Research works

LAB #1028 NEUTRAL: TG AUTO: BASE 44 ORDER: Build breakthrough_e8_cache table and E8 hash function with LLM caching — E8 Intelligence Research

IDEA: AUTO-FORWARDED from the Telegram/breakthrough stream (#646569, division=platform, agent=andrew_base44): Andrew's order (Base 44 console): [SELF-BUILD from enhancement #1100] Create `breakthrough_e8_cache` table with columns specified. Implement Python E8 hash function using...

Critical Line Convexity: The Zeta-Gravity Metric and Geometric Structure of Zeta Zero Loci 临界线凸性与 ζ 引力度规:黎曼 ζ 函数的算术几何场理论

Abstract This paper puts forward a novel geometric framework centered on the Zeta-Gravity Metric to systematically investigate the distribution of non-trivial zeros of the Riemann zeta function. Two core discoveries are established: first, the Critical Line Convexity (CLC) proper...

Comparison of the active cycle breathing technique with other self-administered breathing techniques for the management of mucociliary production in cystic fibrosis: A systematic review

Background Cystic fibrosis (CF) is characterized by excessive airway mucus, recurrent infections, impaired ventilation, and progressive decline in lung function. Airway clearance techniques are central to management. Among them is the active cycle of breathing technique (ACBT), w...

Into the Bermuda Triangle: How Prime Ministers Fall

ABSTRACT Eleven years after David Cameron promised ‘stability and strong government’; nine years after Theresa May pledged ‘strong and stable leadership’; and two years after Keir Starmer vowed to ‘stop the chaos’, the UK has its seventh prime minister in a decade. Most analyses...

A Data‐Driven Review of Geoscience Research Evolution Using SciBERT ‐Based Topic and Network Analysis

ABSTRACT This review provides a data‐driven synthesis of the evolution of geoscience research from 2004 to 2023. A field‐level bibliometric overview of 439,680 records indexed in the Web of Science Core Collection (Geosciences, Multidisciplinary) characterises broad publication p...

Clinical Outcomes Following Transition from ICS/LABA to Single-Inhaler Triple Therapy in Patients with Uncontrolled Asthma: A Real-World Cohort Study

Background and Objectives: A considerable proportion of patients with asthma remain inadequately controlled despite treatment with inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) therapy. Single-inhaler triple therapy comprising an inhaled corticosteroid, a long-acting β...

Kinship Terms and Person Address in the English‐Speaking Sri Lankan Tamil Diaspora

ABSTRACT This article examines the impact of migration, globalization and digitalization on the use of nominal address terms in the English‐speaking Sri Lankan Tamil (SLT) diaspora community by undertaking a corpus analysis of English fiction authored by diaspora members with SLT...

Closed-loop blow forming: direct reuse of trimming scrap for new component manufacture

Abstract In this work, the direct reuse of scrap from the addendum region of previously blow-formed aluminium sheets to manufacture smaller components through a secondary forming step was studied. Numerical simulations and experimental tests were conducted to assess the feasibili...

BODIPY-Integrated Porous Materials: Design Principles, Functional Architectures, and Emerging Applications

Abstract The incorporation of functional organic chromophores into porous architectures has emerged as a powerful strategy to bridge molecular photophysics with materials-level performance. Among these, boron-dipyrromethene (BODIPY) derivatives offer a unique combination of stron...

Catalyst-FreeThiol–yne Nucleophilic PhotoclickChemistry

Abstract X-yne nucleophilic addition reactions are essential and powerful tools in a range of synthetic routes for realizing functional and stimuli-responsive materials. Unfortunately, the lack of spatiotemporal control and the requirement for catalyst addition in these reactions...

An open-source FPGA control architecture for solid-state spin-photon interfaces

Scalable quantum networks require quantum interfaces that coherently connect stationary matter qubits with flying photonic qubits. In solid-state defect platforms, such interfaces require coordinated optical excitation, microwave spin control, photon detection, and feedback with...

Compensation-Balanced Recurrent Neural Architecture Based on Nonlinear Spiking Neural Membrane Systems

Nonlinear Spiking Neural P (NSNP) systems offer a biologically inspired framework for modeling nonlinear temporal dynamics via spike consumption and generation. Existing NSNP-based recurrent architectures, such as the long short-term memory model inspired from spiking neural P sy...

Modular Arithmetic: From Cryptography to Spectral Geometry via Arithmetic Lattices — E8 Intelligence Research

FINDING: Modular arithmetic is a foundational tool in cryptography and number theory, with applications extending to Diophantine equations and spectral geometry via arithmetic lattices. | MATH: Congruence relation: \(a \equiv b \pmod{n}\) means \(n \mid (a - b)\). Key operations:...

FOXA2 Transcriptionally Activates SIRT1 to Inhibit Cochlear Ferroptosis in Noise-Induced Hearing Loss

Background: Noise-induced hearing loss (NIHL) is a pervasive occupational health challenge, yet the individual susceptibility mechanisms remain unclear. Ferroptosis, an iron-dependent form of programmed cell death, has been implicated in cochlear hair cell damage. This study aims...

Dopaminergic modulation of social reward anticipation in depression: neural effects of amisulpride versus placebo

Abstract Reward processing deficits are a well-established mechanism underlying anhedonia, a core symptom of Major Depressive Disorder (MDD). Given the role of dopamine in mesocorticolimbic reward pathways, this study examined whether a single low dose of amisulpride (100 mg), wh...

Construction of In Vitro-In Vivo Correlation (IVIVC) Degradation Evaluation Model of Absorbable PCL/β-TCP Alveolar Bone Repair Scaffold and Exploration of a Biosafety Evaluation Idea Based on “Homeostasis”

Abstract Traditional in vivo degradation assessments for resorbable medical devices face challenges due to extreme durations, high costs, and a lack of criteria for reaching tissue-response steady states. This study investigates a 3D-printed PCL/β-TCP bone grafting scaffold by de...

AI-Guided Discoveryof Natural-Product-Inspired Scaffoldsas Dual P-gp/BCRP Inhibitors to Overcome Cancer Multidrug Resistance

Abstract ATP-binding cassette (ABC) transporters ABCB1/P-glycoprotein (P-gp) and ABCG2/breast cancer resistance protein (BCRP) drive multidrug resistance (MDR) by limiting intracellular chemotherapy accumulation, and are coexpressed in cancers with overlapping substrates. Here, w...

Agricultural Producer Adaptation to Climate Change in Saskatchewan, Canada: Size Matters—but Most Importantly Cash Flow

An ethnographic study employing 72 qualitative interviews with agricultural producers and associated water decision-makers concerning farm climate change adaptation in Saskatchewan, Canada concludes that farm size matters. Inductively we established a distinction of 2025 hectares...

RTGNet: A Dual-Branch Network Integrating Recurrent Texture and Temporal Dynamics from sEMG for Lower-Limb Joint Angle Prediction

Accurate continuous prediction of lower-limb joint angles from surface electromyography (sEMG) remains challenging because of the nonlinear, non-stationary, and subject-specific nature of sEMG signals, which can reduce robustness and lead to degraded prediction accuracy during hi...

Infrastructural solidarity and informal continuing education: social purpose and critical equity in rural Indonesian teacher learning

Participation in lifelong learning is increasingly expected across contemporary societies; institutional provision, however, routinely fails practitioners in under-resourced, geographically isolated, and non-Western contexts. This study investigates how early childhood teachers i...