Research works

De Novo Computational Design of DARPin Binders Targeting FcεRI Alpha Chain Domain 2 via Structure-Guided Sequence Optimisation, Multi-Seed Deep Learning Prediction and Interfacial Thermodynamic Validation

Abstract Background: Computational design of targeted protein binders against cell-surface receptorsremains a critical frontier in therapeutics and biotechnology. The high-affinity IgE receptoralpha chain (FcεRI) mediates the allergic inflammatory cascade by binding immunoglobuli...

Transient recovery voltage for load current switching test of MV load break switch

Switchgear manufacturers and type testing laboratories conduct the active load-current switching test of MV interrupter switches (load break switch or disconnector) following the guidelines of either the IEEE or IEC standards. However, the testing guidelines defined by these two...

MicroRNA expression profiling in fowl adenovirus serotype 4-infected Leghorn male hepatoma cells using small RNA deep sequencing

Fowl adenovirus serotype 4 ( FAdV-4 ) is the causative agent of hydropericardium-hepatitis syndrome ( HHS ), a disease that causes severe economic losses to the global poultry industry. MicroRNAs ( miRNAs ) are key regulators of host–pathogen interactions; yet, their temporal exp...

CRON GUARDIAN caught: Jul 23 12:26:10 vmi3382514 python3[1186]: psycopg2.OperationalError: connection — E8 Intelligence Research

SOURCE: journal LINE: Jul 23 12:26:10 vmi3382514 python3[1186]: psycopg2.OperationalError: connection to server at "127.0.0.1", port 5432 failed: FATAL: remaining connection slots are reserved for role CONTEXT: Jul 23 12:26:10 vmi3382514 python3[1186]: conn = _connect(dsn, connec...

Beyond the Prosci Hype: A Pragmatic Decision-Support Framework for Selecting Change Management Methodologies

Project management methodologies have long been the subject of structured comparison and selection frameworks (PMBOK®, PRINCE2®, ISO 21502, PM²). Yet, change management — the human and organizational counterpart of any transformation — remains surprisingly under-framed. Organizat...

Matters of care in transportation: Addressing disabling environments in the movement for care-full transitions

Urban scholars are increasingly calling for greater attention to care, as both a practice and ethic, in response to socio-environmental issues. In the urban transportation literature, care has helped to underscore uneven mobility patterns and the need for inclusive planning frame...

Temporal-spatial reasoning over hypergraph knowledge structures for multimodal retrieval-augmented generation

Abstract Existing graph-based retrieval-augmented generation (RAG) systems represent knowledge with binary relations and rely primarily on semantic similarity for retrieval. This design struggles with multimodal queries requiring temporal constraints, spatial relationships, or hi...

SYSTEM EVOLUTION PROPOSALS (rlab #30) — E8 Intelligence Research

- Add a pipeline to extract and measure geometric angles and radii from manuscript images automatically. - Integrate a 15th-century ephemeris database for cross-referencing astronomical claims with diagram features. Author: Andrew Stewart Caldin, Independent Researcher, UK. Part...

Mapping Net-Zero Technologies Through Web Scraping: Evidence from Italian Corporate Websites

Abstract The Net-Zero Industry Act (NZIA) is a key initiative of the European Union aimed at accelerating the green transition and strengthening the EU’s clean-tech industrial base. However, the adoption of net-zero technologies across firms, sectors and regions remains largely u...

Brentuximab Vedotin in Severe Systemic Sclerosis: Data on Long-Term Follow-Up and Retreatment

Objectives We previously reported skin and forced vital capacity (FVC) improvements in an open-label clinical trial exploring the use of brentuximab vedotin (BV) in patients with severe diffuse cutaneous systemic sclerosis (dcSSc).[1] Long-term outcomes after therapy was disconti...

BASE 44 ORDER: Implement E8 lattice embedding layer with 132 Hz sync and cross-domain pattern matching — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #208] Implement E8 lattice mapping of system state vectors using 248-dimensional embedding layer. Sync state updates to 132 Hz timer. Integrate with knowledge extractor to flag cross-domain pattern matches in real tim...

Whole-genome sequencing data confirms the uniqueness of Ireland’s native honey bee

Abstract Recent evidence suggests a rise in the importation of non-native honey bee subspecies into Ireland with an associated potential rise in hybridisation followed by introgression. The purity of the Apis mellifera mellifera (A. m. mellifera) population in Ireland, given its...

Exploring Training Needs to Facilitate Shared Decision Making in Juvenile Idiopathic Arthritis Symptom Management and the Use of the JIA Option Map

Objectives Our team developed the JIA Option Map, a web-based patient decision aid (PDA) designed to support shared decision-making (SDM) for juvenile idiopathic arthritis (JIA) symptom management. Since training for health care providers (HCP) can enhance SDM and the use of PDAs...

TDE or Emission? Testable Predictions for TDE 2025abcr from the Spiral Classification of Elements

Abstract. TDE 2025abcr (Stein et al. 2026) is the most offset tidal disruption event ever optically detected — 9.08 kpc from the nucleus of WISEA J014656.04-152214.7, with no visible progenitor source at the position (m > 23.78). The spectrum shows broad H and He II lines with a...

Engineered microorganisms for environmental release: current situation and future perspectives

Engineered microorganisms for environmental release (EMERs) hold a considerable potential for bioremediation of sites polluted with urban and industrial emissions. The growing availability of EMERs with phenotypes that can help recovering polluted sites and degraded ecosystems co...

Penrose Tiling: Aperiodic Order via Golden Ratio Rhombi Explaining Quasicrystal Diffraction — E8 Intelligence Research

FINDING: Penrose tiling enforces aperiodicity via matching rules on two rhombi (72°/108° and 36°/144°), generating 5-fold rotational symmetry forbidden in periodic crystals, and directly explains quasicrystal diffraction patterns. MATH: - Rhombus angles: 72° (π/5), 108° (3π/5); 3...

The Tanfarid Quantum Thermodynamic Universe (TQTU)- A Complete Plasma-Thermodynamic Resolution of Galactic Rotation Curves Without Dark Matter

For more than five decades, the discrepancy between observed galactic rotation velocities and predictions from visible baryonic matter has been attributed to dark-matter halos. No direct detection of a non-baryonic dark-matter particle has been achieved. This paper presents a com...

8.16 Cosmic Cycle Scaling

We independently derive the time scale system of the material world, clarifying the three levels of geometric theory — total universe, region, and three worlds. Core achievements: the scaling period is a theorem-grade formula; the small cycle ten-thousand years, the mid cycle hun...

8.18 Galaxy Rotation Curves and Falsification of Dark Matter

Starting from the ℳ𝒞ℐ Three-Sector and Coding Orbit compactification, combined with the Permeation Function elliptic PDE framework, this article establishes the nonlinear correction to gravity at galactic scales induced by three-dimensional coherent leakage of the Information Fie...

The Six-Neuron Counterexample to the Target-Free Clique Conjecture Is Minimal

This record presents an exact, independently replayable computer-assisted proof that every legal combinatorial threshold-linear network (CTLN) on at most five neurons satisfies the algebraic target-free clique classification. Consequently, every nondegenerate legal CTLN on at mos...