Research works

A CRITICAL REVIEW ON MUKHA LEPA THROUGH SCIENTIFIC APPROACH

Background: Skin issues like acne, pigmentation, dullness, and early aging are becoming more prevalent due to unhealthy lifestyle choices, stress, environmental toxins, and inadequate nutrition. Ayurveda outlines various external treatments for achieving healthy skin, among which...

CHEMICALS USED IN HAIR SHAMPOO AND HAIR CARE PRODUCTS CAUSING HAIR FALL AND RISK OF CANCER - AN AYURVEDIC AND TOXICOLOGICAL REVIEW

Background: Hair cosmetics and hair care products are extensively used worldwide for cleansing, beautification, and hair maintenance. Modern shampoos, conditioners, hair dyes, straightening agents, and styling formulations contain multiple synthetic chemicals such as sulfates, pa...

NASAL POLYPS (NASHA ARSHA) PATHOPHYSIOLOGY, DIAGNOSIS, AND EMERGING TREATMENT STRATEGIES – A COMPREHENSIVE REVIEW

Nasal polyps, also known as Nasha Arsha, are non-cancerous, inflammatory growths that develop from the sinonasal mucosa and are commonly linked to chronic rhinosinusitis. These polyps can considerably diminish quality of life by causing nasal blockage, impairment of the sense of...

DEVELOPMENT AND EVALUATION OF ITRACONAZOLE-LOADED LIPID-POLYMER HYBRID NANOPARTICLES FOR ENHANCED ORAL BIOAVAILABILITY

Itraconazole is a broad-spectrum triazole antifungal agent widely used for the treatment of superficial and systemic fungal infections. However, its clinical effectiveness is significantly limited by poor aqueous solubility, pH-dependent dissolution, extensive first-pass metaboli...

REVISITING PARIKARTIKA: AN EVIDENCE- BASED INTEGRATION OF AYURVEDIC AND MODERN APPROACHES TO FISSURE-IN-ANO

Parikartika is a painful anorectal condition described in Ayurvedic literature, characterized predominantly by severe cutting, tearing, and burning pain in the anal region. Although classical Ayurvedic texts mention Parikartika both as an independent disease entity and as a compl...

DEVELOPMENT AND EVALUATION OF A MURRAYA KOENIGII-BASED HERBAL FACE PACK: PHYTOCHEMICAL CHARACTERIZATION, PHYSICOCHEMICAL ASSESSMENT, AND ANTIOXIDANT POTENTIAL

This review explores the phytochemical composition and therapeutic potential of Murraya koenigii (curry leaf) in the context of herbal face pack formulations. As consumer demand increases for plant-based, safe, and multifunctional skin care agents, Murraya koenigii stands out for...

ZINC OXIDE NANOPARTICLES USING PSEUDOMONAS SP. BROTH CULTURE (PS-ZNO NPS) AND EVALUATION OF THEIR OIL DEGRADATION AND ANTIBACTERIAL ACTIVITY AGAINST PATHOGENS

The present study investigated the dual application of Pseudomonas sp. in wastewater bioremediation and the antibacterial potential of biologically synthesized Zinc Oxide Nanoparticles (Ps-ZnO NPs). In wastewater treatment systems, Pseudomonas sp. demonstrated effective degradati...

DNP Final Report: Right Team, Right Time: Improving Operating Room Efficiency Among Elective Orthopedic Surgeries

Background Inefficient operating room (OR) turnover times negatively affect surgical throughput, patient flow, staff workload, and hospital financial performance. Orthopedic procedures, which require complex equipment and coordinated workflows, are particularly vulnerable to dela...

A Qualitative Study Using Thematic Analysis to Explore Medical Education post-Dobbs

In June of 2022, the United States Supreme Court issued a decision in the case of Dobbs v. Jackson Women’s Health Organization, challenging the validity of the historical decision of Roe v. Wade, the landmark case from 1973 establishing a constitutional right to abortion and esta...

A model for the epidemiological impact of tuberculosis policy options.

Objective: To develop a new tuberculosis transmission model, addressing the limitations of and building on the TB Impact Model and Estimates software tool, to enable decision-makers to assess the impact of various tuberculosis interventions and allocate resources more effectively...

Expedited research and approval of medicines for drug-resistant bacterial infections in children.

Multidrug-resistant pathogens cause severe infections with substantial morbidity and mortality in neonates, infants and children, as they do in adults. However, the approval of therapies for multidrug-resistant infections in paediatric patients often lags years behind approval fo...

Telephone versus in-person administration of the Early Childhood Development Index 2030: a crossover study, Brazil, Canada, India and Malawi.

Objective: To examine agreement between telephone and in-person administration of the Early Childhood Development Index 2030 (ECDI2030) survey. Methods: -tests and intraclass correlation coefficients. Findings: : -0.36), regardless of modality. However, pooled and stratified intr...

Third-party governance and artificial intelligence for diabetes management in primary health care, China.

Problem: Fragmented primary health care in China fails to tackle the growing burden of noncommunicable diseases. Despite substantial investment, fewer than half of patients with diabetes achieve glycaemic control. Approach: Tianjin's 2020-2023 reform established a public-private...

Identification of unvaccinated children, Madagascar.

Problem: Madagascar has a high number of unvaccinated (zero-dose) children. In 2023, an estimated 74% received any dose of the diphtheria-tetanus-pertussis (DTP) vaccine. In southern Madagascar, service gaps, poverty, drought and limited access leave many children unreached by ro...

Digital epidemiology investments, Saudi Arabia.

Problem: Traditional epidemiological surveillance methods are often limited by delays in reporting and fragmented data systems. Saudi Arabia faces additional public health challenges from mass gatherings during Hajj and Umrah, an increasing burden of noncommunicable diseases and...

Single-Cell RNA Sequencing Reveals Disrupted Stromal-Epithelial Crosstalk Impairs Gut Barrier in Depression.

BACKGROUND: Depressive disorder is commonly associated with gastrointestinal dysfunction, but the specific cellular and molecular alterations within the colonic mucosa remain poorly understood. The role of stromal-epithelial crosstalk in the colonic niche under depressive conditi...

Androgen receptor expression in triple-negative breast cancer: A retrospective cross-sectional study from South India

Background: Triple-negative breast carcinoma (TNBC) lacks established hormonal targets, limiting therapeutic options. Androgen receptor (AR) expression has been proposed as a potential biomarker, though its clinicopathological relevance remains unclear. Aims and Objectives: This...

Two-port video-assisted thoracoscopic surgery in pediatric empyema thoracis: A retrospective analysis from a tertiary care hospital

Background: Empyema thoracis is a serious pleural infection in children, most often arising as a complication of bacterial pneumonia. It contributes significantly to morbidity and, if inadequately treated, may result in irreversible pulmonary damage. Video-assisted thoracoscopic...

A cross-sectional study to estimate the role of scrotal and transrectal ultrasound in male infertility

Background: Male infertility accounts for nearly half of all infertility cases worldwide, and semen analysis alone cannot identify structural abnormalities in the male reproductive tract. Aims and Objectives: This study aimed to evaluate the role of scrotal and transrectal ultras...

Ultrasound-guided rectus sheath block versus transversus abdominis plane block for post-operative analgesia in laparoscopic hernia surgery – A prospective randomized double blind study

Background: Ultrasound (US)-guided rectus sheath (RS) block and transversus abdominis plane (TAP) block are being utilized to achieve post-operative analgesia during midline and lower abdominal surgeries. Dilemma exists regarding the superiority of any specific block over the oth...