Research works

Radiation Beat Frequency Incommensurability: Resolving Quantum Level Repulsion and Riemann-Type Spectral Rigidity via Finite-Shell (n ≤ 8) Orbit Ratios (1/n²)

For over half a century since the historic encounter between Montgomery and Dyson, the exact correspondence between the pair correlation of non-trivial Riemann zeta zeros and the eigenvalue spacing statistics of complex quantum systems has remained an open foundational puzzle—fre...

Dynamical and conformational behavior of a polymer in a crowded solution

We investigate the structure and dynamics of a polymer in a fluid containing mobile spherical colloidal crowders of radius R. We compare and contrast the behavior with Langevin dynamics (LD) and lattice Boltzmann molecular dynamics (LBMD), the latter incorporating long-range hydr...

Niche-resolved transcriptional programs and ΔNp63/NRF2-associated enrichment in post-chemoradiation esophageal squamous cell carcinoma

Spatial organization in esophageal squamous cell carcinoma resection specimens after chemoradiation remains poorly characterized. We profiled 56 patients using Visium spatial transcriptomics and identified eight niches. All 37 evaluated transcriptional signatures showed marked va...

Multiscale modelling of ferroelectrics using a physics-informed neural network driven by molecular dynamics data: parameter identification and field reconstruction

Abstract In multiscale modeling of ferroelectric materials, a fundamental challenge is to transfer discrete atomistic information into a continuum phase-field model (PFM) while retaining an accurate description of mesoscale behavior. In this paper, a physics-informed neural netwo...

Integrating the liver into the cardiovascular-kidney-metabolic syndrome: pathophysiology and therapeutic implications

PURPOSE OF REVIEW: This review examines the mechanistic, epidemiological and therapeutic evidence underpinning liver integration into the cardiovascular-kidney-metabolic (CKM) construct. For the purposes of this review, we use the term cardiovascular-renal-hepatic-metabolic (CRHM...

Longitudinal analysis of the B-cell receptor repertoire across 30 years of ageing

Abstract Background The gradual decline in the functionality of the immune system during aging is commonly referred to as immunosenescence. This study aims to investigate changes in the B-cell receptor immunoglobulin heavy chain (BCR IGH) gene repertoire during natural aging and...

Sea Level Emulator Intercomparison Project (SLEIP) Phase 1: Assessing emulated multi-century global mean sea level projections

Abstract. Simplified sea level modelling approaches calibrated against reference data, also referred to as sea level emulators, can explore future sea level rise and associated uncertainties with low computational cost. Here, we introduce the Sea Level Emulator Intercomparison Pr...

Increased maximum carbon release offsets half of the growth trend in annual land carbon sink

The terrestrial carbon sink has strengthened in recent decades through enhanced maximum CO2 uptake (MCU) and a longer carbon uptake period (CUP), whereas maximum CO2 release (MCR) remains less quantified. Using atmospheric inversion estimates and 16 terrestrial biosphere models,...

Pharmacologic Management of Pain in Children: Balancing Evidence, Safety, and Clinical Challenges

Pain in children remains frequently underrecognized and undertreated despite significant advances in pediatric analgesia. The pharmacologic management of pediatric pain is challenging due to developmental differences in pharmacokinetics and pharmacodynamics, variability in drug m...

Regulatory mechanisms of maternal imprinting at the murine Dlk1-Dio3 domain

Abstract Genomic imprinting is an epigenetic process causing parent-of-origin specific gene expression. The Dlk1-Dio3 domain is one of the largest imprinted clusters. While DNA methylation at an intergenic CpG-island (IG-CGI) within the imprinting control region (ICR) controls ex...

High altitude precipitation dynamics using long-term observations in a Himalayan catchment

Abstract. In the Himalayas, the interaction between climate, orography and land cover results in a highly heterogeneous precipitation pattern. Mountain precipitation, being the main driver of the water cycle, ultimately provides water for millions of people downstream. Our curren...

Governing AI data-centre resources before consumption: the zero framework

Abstract AI data-centre sustainability is usually evaluated after electricity, water and materials have already been committed. This Perspective develops ZERO as an operational governance framework that moves the decision boundary upstream through hard admissibility constraints,...

Development of a rapid assessment method for responsible use of generative AI in scientific research: Application to the Ugandan research context

Abstract Objective Researchers are increasingly using generative artificial intelligence (GenAI) to support tasks such as literature review, academic writing, programming, data interpretation, and knowledge synthesis. We developed a Rapid Assessment Method for Responsible Use of...

Single-Molecule AFM-Based Force Spectroscopy Reveals VLA-4/VCAM-1 Interactions Underlying Chemokine-Independent B16 Melanoma Cell Arrest

Integrin-mediated adhesion is essential for leukocyte trafficking and contributes to hematogenous tumor metastasis. We recently showed that metastatic B16 melanoma cells undergo VLA-4-dependent rolling and rapid arrest on endothelial cells under physiological shear flow without c...

Spatiotemporal Dynamics in Predator–Prey Models Incorporating Time Delay and Harvesting

A three-compartment predator-prey model (prey, middle predator, top predator) is developed by integrating spatial diffusion, discrete time delays (gestation and biomass conversion), and proportional harvesting on the two lower trophic levels. The objectives are to formulate the m...

Spatio-Temporal Forecasting and Continuous Spatial Reconstruction of Fire Radiative Power Using Sequential GSTARX-IDW and Ordinary Kriging

This study presents a sequential hybrid spatio-temporal forecasting framework combining the Generalized Space-Time Autoregressive with Exogenous Variables (GSTARX-IDW) model and Ordinary Kriging (OK) to model and map weekly Fire Radiative Power (FRP) dynamics in West Kalimantan f...

Fluid Injection Triggers Large‐Scale Slow‐Slip Activation of the Rocky Mountain Fold and Thrust Belt

Abstract Using interferometric synthetic aperture radar (InSAR) we show that hydraulic fracturing treatments near the subsurface deformation limit of the Rocky Mountain Fold and Thrust Belt produced 12 intraplate, aseismic, slow‐slip events with magnitudes 4.71–5.06 at 1,640–2,41...

Mechanical Behavior of 3D PolyJet-Printed Nylon 66/Photopolymer Textile Laminates

Large-area three-dimensional polyjet printing (3DPP) of continuous photopolymer laminates directly onto knitted fabrics provides a potential route toward technical textile applications beyond localized decorative features. This study investigated acrylic photosensitive resin (APR...

Living with stroke-related visual impairment: a qualitative exploration of lived experience, self-management, and support needs

PURPOSE: Stroke-related visual impairment (SRVI) is common but often under-recognised and inconsistently supported. While clinical features and acute rehabilitation are documented, less is known about how people live with SRVI over time or whether services meet changing needs. Th...

A metal-dielectric photonic crystal-based glucose sensor with sensitivity enhancement by using 2D materials

Abstract Metal-dielectric photonic crystals (MDPhCs) that support the excitation of Bloch-like surface waves (BLSWs) at the interface of an MDPhC and the adjacent medium (analyte) have emerged as a very promising alternative for sensing gaseous analytes with high sensitivity. In...