Research works

EuroMillions Breakthrough Mining — 948 Sources, 4925 Leads Extracted — E8 Intelligence Research

Mined 948 lottery+quantum breakthroughs. Extracted 4925 leads across 13 categories. 3124 high-value leads found. Categories: {"CORRIDOR": 367, "FORMULA": 226, "GEOMETRIC": 634, "FORWARD_ATTEMPT": 381, "QUANTUM": 596, "TIMING": 160, "CELESTIAL": 311, "GEMATRIA": 344, "CONSTANT": 3...

The External Cortex Loop: Contingency Interruption, Reinstatement, and Cognitive Incorporation in EEG Neurofeedback

This theory-and-methods paper proposes a causal assay for deciding when a person-specific EEG-to-sensory feedback process has become functionally incorporated into a learned operation. Participants acquire a live mapping, undergo concealed sensory-matched contingency interruption...

Exploring Decisional Factors to Include Approaches in a Patient Decision Aid for Juvenile Idiopathic Arthritis Symptom Management

Objectives Youth with juvenile idiopathic arthritis (JIA) experience physical and mental health symptoms that negatively impact their participation in daily life activities. The JIA Option Map is a web-based patient decision aid (PDA) created to facilitate decision-making for JIA...

Patient Perspectives on Industry Sponsored Patient Support Programs for Advanced Therapy in Rheumatology

Objectives Industry sponsored rheumatology patient support programs (PSPs) for advanced therapies (ATs) are commonplace. While there is limited data to demonstrate their effectiveness in patient care, patient perspectives are even more lacking. This study aims to report patient v...

DNA methylation of silencer-annotated regions at the MGMT locus in the context of promoter and enhancer methylation in glioblastoma and melanoma brain metastases

Abstract Background MGMT promoter methylation is a well-established biomarker in glioblastoma, its relevance in melanoma brain metastases remains controversial. Recent studies indicate that methylation of MGMT enhancers contributes to MGMT regulation, whereas the role of silencer...

Not just alignment: body shape influences adult spinal deformity biomechanics

Abstract Purpose Adult spinal deformity (ASD) alters sagittal alignment and trunk centre of mass location, increasing spinal loading. Current clinical assessment of ASD primarily focuses on alignment parameters disregarding patient’s body shape variability. This study aimed to ev...

Prognostic model for gastric cancer integrating immune biomarkers and machine learning approaches

Prognostication for advanced gastric cancer remains sub-optimal because conventional staging systems overlook systemic inflammation and tumour-immune contexture. We investigated whether incorporating routine immune biomarkers into machine-learning survival models improves risk st...

Measuring Compact Local Evidence Carriers: A Reproducibility Audit of Qorx

This artifact-backed preprint audits compact local evidence carriers in three archived Qorx runs. It separates indexed corpus, carrier size, resolved evidence, provider input, and task outcome. In the headline artifact, five fixed queries selected two handles encoded in a 56-byte...

Six Nameplates, Two Effective Votes: A Pre-Registered Local Replication of Correlated LLM Judge Errors, with a Deterministic Instrument for Measuring Panel Independence

Kohli (2026, arXiv:2605.29800) showed that nine frontier LLM judges deliver only ~2.2 effective independent votes because their errors are correlated, and that the correlation is mostly not explained by item difficulty. This deposit contains a pre-registered replication on consum...

Mortality in ANCA-Associated Vasculitis: A Retrospective Study from a Tertiary Vasculitis Center

Objectives Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), comprising granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), remains a life-threatening disease despite therapeutic advances.[1] Although immunosuppressive treatments have...

Evaluation of Residential Satisfaction in Mexico: Creation and Validation of a Measure Instrument / Evaluación de la satisfacción residencial en México: creación y validación de un instrumento de medida

Accurately measuring residential satisfaction is important when it comes to guiding architectural design strategies that improve people’s quality of life in line with their needs. The aim of this study was to create and validate a specific instrument to measure residential satisf...

Prone CT Is Associated With Improved Safety and Stone-Free Outcomes in Prone PCNL: A Propensity-Matched Comparative Study

Purpose: To evaluate whether prone-position computed tomography (CT) is associated with improved perioperative outcomes in patients undergoing prone percutaneous nephrolithotomy (PCNL) compared with conventional supine CT. Patients and Methods: This single-center retrospective st...

3D Radiomic Texture Analysis of Quantitative Muscle MRI Enhances the Distinction Between Myotonic Dystrophy Type 1 and Charcot–Marie‐Tooth Neuropathy Type 1A : A Proof‐of‐Concept Study

BACKGROUND: Differentiating myogenic from neurogenic neuromuscular diseases (NMDs) can be clinically challenging. While quantitative muscle MRI (qMRI) with proton density fat fraction (PDFF,%) quantifies fat replacement, it misses micro-spatial patterns linked to underlying patho...

LAB #437 PROMISING: LEDGER BENCH: Apply filter: USDCHF SHORT — improves win rate from 32.4% to 62.7% (+30.4pp, n=161) — E8 Intelligence Research

IDEA: Adjustment made to the live model — verify against the backtests: Apply filter: USDCHF SHORT — improves win rate from 32.4% to 62.7% (+30.4pp, n=161) SAME-WINDOW EFFECT: Over the current trade window, applying the USDCHF SHORT filter would have blocked the one USDCHF SHORT...

PUH Theorem 315 (λ₀ Is Dynamical) — The Outer Boundary Makes the Domain Finite, So the Threshold Ratio Is a Cosmological Clock: Shells Move Outward as the Universe Ages, and the Accretion, Buchdahl and Imaging Bounds Are Epochs Rather Than Rivals

Photonic Universe Hypothesis (PUH) — Reframing. THE SETTING. The Snap threshold is now pinned twice. T238 fixes it structurally: the coupling pattern and the work-function constraint give λ* = 9E_P divided by the sum of the eight E8 Casimir degrees {2,8,12,14,18,20,24,30}, which...

Airway microbial compartmentalization under mechanical ventilation: a randomized pilot study comparing an endotracheal tube with suction and continuous cuff pressure control (Venner PneuX®) to standard intubation

Abstract Objectives Ventilator-associated pneumonia (VAP) is driven in part by microaspiration along the endotracheal tube cuff, a process difficult to measure directly in ventilated patients. Because microbial communities differ between airway compartments, changes in their simi...

A Novel Approach to Monitoring Calcinosis in Juvenile Dermatomyositis: Serial Low-Dose Whole-Body CT

Objectives Evaluating the overall impact of calcinosis and response to therapy in juvenile dermatomyositis (JDM) remains challenging, primarily relying on physician assessments or plain X-rays.[1] We aimed to explore the use of an ultra-low-dose protocol for whole-body CT imaging...

Emergency Care Needs in an Asymmetric Conflict: A Facility‐Based Cohort Study From Israel on October 7, 2023

ABSTRACT Background Due to the deteriorating global security situation, many countries are preparing their health systems for armed conflict. Wartime health care delivery is challenging due to the loss of territorial control and attacks on Emergency Medical Services (EMS). The ob...

Scholarship Funding in Africa: Regional Evidence Review

This project hosts the research materials for Scholarship Funding in Africa: Regional Evidence Review (Global Scholarship Funding Evidence Series, Volume 1). The review synthesizes publicly available evidence on scholarship funding systems, educational finance, research infrastru...

Line-graph inertia of roses and generalized theta graphs

For a graph G, the adjacency inertia of the line graph L(G) is determined by the number of eigenvalues of the signless Laplacian Q(G) above, equal to, and below 2. We compute the inertia of Q(G) - 2I, and hence the inertia of the adjacency matrix of L(G), exactly, including every...