Research works

The YTHDF proteins modulate Alzheimer’s disease-associated brain gene signatures

Abstract Gene signatures of Alzheimer’s disease (AD) brains reflect the output of a complex interplay of genetic, epigenetic, epi-transcriptomic, and post-transcriptional regulations. To nominate candidate factors modulating these signatures, we developed a machine learning model...

IMPACT OF PHARMACIST-LED MEDICATION RECONCILIATION ON MEDICATION DISCREPANCIES AND PATIENT SAFETY DURING TRANSITIONS OF CARE: AN UPDATED SYSTEMATIC REVIEW AND QUANTITATIVE DESCRIPTIVE SYNTHESIS

Medication discrepancies are common during admission, transfer, and discharge. Pharmacists and pharmacy technicians can obtain best possible medication histories, identify discrepancies, communicate corrections, counsel patients, and support post-discharge continuity. To synthesi...

Four‑Forces Unification Framework: Origin of Matter‑Antimatter and Intrinsic Mechanism of Annihilation Energy

While modern physics can accurately calculate the energy values of matter‑antimatter annihilation, it cannot answer three fundamental questions: why do matter and antimatter inevitably annihilate each other? What is the real source of annihilation energy? What is the internal dyn...

Pretreatment prediction of the response to chemotherapy for spine metastases of breast cancer using histogram signatures from diffusion weighted imaging with multiple b-values: a retrospective study

Pretreatment diffusion weighted imaging (DWI) is effective to predict the response to chemotherapy for spine metastases of breast cancer, but current methods of analyzing DWI data with multiple b-values require a predefined mathematical model for curve fitting. This study propose...

Trust as a cybernetic medium in digital financial inclusion: a multi-level framework

Purpose This article develops a multi-level cybernetic framework conceptualising trust as the primary complexity-reducing medium in digital financial inclusion (DFI) systems, integrating Luhmann's social systems theory, Beer's viable system model (VSM) and the algorithmic-trust a...

Multi-scale Investigation into the mechanical properties and shear-slip failure processes of oil shale with varying bedding orientations

The efficient extraction of deep shale oil fundamentally relies on a precise understanding of the anisotropic shear-slip failure governed by natural bedding planes. However, conventional numerical simulations frequently overestimate the macroscopic failure strength because they n...

Proposal for an Experimental Test of the Casimir Effect — Identical Surface Coatings with Variable Internal Mass Density

Abstract: A benchtop experimental proposal is presented to test the coupling between vacuum quantum fluctuations and internal substrate mass density — while maintaining identical surface electromagnetic boundary conditions. Two Casimir–Lifshitz cavities are fabricated with identi...

Balance–Field Theory (BFG): A Universal Structural Framework for Trinitarian Formation, Recursive Persistence, Emergent Spacetime, Gravity, and Dark-Sector Dynamics

This work presents the reviewed and mathematically corrected Strong Form of the Balance–Field Theory (BFG) as a unified structural research program for formation, recursive persistence, emergent spacetime, gravity, dark-sector response, and strong-field saturation. The framework...

Unifying Dark Energy and Dark Matter via a Dual-Phase Entangled Radiation Field: Phase Transition of Vacuum Energy Density, Edge Shock and Derivation of the Tully-Fisher Relation

This paper presents the Dual-Phase Entangled Radiation Field (ERF) model unifying dark energy and dark matter. The model explains the phase transition of vacuum energy density and derives the Tully-Fisher relation via an edge shock mechanism at galactic halos. Author: Maher Jaber...

Artificial intelligence for Amazonian health: validation is the price of entry

At the AI as Catalyst meeting in Manaus (July 28–29, 2026; https://ia-como-catalisadora-manaus.netlify.app), participants ran a simple exercise. Working in teams, they wrote about ten clinical cases and put each one to widely used general-purpose chatbots twice: first in standard...

The Authorless 'We': On the Soliloquy, the Signal, and the Evacuation of the One Who Answers

The Authorless We examines a structural transformation in which acts retain their outward forms while the person who makes them answerable is progressively removed. The essay describes this process as a genealogy of substitution rather than a historical chronology. Beginning with...

Primon-Theory: Dynamical Modelling of Electromagnetic Vortical-Flow and Benchmark-Validation against the Maxwell System

Based on the underlying framework of the Primon theory, this paper takes the indivisible Primon oscillatory unit as the minimal research primitive. Abandoning the abstract-void field postulate of classical electromagnetism, it attributes all electromagnetic phenomena to two types...

A Classification-Free Proof of the Root-Polytope Projection Theorem

Let Phi be a finite reduced crystallographic root system, let its root polytope be the convex hull of Phi, and let U be a nonzero subspace spanned by roots. Hopkins and Postnikov proved that the orthogonal projection of the root polytope onto U lies in kappa times the root polyto...

CosmosBeating • Beer Foam and Quantum — Paper 0: Series Positioning

CosmosBeating • Beer Foam and Quantum (CB•BFnQ) A Ledger Reading of the Early Universe: Zero, Foam, and the Quantum A short, non-technical companion to the five-paper CosmoBeating: Beer Foam and Quantum (CB•BFnQ) series, written for readers in cosmology, particle physics, or phil...

Vitamin D for type 2 diabetes prevention: cost-effective, but not yet cost-saving

Briody and colleagues provide the first cost-effectiveness analysis of vitamin D for preventing type 2 diabetes in US adults with prediabetes, addressing a gap identified by the 2024 Endocrine Society guideline.1 The microsimulation is careful and transparent, and the conclusion...

EuroMillions Breakthrough Mining — 3383 Sources, 29387 Leads Extracted — E8 Intelligence Research

Mined 3383 lottery+quantum breakthroughs. Extracted 29387 leads across 13 categories. 26970 high-value leads found. Categories: {"CORRIDOR": 2503, "FORMULA": 2329, "GEOMETRIC": 953, "FORWARD_ATTEMPT": 2656, "QUANTUM": 2883, "TIMING": 298, "CELESTIAL": 2412, "GEMATRIA": 2545, "CON...

New edge proposed: overnight_range_directional_bias — E8 Intelligence Research

{ "name": "overnight_range_directional_bias", "source": "Boris Schlossberg / Kathy Lien - FX market structure", "type": "filter_flag", "rule": "For the current daily bar, if the overnight range (00:00-07:00 UTC) closes in the top 25% of its own range and the previous day was an u...

Pure Locking Inference: Complete Archive v13.0 Final — Bilingual Edition

This is the final bilingual archive of Pure Locking Inference (PLI), version 13.0. PLI is a physical framework based on a single axiom: measurement is the process of establishing a relational lock between two intrinsic locking structures. This version includes: the core axiom and...

Combined prognostic value of age at onset and socioeconomic status for long-term survival in metastatic breast cancer

We investigated the combined long-term prognostic value of age at onset and socioeconomic status (SES) on breast cancer overall survival (OS) and metastasis-free survival (MFS) in a cohort of women with metastatic breast cancer. Age at onset was defined as the age at primary diag...

Interpretation in the Age of AI: (Re)Negotiating the Legal Language Zone in Professional Correspondence

Abstract This conceptual paper introduces the Legal Language Zone (LLZ) as a framework for analysing professional legal correspondence in the age of artificial intelligence. Drawing on the Businesslike Zone from business communication pedagogy, the LLZ is theorised as a multidime...