caused by gain-of-function mutations in the MEFV gene, which encodes the immune regula...