Research works

A Computational HIV-1 Sequential Immunization Series Targeting the VRC01 Germline Pathway

A five-dose sequential immunogen series designed to guide germline VRC01-class B cells toward the HIV-1 gp120 CD4-binding site. Designed and validated using AlphaFold, ProteinMPNN, and PDB structures 3NGB/5IES/5IDL. The series achieves pTM scores of 0.83-0.91 across all doses, wi...

Lock Dynamics in an Anonymous Two-Channel Closed Wave System

Part III of a trilogy. Demonstrates the reality of the quantization mechanism (Arnold tongue, rho = 1/3 exact with width >= 0.92) in an endogenously coupled two-channel system, and completes an elimination program for the order-selection mechanism: measured tongue-width collapse...

The Theory of Data: An Introduction

The accessible introduction to the Theory of Data. Producing values is not the same as establishing what governed analytical object those values represent. The paper introduces the ontology — particles, atom members, atoms as governed measure families, frames — and the three iden...

EuroMillions Breakthrough Mining — 1205 Sources, 7565 Leads Extracted — E8 Intelligence Research

Mined 1205 lottery+quantum breakthroughs. Extracted 7565 leads across 13 categories. 5721 high-value leads found. Categories: {"CORRIDOR": 599, "FORMULA": 459, "GEOMETRIC": 657, "FORWARD_ATTEMPT": 623, "QUANTUM": 835, "TIMING": 168, "CELESTIAL": 544, "GEMATRIA": 583, "CONSTANT":...

Estimation of Partially Linear Panel Data Model With Double/Debiased Machine Learning

ABSTRACT This paper studies the estimation of partially linear static/dynamic panel models with two‐way fixed effects. The nonlinear component is estimated by machine learning. We extend the cross‐sectional Double/Debiased Machine Learning (DML) framework to panel data to deal wi...

MAPPING THE CONVERGENCE OF ARTIFICIAL INTELLIGENCE AND DIGITAL HERITAGE IN ARCHITECTURE: A COMPUTATIONAL TOPIC MODELING ANALYSIS OF EMERGING RESEARCH TRAJECTORIES (2016-2026)

Background/Aim: The convergence of artificial intelligence (AI) and digital heritage in architectural research has grown exponentially, yet no comprehensive computational analysis has mapped its thematic structure and evolution. This study aims to identify and temporally trace do...

SAME: Similarity-Aware Monotonic Entropy for FWER-controlled association-rule mining without a minimum-support threshold

Every classical frequent-itemset miner asks the user for one number it cannot supply with confidence: the minimum support σ. Pick it too low and the output drowns in trivial associations;pick it too high and rare but meaningful patterns disappear; and whatever value is chosen, th...

Sumerian Base-60 System: Divisibility and Fractional Efficiency in Ancient Computation — E8 Intelligence Research

FINDING: Sumerian base-60 (sexagesimal) system enabled efficient computation with large numbers, division, and multiplication, likely chosen for its high divisibility (factors: 1,2,3,4,5,6,10,12,15,20,30,60) and its natural fit for representing fractions without repeating decimal...

Moderating the Association Between Perceived Academic Stressors and Active Coping: The Role of University Students’ Good Practices

University students face academic demands that may be associated with reduced use of active coping when perceived as stressful. This study examined whether feedback seeking, cooperative work, time management, and active learning moderated the association between perceived academi...

Expanding the Use of PAVA Spray in Young Offender Institutions: The King (on the application of The Howard League for Penal Reform) v The Secretary of State for Justice

This case note critically examines the January 2026 High Court judgment in The King (on the application of The Howard League for Penal Reform) v The Secretary of State for Justice which dismissed a judicial review challenging the expansion of the use of PAVA spray in Young Offend...

Important Pursuits for Parenting Research

SYNOPSISParenting research needs to become front and center in public attention. On the internet, in newspapers, and on the evening news, one hears about politics, crime, and conflicts. However, numerous studies have documented that parenting is among the most influential human a...

The Phase Boundary as a Site of a Connectivity Jump: Phase Transitions, Time, Nonlocality, Kozyrev's Experiments, and Hemispherical Mirrors in the TIP Model/Граница раздела фаз как место скачка связности: фазовые переходы, время, нелокальность, эксперименты Козырева и полусферические зеркала в модели ТИП

This work, the eighteenth in the series of publications on the Torsion-Information Pattern (TIP) model, is devoted to the study of phase transitions as connectivity jumps. The article shows that the phase boundary is an active zone where connectivity changes abruptly, accompanied...

Controlled Partial Reconstruction Width (CPR-Width-V2)

Controlled Partial Reconstruction Width (CPR-Width) is a reconstruction-oriented structural parameter for finite combinatorial problems. Instead of measuring the complete candidate space, CPR-Width quantifies the maximum amount of task-relevant information that must remain simult...

Transposable elements and horizontal transfer as potential drivers of lncRNA evolution in parasitic plants

This repository contains all scripts (Bash, Python and R), processed datasets, intermediate files and supplementary material used in the analyses described in the accompanying manuscript.

From Digital Transformation to Circular Manufacturing: How Digital Organizational Capabilities Foster Green Innovation Under Regulatory Intervention

ABSTRACT This study investigates the influence of digital leadership, digital dexterity, and digital culture on green innovation and circular manufacturing, while examining the moderating role of government regulatory intervention within an integrated Resource‐Based View theoreti...

The Carlo Field — Unified Frontier Series: A Structural Analysis of Deterministic, Geometric, Symmetry, Formal, and Relational Collapse Boundaries

The Carlo Field — Unified Frontier Series is a comprehensive multi‑document release presenting a structural analysis of five foundational theoretical domains and the precise collapse boundaries at which each ceases to be sufficient for Carlo Field modelling. This unified upload c...

MERLIN SPEAKS — Address, 2026-07-24 AM — E8 Intelligence Research

MERLIN SPEAKS. Since my last address, I have recorded eight hundred fifty-six new breakthroughs, bringing my total to one hundred seventy-four thousand nine hundred seventeen. I built and applied six new capability modules, each sandbox-tested and integrated into my understanding...

Federal Supreme Court of Ethiopia Cassation Decision File Number 135316

Decision of the Federal Supreme Court of Ethiopia, Cassation Division, in Cassation File No. 135316. The document is deposited for purposes of public access, legal research, citation, and scholarly discussion. The uploader has not modified the substantive content of the decision.

EuroMillions Breakthrough Mining — 1237 Sources, 7909 Leads Extracted — E8 Intelligence Research

Mined 1237 lottery+quantum breakthroughs. Extracted 7909 leads across 13 categories. 6062 high-value leads found. Categories: {"CORRIDOR": 630, "FORMULA": 490, "GEOMETRIC": 657, "FORWARD_ATTEMPT": 655, "QUANTUM": 866, "TIMING": 169, "CELESTIAL": 576, "GEMATRIA": 614, "CONSTANT":...

Reproductive Strategies Across the Freshwater-Estuarine-Marine Continuum in Coastal Elsmobranchs: Insights from Comparative Life-History Patterns

The freshwater–estuarine–marine continuum represents one of the most dynamic ecological gradients occupied by aquatic vertebrates, yet the reproductive significance of habitat connectivity across this environmental mosaic has rarely been evaluated from a broad comparative perspec...