Research works

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

Transcriptome derived microsatellite markers in Valeriana clarionifolia reveal transferability among Patagonian Valeriana species

Abstract Several species within the genus Valeriana are globally recognized for their medicinal properties. However, their increasing economic value has led to overharvesting of natural populations, posing a serious threat to their long-term sustainability. Effective strategies f...

Does the Galactic Acceleration Scale Track H(z)? A direct comparison of the a₀–H coincidence with the first measurements of RAR evolution

The galactic acceleration scale a₀ ≈ 1.2 × 10⁻¹⁰ m s⁻² numerically satisfies a₀ ≈ cH₀/2π to within ~10%, a coincidence noted since Milgrom (1983) and still unexplained. Milgrom has long drawn the consequence: if the link is to the expansion rate rather than to Λ alone, a₀ is not...

Artificial Intelligence as a Competitive Equaliser for Mid-Sized Retailers: An AI Adoption Framework for StyleHub

Mid-sized retailers increasingly compete against e-commerce platforms that offer large-scale personalisation, predictive supply chains, and adaptive marketing at a cost smaller firms cannot easily match. This paper develops an artificial intelligence (AI) adoption framework for a...

Asymptotic su(2)-Isotropy of the Effective Quadratic Form and the Identification AH = 2

Papers Q7 Q9 of the Cosmochrony spectral geometry programme establish that the effective operator $L_{\mathrm{eff}}$ on $\mathbb{R}_\tau \times {\operatorname{Heis}}_3(\mathbb{R})$ has a principal symbol $\sigma_2(L_{\mathrm{eff}})|_{H_{\mathrm{eff}}} = A_H(k_X^2+k_Y^2) + A_Z k_Z...

The Testimonium Flavianum in Four Transmission Lines: Greek, Latin, Arabic, and Syriac

The passage on Jesus in Jewish Antiquities 18.63–64 survives in a Greek manuscript tradition thatis textually uniform and, for that reason, evidentially thin: every extant Greek witness descendsfrom a text already mediated by fourth-century Christian transmission. This article ar...

Unbounded Sign-Change Excess in Derivatives of the Riemann–Jacobi Kernel

This preprint studies the real-zero geometry of the derivatives of the standard Riemann–Jacobi kernel associated with the Riemann Xi function. The main result shows that every failure of the derivative Laguerre inequality at the symmetry point forces two additional sign changes b...

Near-infrared spectroscopic analysis of diesel properties based on back propagation neural network optimized by a hybrid genetic algorithm-particle swarm optimization algorithm

Rapid determination of the physico-chemical properties of diesel is of significant importance for both refinery production and environmental protection. To address the time-consuming nature of traditional chemical analysis and the tendency of back propagation neural networks (BPN...

Peripheral blood transcriptomic signature is associated with cognitive impairment and freezing of gait in Parkinson’s disease: a data-driven approach

Abstract Parkinson’s disease (PD) is a heterogeneous neurodegenerative disorder with variable long-term outcomes. Blood-based biomarkers for prognostic prediction remain underdeveloped. We aimed to develop a peripheral blood transcriptomic signature for predicting long-term compl...

Isolation, genomic characterization, and biocontrol potential of a bacteriophage cocktail against Staphylococcus aureus in milk

The objectives of this study were to isolate, characterize, and evaluate the biocontrol potential of Staphylococcus aureus -targeting bacteriophages in milk. From wastewater and raw milk samples, a total of 19 lytic phages were isolated. Among them SAKAY1298 and SAKAY1306 phages...

The Alphabet from the Sky: a documented construction

The Sefer Yetzirah, Sefer Raziel, and Gaffarel (1629) state that the twenty-two Hebrew letters were forged from the sky (3 mothers / 7 doubles / 12 simples = 3 axes / 7 wanderers / 12 signs) and that the ancients read the heavens as a text of letters. The computation verifies tha...

Finite Element Simulation of Dimensional Shrinkage and Residual Stresses in Material Extrusion of a Highly Filled Metal-Polymer Feedstock (17-4PH)

This preprint presents a staged thermo-mechanical finite element model of the printing, cooling, and detachment stages of material extrusion (MEX) for a highly filled 17-4PH stainless-steel feedstock (95.5 wt.% metal loading, paraffin-wax/stearic-acid binder). Extending the seque...

Narrative Identity and the Historical Subject: Ricoeur, Lévinas, and the Jesus of the Gospels

Ricoeur’s account of narrative identity has become the standard instrument for reading the Gospelsas texts that constitute a self and address a reader. This article argues that the instrument is soundand that its most common application is not, because that application turns on a...

Ring Contractionof Bicyclic Lactams: A MolecularEditing Aza-Favorski-Type Approach to Tetrahydroquinoline-2-carboxylicAcids

Abstract Development of skeletal editing methods offers new horizons for the acceleration of drug discovery. An original aza-Favorski-type approach is described for the ring contraction of benzazepine-2-ones, providing versatile tetrahydroquinoline-2-carboxylic acids. The sequenc...

MindForm — Cognitive Patterns: A Stateless Interpretive Layer for Experience-Driven Personality in LLM Agents

The two preceding papers in this series document personality as state: a temperament and trait vector a character is born with, and the values, moral outlook, beliefs and habits they earn by living. Both described a feedback loop in which that state colors how future experience i...

MXene-Induced Adsorption of Transition Metals Stabilizes Lithium-Rich Manganese Cathodes against Voltage and Capacity Decay

Abstract Lithium-rich manganese-based materials (LRMO) have emerged as ideal cathode materials for high-energy-density lithium-ion batteries due to their high capacity (>250 mAh/g) and low cost. However, the continuous migration and dissolution of transition metal ions (TM...

Iterated Functional Analysis, Volume I: Functional Levels, Quotient Shadows, Operator Theories, and Reconstruction Towers

This volume develops a typed framework for iterated functional analysis that distinguishes four mathematically different constructions: higher-order differentiation on a fixed state space, genuine functional levels whose elements act on lower-level functionals, invariant quotient...

Donor‐induced conformational gating and substrate‐assisted catalysis in α ‐1,3‐galactosyltransferase

Retaining glycosyltransferases catalyze the formation of stereochemically conserved glycosidic bonds through mechanisms that remain debated. Using bovine α1,3-galactosyltransferase (α3GalT) as a model, we combine mutagenesis, equilibrium unfolding, kinetics, and molecular dynamic...

Development of Geographic Information System-Driven Security Command and Control System for Enhancing Emergency Response and Community Safety in Kwara State

This paper examined the development of a Geographic Information System (GIS)-driven Security Command and Control framework to enhance emergency response and community safety in Kwara State, Nigeria. Using a convergent mixed-methods design, data were collected from 387 security pe...

BASE 44 ORDER: Implement torsion cache table with FNV-1a hashing and systemd timer — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #1114] Add breakthrough_torsion_cache table. Compute FNV-1a hash of title+content, multiply by 1.618 mod 2^64. Upsert on insert/update. Wrap LLM lookup with decorator checking cache. Set systemd timer for vacuum/reind...