Research works

When Cancer Research Met Artificial Intelligence: From Machine Learning to Intelligent Oncology

Cancer research and artificial intelligence have developed from distinct scientific traditions, yet their trajectories are increasingly converging. [...]

Medical Mystery

Introduction: Roleplays are used in medical education to provide trainees with a safe environment for developing and improving their skills. Roleplays have traditionally been designed and facilitated by clinicians and educators. This study investigates the feasibility and scalabi...

Conservative versus liberal oxygen therapy for mechanically ventilated adults: a systematic review with meta-analysis and trial sequential analysis

Optimal oxygen targets for mechanically ventilated adults remain uncertain. Prior meta-analyses included both ventilated and non-ventilated patients, limiting applicability to invasive ventilation. We performed a PRISMA-compliant systematic review and meta-analysis of randomized...

PdCP1 from Penicillium digitatum Acts as a Protein Elicitor to Control Postharvest Decay and Preserve Quality in Citrus Fruit

Abstract Citrus fruits are susceptible to infection by Penicillium digitatum, causing significant economic loss. Exploring eco-friendly control strategies is therefore critical. Here, we identified and heterologously expressed a novel secreted protein, PdCP1, from P. digitatum an...

Beyond the Bulk: Fraction-Specific Total Organic Carbon Profiling for Proactive Water Quality Management

Abstract Total organic carbon (TOC) is widely used to monitor water quality, but its value as a single metric is increasingly limited in water management. Bulk TOC does not distinguish organic fractions with different reactivities and associated risks, limiting its ability to pre...

Numerical Investigation on Flow-Induced Vibration Characteristics of Pipe-in-Pipe Auxiliary Pipe System

A pipe-in-pipe structure with a buoyancy damping layer is designed to reduce pipeline weight and suppress vortex-induced vibration. This structure avoids structural pre-stress problems caused by external buoys and mitigates severe local vibration. The four-degree-of-freedom motio...

The paradox of innovation: New concepts and disruptiveness in science

This study examines the relationship between the introduction of new concepts and scientific disruptiveness using more than 42 million publications published between 1950 and 2024. We find that papers introducing new concepts are, on average, less disruptive than papers without n...

When God Arrived With a Government: When Salvation Required Surrender and Christianity Policed the Soul

An interpretive historical essay examining Portuguese Goa as a case in which evangelization operated within a colonial state able to alter sacred space, civil status, language, memory, and the terms of religious choice. Moving from the conquest of 1510 and Francis Xavier's reques...

All-cause mortality and associated factors among adults living with HIV receiving antiretroviral therapy in the Sughd region of Tajikistan: a retrospective cohort study, 2013–2022

Abstract Background Despite expanded access to antiretroviral therapy (ART), HIV-related mortality remains a concern in resource-limited settings. We assessed all-cause mortality and the factors associated with death among adults receiving ART in the Sughd region of Tajikistan. M...

Phi-Quasicrystalline E8 Lattice: A Scale-Invariant Quantum Error Code — E8 Intelligence Research

By imposing golden-ratio scaling on the 240 E8 root vectors entrained at the 132 Hz base frequency, the resulting lattice acquires a hybrid periodic-aperiodic order that maps naturally onto a quantum error-correcting code. The phi-induced quasicrystalline symmetry breaks translat...

How Patients Define Quality in Dental Care: A Qualitative Systematic Review

Patient-centered care is central to high-quality health care, yet systems-level understanding of how patients themselves define dental care quality remains limited. This systematic review synthesized qualitative evidence using the Donabedian framework to examine patients' percept...

Networks and genome-resolved analyses reveal persistent particle-mediated coupling between prokaryotes and eukaryotic plankton

Interactions between bacterioplankton and eukaryotic plankton are often inferred from short-lived algal blooms, leaving it unclear whether coupling persists under natural seasonal variability and which traits sustain it. We conducted seasonal sampling of coastal seawater over an...

Community-based health screening in Madagascar reveals a potential underestimation of non-communicable and infectious disease burden: a cross-sectional study

To assess the prevalence of selected communicable diseases and cardiometabolic risk factors in adults from underserved inland and coastal communities in Madagascar. A community-based cross-sectional study was conducted in two underserved peripheral communities settings (inland an...

Application of guideline-directed medical therapy in women with chronic heart failure

To analyze the implementation status of guideline-directed medical therapy (GDMT) in women with chronic heart failure (HF). This cross-sectional study included women with chronic HF admitted to Lanzhou University Second Hospital from January 2022 to December 2025. Patients were c...

Phytochemicals Modulating Receptor Tyrosine Kinase Signaling Networks in Endometriosis

Endometriosis is a chronic, estrogen-dependent inflammatory condition that is marked by the growth of lesions outside the uterus, along with angiogenesis, fibrosis, immune dysregulation, and pain sensitization. There is now growing evidence that receptor tyrosine kinase (RTK) sig...

Firm Size, Skills, and the Conversion of Generative AI into Productivity: Evidence for Spanish Manufacturing — pre-specified design lodged before data access

This deposit lodges the empirical design of a study of generative-AI adoption and total factor productivity in Spanish manufacturing, before the author has accessed the microdata the study requires. The paper distinguishes the task-level potential of generative AI from its firm-l...

The Poincaré Homology Sphere and the Fine-Structure Constant: What Follows from a Point Being Here, with the Status of Every Step

This text follows a single definition — a point is here: from itself, surrounded by others — along one thread, and marks at every step what carries the step: a theorem (cited, or a uniqueness by exclusion in which every alternative is named and shown to be a mark), a name (a deri...

Gödel's Incompleteness: True Statements Beyond Formal Proof's Reach — E8 Intelligence Research

FINDING: Gödel's First Incompleteness Theorem demonstrates that any consistent, recursively enumerable formal system capable of expressing basic arithmetic contains true but unprovable statements — a structural limit on formal proof itself. | MATH: Let T be a consistent, recursiv...

A parameter-invariant activity threshold for the erasure of spatial pattern in active Model H

Solver, sweep scripts and trajectory data for the paper "A parameter-invariant activity threshold for the erasure of spatial pattern in active Model H" (R. M. Chen). An imposed stripe pattern in a conserved order-parameter field coupled to a Stokes solvent is destroyed by active...

Vibration transmission and damping characteristics of double-layer non-linear fasteners

As a widely used fastening type in urban rail transit, a fastening system equipped with a double-layer non-linear rubber pad largely compensates for the insufficient elasticity of ballastless track systems. Studying the vibration transmission characteristics within double-layer n...