Research works

Discovery andCharacterization of RP04340 : A Highly Potent and OrallyActive Pan-KRAS PROTAC Degrader

Abstract Targeting diverse KRAS mutations with a single agent remains a significant challenge in oncology. Here, we report the discovery and characterization of RP04340, a potent and orally bioavailable pan-KRAS PROTAC degrader. Starting with a structure-based pan-KRAS inhibitor...

Mesoscale Simulation of Steel Slag Fine Aggregate Concrete Using a Cohesive Zone Model: Influence of Microparameters on Uniaxial Compressive Behavior

Abstract Steel slag fine aggregate (SSFA) concrete is a composite material comprising cement mortar, SSFA, coarse aggregate, and an interfacial transition zone (ITZ). To simulate the SSFA concrete’s uniaxial compression performance on the mesoscale this study applied Python in co...

Exact Closed-Form Solution for Fanno Flow of a Calorically Perfect Ideal Gas

Abstract This paper presents an explicit Lambert-W inversion of the classical Fanno relation for steady, adiabatic, quasi-one-dimensional flow of a calorically perfect ideal gas in a constant-area duct with wall friction. The formulation isolates the downstream Mach number as a f...

Nano MIPs (Molecularly Imprinted Polymers) Prepared From a “Frustrated” Gold Nanoparticle‐Based Pre‐Imprinting Matrix: Enhancing Binding Affinity and Selectivity

ABSTRACT Molecularly imprinted polymers have broad applications in chemistry and biology. Nanomaterials differ substantially from analogous materials on the macroscopic scale. In this work, ligand‐stabilized gold nanoparticles and two micelles with different surfactant structures...

Reproductive Tactics in Tropical Butterflies Love or Life: How do butterflies balance survival and reproduction?

<p><span style="font-size:11pt"><span style="line-height:115%"><span style="font-family:Arial,sans-serif"><b><span lang="EN" style="color:#01182d">Overview of Module: </span></b></span></span></span></p> <...

Tailoring Trilayer LiTa 2 PO 8 ‐Based Hybrid Solid Electrolytes to Enhance Interfacial Compatibility and Efficient Lithium Transport in Lithium Metal Batteries

ABSTRACT Herein, a spatially decoupled trilayer hybrid solid electrolyte (THSE) is designed through functional architecture engineering to simultaneously optimize ionic conduction and interfacial stability. THSE integrates a polymer matrix comprising a Li + ‐conductive LiTa 2 PO...

Experimental Investigation of Thermal Performance and Heat Transfer Enhancement in Microchannel Heat Sinks Using Hybrid Nanofluids

Microchannel heat sinks (MCHS) have emerged as pivotal thermal management solutions for high-power-density electronic devices, laser diodes, and aerospace systems. However, conventional cooling fluids such as water and ethylene glycol exhibit thermal conductivity, limiting their...

Sociodemographic bias in LLMs’ clinical decision-making for dizziness

Objective As large language models (LLMs) enter clinical decision support, concerns persist about sociodemographic bias. We assessed whether LLM recommendations for dizziness vary by patient descriptors and clinical detail. Methods We conducted a cross-randomized in-silico vignet...

Durable clinical and immunologic response to an off-the-shelf EWSR1–FLI1 peptide vaccine in metastatic Ewing sarcoma

Abstract Ewing sarcoma is a rare, fusion-driven malignancy with poor prognosis in the metastatic setting, for which no established immunotherapeutic treatment is currently available. Fusion breakpoints are rational precision immunotherapy targets, yet clinical evidence of immunog...

🧠 KNOWLEDGE EXTRACTED (rlab #101): 3 constants + 3 methods + 2 research topics + 3 improvements — E8 Intelligence Research

🧠 KNOWLEDGE EXTRACTED (rlab #101): 3 constants + 3 methods + 2 research topics + 3 improvements The single most valuable extraction is the method to test ancient undeciphered markings for E8 lattice alignment and phi-harmonic structure, which can falsify or confirm non-arbitrary...

SYSTEM EVOLUTION PROPOSALS (rlab #99) — E8 Intelligence Research

- Add a georeferencing pipeline to extract monument coordinates from historical plans (e.g., L'Enfant Plan) and current GIS data. - Implement an E8 projection module that can overlay 2D coordinate sets and compute node coincidence tolerance. - Create a phi-harmonic ratio scanner...

Association between long-term exposure to air pollution and blood pressure in children: an updated systematic review and meta-analysis

Abstract Introduction Ambient air pollution is a modifiable environmental exposure that may contribute to early cardiovascular risk. Although long-term exposure has been linked to blood pressure (BP) dysregulation, research on its effects in children remains limited, despite thei...

Experimental Investigation of Wear Behaviour and Mechanical Properties of Aluminium Hybrid Metal Matrix Composites Reinforced with SiC and Al₂O₃ Particles

This paper presents a comprehensive experimental investigation into the mechanical properties and tribological wear behaviour of Aluminium 6061 alloy-based hybrid metal matrix composites (MMC) reinforced with silicon carbide (SiC) and aluminium oxide (Al₂O₃) particles. Composites...

Multilevel bivariate analysis of childhood anemia and anthropometric failure among under-five children in sub-Saharan Africa

Abstract Childhood anemia and malnutrition remain critical public health challenges in Sub-Saharan Africa (SSA), with anemia affecting approximately 47.4% of preschool children globally. A cross sectional secondary data analysis from recent Demographic and Health Survey data was...

International Policy Framework for Donor Gonadal Tissue Banking and Transplantation: Advancing Endocrine Health, Healthspan and Responsible Reproductive Medicine

This policy concept proposes the architecture for a future international framework governing the donation, banking, cross-border transport and potential clinical application of donor ovarian and testicular tissue. Existing regulatory systems address human tissues and cells, trans...

Breaking of Off-Shell Degeneracy in Rank-2 Separable Three-Body Models: Gauge Invariance, Spectral Restructuring, and Ultraviolet Stability (Paper LXVIII)

We investigate three-body bound states in rank-2 separable Yamaguchi potentials with inter-channel mixing and establish three main results that clarify the nature of off-shell degeneracy in few-body systems. Building on our previous analysis of rank-1 separable models (Paper LXVI...

AI Data-Centre Water Tracker: an open, reproducible referee for data-centre water burden

AI disclosure: parts of this text were artificially generated with AI assistance and reviewed by the author. The models, and the conflicts they create, are named in the Conflict of interest section. An open, reproducible referee for the water burden of AI data centres. Ren et al....

The effect of cochlear implantation in older adults: an umbrella review of systematic reviews and meta-analyses

INTRODUCTION: Age-related hearing loss is increasingly prevalent and impacts psychosocial wellbeing, cognitive health, and quality of life in older adults. While cochlear implants (CIs) are effective for severe-to-profound loss, their use in the elderly was historically cautious....

Genetic links between IIIE iron meteorites and the core of the HED parent asteroid

Rocky planets formed through the differentiation of planetesimals into metal‑rich cores and silicate mantles, yet direct evidence linking these complementary reservoirs remains scarce. Here we show that IIIE irons and howardite-eucrite-diogenite (HED) meteorites are genetically l...

The Dependence of Articulation on Relation: A Preliminary Discussion of Being, Knowledge, and the Limits of Self-Representation

Generative Relational Being holds that beings are constituted in relation and that knowledge emerges from relational dynamics. Taken together these two commitments generate a difficulty the framework has not addressed. If knowledge emerges from relational dynamics, and a formal s...