Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
145612 work(s)
- Health & MedicineOpen access
Rapid and accurate detection of drug-resistant Mycobacterium tuberculosis is critical for effective patient management and tuberculosis (TB) control. Targeted next-generation sequencing (tNGS) assays such as Deeplex® Myc-TB offer rapid detection of resistance-associated mutations...
- Health & MedicineOpen access
Background Monitoring the prevalence and serotype distribution of Streptococcus pneumoniae nasopharyngeal carriage is essential for understanding transmission dynamics and assessing the impact of pneumococcal conjugate vaccines (PCVs). In Brazil, PCV10-GSK is routinely administer...
- Health & MedicineOpen access
To evaluate the incidence, clinical characteristics, primary management strategies, and long-term outcomes of urinary tract injuries after major gynecological surgeries. A retrospective analysis was conducted on a cohort of 34,568 major gynecological surgeries performed at our in...
- Health & MedicineOpen access
Centella asiatica (L.) Urban extracts are widely used in food, cosmetic, and pharmaceutical products. Conventional solvent extraction requires organic solvents and often produces dark green extracts due to chlorophyll co-extraction, limiting their industrial applications. This st...
- AI & ComputingOpen access
Architectural Specification of a Local Multi-Scale Contour for Stable Recursive Self-Improvement
This document describes a practical architecture for stable recursive self-improvement limited to programming, algorithms, and mathematics. The system runs as a bare core and does not require broad world knowledge or data-center resources. It is designed for 1 to 5 high-end local...
- Health & MedicineOpen access
Background/Objectives: Polyendocrine metabolic ovarian syndrome (PMOS) is characterized by hyperandrogenism, particularly excessive testosterone, as a core clinical feature and a key pathogenic metabolite, yet its molecular mechanisms remain incompletely understood. Methods: This...
- Materials & EnergyOpen access
Abstract The molecular parameters that influence emissive-state formation and excited-state relaxation in nonconventional fluorophores remain poorly understood. Here, we use structurally related choline–carboxylic acid ionic liquids (ILs) derived from valeric acid (CAVA), levulin...
- Materials & Energy
ActiveFusion: Fused Representations Improve Active Learning for Molecular Property Prediction
Abstract Active learning provides an efficient strategy for molecular property prediction by iteratively prioritizing compounds for experimental evaluation. However, the effectiveness of active learning pipelines depends strongly on the choice of molecular representation, and sys...
- Climate & EnvironmentOpen access
Abstract Lichens play an important role in rock alteration across diverse terrestrial environments, yet the relative contributions of biomechanical and biochemical processes under different climatic conditions are still poorly constrained. Here, we investigated interactions betwe...
- Health & MedicineOpen access
Background/Objectives: Irritable bowel syndrome (IBS) is one of the most common disorders of gut–brain interaction and one of the most frequent functional bowel disorders encountered in clinical practice. The lack of reliable biomarkers, coupled with inconsistent clinical present...
- Health & Medicine
Embolic stroke of undetermined source (ESUS) accounts for approximately one-third of all ischemic strokes. Atrial cardiomyopathy, independent of paroxysmal atrial fibrillation, is an increasingly recognized embolic substrate. Left atrial (LA) strain assessed by speckle-tracking e...
- Health & Medicine
Orofacial manifestations of an overlap syndrome: a report of progressive polyautoimmunity.
Autoimmune disorders exhibit several clinical symptoms, pathophysiological processes, and genetic components, which result in an autoimmune tautology, suggesting that they share similar etiological pathways. Systemic Sclerosis (SSc), also known as Scleroderma, is a potentially fa...
- BiologyOpen access
Glycolipid metabolic crosstalk in tumor immune evasion and therapeutic targeting
Tumor immune evasion remains a major barrier to effective cancer immunotherapy and is closely associated with metabolic reprogramming. Glucose and lipid metabolism are highly interconnected processes that cooperatively reshape the tumor microenvironment (TME), regulate immune-cel...
- Biology
Selectivity Filter KCND3 Variant Causes Spinocerebellar Ataxia 19/22 and K V 4 .3 Functional Loss
Abstract Background Spinocerebellar ataxia type 19/22 (SCA19/22) is a rare autosomal dominant neurodegenerative disorder caused by KCND3 variants encoding the K V 4.3 potassium channel. While most pathogenic variants result in loss‐of‐function (LOF), no pathogenic variants were p...
- Biology
OBJECTIVE: This study aimed to detect and characterise signals of disproportionate reporting for smell and taste disorders associated with Z-drugs in the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS). METHODS: Reports involving Z-drugs and smell/taste...
- BiologyOpen access
Base-pair resolution ATAC-seq during macrophage/neutrophil differentiation
Abstract Objectives The differentiation of cells during development and adult homeostasis requires extensive remodeling of the epigenome at multiple scales, from transcription factor binding sites (TFBS) to domains spanning hundreds of kilobases. We profiled the accessibility lan...
- Biology
Colorectal cancer remains a leading cause of cancer-related mortality worldwide. While chemotherapy and radiotherapy serve as a cornerstone of treatment, their clinical efficacy is frequently compromised by therapeutic resistance and gastrointestinal toxicity. Accumulating eviden...
- Engineering & Technology
Developing advanced secondary batteries to adapt to the increasingly stringent performance requirements demands a fundamental rethinking of battery regulation strategies. Active electrochemical regulation strategies for secondary batteries are an innovative shift from static mate...
- Engineering & TechnologyOpen access
Conventional sound-source localization derives direction of arrival from inter-sensor delay, phase, or level differences, leaving nearly all directional discrimination to the sensor array and to post-sampling processing. This work realizes the complementary principle: the passive...
- Society & EconomicsOpen access
In contemporary building design, historical environments and buildings serve as important references for interpreting architectural materials, colors, proportions, construction methods, and facade elements. Imitative architecture reproduces or reinterprets recognizable characteri...