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Mechanistic insights into cooperative permeation of glycerol and water through human aquaporin-10

Human aquaporins are integral membrane proteins that facilitate transmembrane transport of small molecules. Among the 13 members of this family, pH-regulated human aquaporin-10 (hAQP10) plays a critical role in glycerol metabolism and lipid homeostasis. A molecular-level understa...

Trace element accumulation in hooded crow nestlings: tissue- and age-specific patterns and implications for avian biomonitoring in riverine wetlands

Abstract Floodplain wetlands are dynamic ecosystems that may receive pollutants transported from upstream areas, but local exposure of wildlife to trace elements can vary depending on hydrology, bioavailability, habitat structure, and diet. In this study, we assessed the concentr...

An Ejector Refrigeration and Humidification–Dehumidification Desalination Hybrid System for Ceramic Industry Waste Heat Recovery: Performance Evaluation and Parametric Analysis

The sustainable development of the ceramics industry is severely impeded by its intensive energy consumption and the concomitant deficits in cooling and freshwater resources. To address these bottlenecks, this study proposes an integrated ejector refrigeration (ER)–humidification...

Operational Diagnosis and Data Suitability Assessment Using BMS and Smart-Meter Data in a Multi-Zone University Building

Aggregate building indicators can obscure substantial differences in electrical demand and thermal operation among monitored spaces. This case study examined 89 days of one-minute building management system (BMS) and smart-meter records from a multi-zone university building. Rout...

Knowledge-guided reinforcement learning for self-adaptive software engineering and multi-objective quality optimization

The current software engineering field is experiencing growing pressures due to the complexity of software systems, rapidly changing requirements, and high-quality expectations in a dynamic environment. Conventional development and quality assurance strategies are usually inflexi...

Cryo-EM structure of the bicarbonate receptor GPR30

G-protein-coupled receptor 30 (GPR30) is a bicarbonate receptor that plays a vital role in cellular responses to extracellular pH and ion homeostasis. Despite its significance, the mechanisms by which GPR30 interacts with bicarbonate ions remain elusive. There is no consensus on...

Weak Ridge-Flow Prior-Guided Fingerprint Reconstruction Under Severe Degradation

Fingerprint enhancement plays an important role in recovering identity-related ridge structures from degraded fingerprints. However, existing methods primarily focus on local texture restoration and may struggle to preserve ridge continuity and structural consistency under severe...

Aqueous Humor Proteomics Reveals the Molecular Basis for Differential Treatment Responses in nAMD and pmCNV

Purpose: Choroidal neovascularization (CNV) causes vision loss in neovascular age-related macular degeneration (nAMD) and pathologic myopia-related CNV (pmCNV). Despite shared clinical features, they respond differently to treatment. This study compared aqueous humor (AH) proteom...

Beyond the Nucleus: A Physical and Theoretical Analysis of the Fifth Dimension's Impact on Matter Stability and Nuclear Energy

This paper explores a theoretical framework examining the influence of a hypothetical fifth dimension on the stability of matter and nuclear energy dynamics. By integrating higher-dimensional concepts with nuclear physics principles, this study investigates how extra-dimensional...

Geochemical Effects of Groundwater Interaction with Steel Slag Aggregate Used in Road Construction

:This study assessed the effects of groundwater interacting with aggregate produced from steel slag, used as a ballast material in a waterproofing system protecting the road surface under high groundwater table conditions. Field investigations were carried out, with hydrochemical...

PRECISE-LLM: Formal Ambiguity Detection and Interpretation Enumeration for Text-to-SQL

Large language models translate natural-language questions into SQL with remarkable fluency, but they fail silently on ambiguous questions: rather than signalling uncertainty, the model commits to one reading and returns a syntactically perfect yet semantically wrong query. We pr...

A PHARMACEUTICAL AND ANALYTICAL STUDY ON DADRUHARA MALAHARA PREPARED WITH SOMRAJI TAILA

Background: Ayurvedic pharmaceutics includes various dosage forms intended for external application. Dadruhara Lepa is an external formulation used in the management of skin disorders, while Malahara Kalpana provides a semisolid dosage form suitable for convenient application and...

Synergistic Thermal Hazard Mitigation and Smoke Control by Water Mist and Semi-Transverse Mechanical Ventilation for Battery Electric Vehicle Fires in Road Tunnels

Battery electric vehicle (BEV) fires in road tunnels can intensify thermal, smoke transport, visibility, and CO exposure hazards under confined ventilation. This study evaluated the combined mitigation performance of water mist and semi-transverse mechanical ventilation. A three-...

Nonlinear Entropy–Enthalpy Correlation forMethane Adsorption on Shale

Abstract The enthalpy–entropy compensation effect is widely recognized in shale gas adsorption studies, where the standard adsorption entropy change is typically reported to vary linearly with the standard adsorption enthalpy change. However, this study reveals that such linear a...

Efficacy and safety of combined intravenous and topical tranexamic acid in primary total hip arthroplasty: a meta‑analysis and systematic review of randomized controlled trials

Both intravenous (IV) and topical tranexamic acid (TXA) reduce bleeding in total hip arthroplasty (THA), but the added benefit of combining the two routes and the potential modifying effect of topical dose remain unclear. We performed a systematic review and meta‑analysis of RCTs...

Value-Added Growth, Risk Exposure and Economic Sustainability in China’s Agriculture-Related Industries: An Ownership-Based Global Value Chain Analysis

Ensuring the sustainability of agriculture-related industries requires not only expanding value added but also maintaining stable value creation and adaptive capacity under changing economic conditions. This study examines the economic and organizational sustainability of China’s...

The Potential for "Needy" Socially Assistive Robots in Assisted Living: Support Workers' Perspectives

Amidst the mounting challenges posed by the ageing of worldwide populations, innovative care approaches need to be explored. Socially Assistive Robots (SARs) have emerged as a potential solution, however despite their potential benefits, they have yet to realise widespread utilis...

Ni/CeO2 catalysts incorporated with cassava-peel-derived biochar for CO2 methanation: Effects of biochar activation and impregnation route

Modifying highly active Ni/CeO 2 catalysts with less expensive materials whilst maintaining their catalytic activity is a challenging yet intriguing research direction. Herein, biochar was engineered from cassava peels and introduced into a Ni/CeO 2 -based catalyst for methanatio...

Optimization of Land Pattern in Mining Area Based on the Improvement of Ecosystem Service Function—A Case Study of Fushun Mining Area

ABSTRACT Mining activities are prevalent worldwide and pose significant threats to the supply of ecosystem services (ESs) for humanity. Many mining areas face challenges related to recovery and reclamation following resource depletion. A key challenge for the sustainable developm...