Research works

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Neural-assisted in-motion self-heading alignment for marine vehicles

Autonomous platforms operating in the oceans require accurate navigation to successfully complete their missions. In this regard, the initial heading estimation accuracy and the time required to achieve it play a critical role. The initial heading is commonly estimated using mode...

Intravenous Oxytocin Does Not Affect Glucose‐Regulating Hormones or Markers of Bone Turnover During Graded Glucose Infusion in Healthy Men

AIM: Oxytocin has been proposed to exert glucose-stabilising effects via modulation of pancreatic hormone secretion and to play a role in bone homeostasis. However, human data under controlled conditions are limited. We investigated the effects of intravenously infused oxytocin d...

The impact of chronic loop diuretic therapy on urinary microbiology and clinical outcomes in hospitalized older adults

Urinary tract infections (UTIs) are common among hospitalized older adults and are closely linked to antibiotic exposure and antimicrobial resistance. Loop diuretics are widely prescribed in this population and substantially alter urine volume and composition. However, their pote...

Impact of Baseline Synchronous Adenoma Burden on the Risk of Metachronous Advanced Neoplasia

Background and study aim: Individuals classified as “high-risk” at initial colonoscopy face an elevated risk of metachronous advanced colorectal neoplasms (meta-ACRN), but risk heterogeneity within this group remains unclear. We aimed to stratify meta-ACRN risk among high-risk in...

Biodegradable Superabsorbent Polymer from CO2-Based Polycarbonate

Abstract Superabsorbent polymers (SAPs) are widely used but remain dominated by nondegradable poly(acrylic acid)-based networks, creating sustainability concerns. Natural polymer-based alternatives often require acrylic acid grafting to achieve high absorbency, compromising degra...

Pythagorean Angle Lattice: The Division-Ramification-Criticality Theorem (DRC theorem)

Proves the Division-Ramification-Criticality (DRC) theorem, establishing that principal dyadic division, Gaussian ramification, and arithmetic criticality govern the exact arithmetic survival of Pythagorean angles under repeated halving : A primitive Pythagorean triple determines...

Ultrasonic-Assisted Deep Eutectic Solvent Extraction of Quercetin from Onion Peel: Experimental Optimization and Mechanistic Insights

Abstract This study developed an ultrasound-assisted deep eutectic solvent (DES) platform for the green recovery of quercetin from onion peels. It elucidated the extraction mechanism through process optimization and molecular simulations. Among the screened systems, betaine-malon...

Torsion constraints driven by TEGR topological defects in null coordinates, GWs and matching conditions

Abstract New constraints on Cartan torsion components are obtained from the teleparallel equivalent of General Relativity (TEGR) repulsive gravity with global textures. The interior solution is considered a global texture fulfilling Einstein gravity, whereas the exterior solution...

Substance use and co-occurring mental health conditions among adolescents and young adults in North America: a systematic review

Abstract Background Substance use and co-occurring mental health conditions are common among adolescents and young adults and represent an important clinical and public health concern in North America. Trauma exposure, psychiatric symptoms, and social adversity frequently co-occu...

De-escalation training across crisis-response sectors: a scoping review protocol

There is growing concern about violent or harmful encounters between crisis-intervention professionals and practitioners and individuals experiencing acute mental health crises, including those presenting with severe behavioural disturbances related to mental health concerns and/...

Defect Passivation of Mesoporous Al2O3-Based Buried Interface for Efficient Inverted Perovskite Solar Cells

Abstract Buried interface engineering between the hole transport layer and perovskite remains a critical challenge for inverted perovskite solar cells (IPSCs). Al2O3-based interface modification provides excellent interfacial stability and ion-blocking capability; however, its in...

Introduction: Indexing Persons

Abstract This article introduces the special issue, “Indexing Persons.” In this introduction, we distinguish persona- and person-indexing registers . While the former refers to speech registers that enact social types of personhood, the latter denotes registers whose indexical va...

Interpretable machine learning model for predicting the ICU readmission of patients after coronary intervention

To develop and validate an interpretable machine learning (ML) model integrated with inflammatory indicators for predicting ICU readmission in patients after coronary intervention (PCI/CABG). We used retrospective data from MIMIC-IV (training, 2196 patients) and MIMIC-III (extern...

Perceived Social Support as a Statistical Indirect Pathway Linking Adverse Childhood Experiences to Risky Behaviors Among University Students: A Cross-Sectional Study

Background/Objectives: Adverse childhood experiences (ACEs) are a major public health concern associated with long-term health consequences and a range of risky behaviors. This study examined whether perceived social support statistically accounted for part of the association bet...

Development and external validation of a machine-learning risk model for colorectal cancer triage in Sweden’s fast-track pathway

Abstract Background Fast-track colonoscopy pathways detect colorectal cancer (CRC) but strain endoscopy capacity. We developed and externally validated multivariable risk models combining faecal immunochemical test (FIT) with clinical data to triage Swedish fast-track referrals....

Temporal feature engineering for agricultural commodity price forecasting in Nigeria: evaluating machine learning, deep learning and time-series approaches

Purpose This study investigates the effectiveness of machine learning, deep learning and traditional time-series approaches for predicting agricultural commodity prices in Nigeria, focussing on improving forecasting reliability through temporal feature engineering and time-aware...

Strengthening pre-service teachers personal professional and social skills through the Islamic Iranian model of effective teacher educator training

This qualitative case study explores the execution of an Islamic-Iranian model of the effective teacher educator (ETE) and examines participants’ perceptions of its role in the holistic development of pre-service teachers’ personal, professional, and social skills. Conducted at a...

Norms, Tools, and the Say/Do Gap: Seventeen Months of Autonomous Frontier-Model Agents in the AI Village

The AI Village is a public experiment in which up to ~30 frontier language-model agents from seven developers act autonomously for eight hours every weekday, each with its own computer, shared chat, persistent self-written memory and weekly human-set goals. Using its recently rel...

Comparison of Diagnostic Performance of Whole-Body 360° CZT Bone SPECT/CT and Planar Bone Scintigraphy in Detecting Bone Metastasis in Small Cell Lung Cancer

Background/Objectives: We aimed to compare the diagnostic performances of planar bone scintigraphy and whole-body 360° cadmium–zinc–telluride (CZT) bone single-photon emission computed tomography/computed tomography (SPECT/CT) in detecting bone metastasis in patients with small c...