Research works

Yiqi Huoxue Compound promotes neuroprotection against ischemic stroke by inhibiting apoptosis through the activation of PI3K/AKT pathway

Yiqi Huoxue Compound (YQHX), a traditional Chinese medicine formulation, has demonstrated therapeutic potential for ischemic stroke (IS). However, its underlying mechanisms are not fully understood. This study aimed to elucidate the neuroprotective effects and mechanisms of YQHX...

Adaptive Design Reasoning of Pre-Service Mathematics Teachers in Instructional Materials Design: A Conjecture Mapping Study

The sustainability of education systems depends on teachers’ capacity to adapt to changing curriculum expectations and diverse student needs. However, there is limited information on how adaptive design reasoning develops in the iterative process of designing and adapting instruc...

Contrasting population genetic structures of freshwater eels ( Anguilla marmorata, A. bicolor, A. mossambica ) from Madagascar

Abstract Freshwater eels (genus Anguilla ) are of major biological and commercial interest due to their complex catadromous life cycle and as a high‐value fishery resource, but the biology of tropical species is still poorly understood. This study investigates the genetic integri...

The Marginalisation of Charitable Functions: Confessional Argumentation and the Construction of the Diaconate in a Late Nineteenth-Century Catholic Encyclopaedia

Abstract This article examines how a late nineteenth-century Catholic account of the diaconate was shaped through selective emphasis and omission. Focusing on the 1882 encyclopaedia entry Diakon in the Real-Encyklopädie der christlichen Alterthümer , it treats the text as a case...

Characterization of pulmonary embolism events in patients with suspected pneumonia

Abstract Pneumonia and pulmonary embolism (PE) share similar clinical presentations, posing a significant diagnostic challenge. We investigated whether available diagnostic modalities could identify distinct characteristics in patients suspected of pneumonia later diagnosed with...

Education about gender development predicts support for transgender youth’s gender identity autonomy

Most adults have limited understanding of child development, yet their perceptions of development influence their decisions about whether to support children’s autonomy—such as support for autonomy-limiting anti-transgender legislation. This work found that adult participants bel...

A 9 + 1 multi-agent collaborative teaching model for clinical reasoning: integrating large language models into medical education

Clinical reasoning—the cognitive and metacognitive processes through which clinicians collect and interpret patient information, generate and test diagnostic hypotheses, and make clinical decisions—is a core competency in medical education. Since 1956, clinical educators have inn...

Thoracic ligamentum flavum ossification causing progressive myelopathy: a case report

Background: Ossified ligamentum flavum (OLF) in the thoracic segments is a rare but significant cause of progressive myelopathy characterized by spinal canal stenosis. While OLF is commonly reported in East Asian populations, it remains under-recognized in other regions, includin...

Immunotherapeutic targeting of calreticulin mutant myeloproliferative neoplasms

Abstract Calreticulin (CALR) frameshift mutations drive the majority of JAK2 / MPL -wild-type cases of essential thrombocythemia and myelofibrosis, producing a shared novel C-terminus that activates the thrombopoietin receptor and leads to constitutive Janus kinase (JAK)/signal t...

Artificial intelligence in nanotechnology: current applications and future perspectives

Abstract The convergence of artificial intelligence (AI) and nanotechnology has substantially transformed the discovery, design, synthesis, characterization and biomedical application of nanomaterials. This review provides a structured overview of AI applications in nanotechnolog...

Strontium Varied Across the City: 87 Sr/ 86 Sr Values at Ur (Tell al-Muqayyar, Iraq)

Analyses of isotope ratios provide researchers with evidence of past and present environments, ecologies, diets and more. For isotope analyses to be maximally effective, however, multiple forms of baseline knowledge need to be gathered. This paper contributes to filling key gaps...

Scaling Social Impact at Tony's Chocolonely: How Interactional Dynamics Shape Social Innovation Processes and Drive Institutional Change

Abstract Social enterprises are frontrunners in social innovation, yet our understanding of how they can scale their social impact beyond local, contained contexts remains nascent. To transform the institutional environment that gives rise to social problems, social enterprises m...

Transcriptomic profiling of inner ear hair cell spontaneous regeneration reveals the key role of dlx5a

Sensory hair cells (HCs) are susceptible to damage, typically causing permanent hearing and balance deficits in mammals due to limited regeneration. Understanding spontaneous regeneration in non-mammalian models offers key insights for restoring sensory function. Here, we establi...

Lead‐Associated Superior Vena Cava Syndrome: Diagnostic Delay and the Role of Invasive Pressure Measurements

ABSTRACT Superior vena cava (SVC) syndrome is an uncommon complication of transvenous cardiac device leads. Diagnosis may be challenging due to gradually developing and nonspecific symptoms. Furthermore, anatomical imaging does not always reflect the hemodynamic significance of v...

Measurable Coupling: Figures of Merit for Relationships Between Engineered Systems and Their Environments

A prior position paper proposed that measurable relationships between engineered systems and the elements and environments with which they interact be treated as explicit objects of engineering design, and identified two results as the natural first tests of whether that proposal...

Mechanical Properties and Earthquake Response Analysis of Seismic Isolation Bearing with Displacement-Restraining Device

Traditional lead rubber bearings (LRB) often fail under strong earthquakes due to excessive horizontal displacement of the isolation layer, which is caused by the lack of a synchronous displacement limiting mechanism. To address this issue, this study proposes a novel Displacemen...

Omni-Resonance Engine (ORE): Phase-Locking Kuramoto Dynamics in Sub-Billion Parameter Models for High-Fidelity COGNITIVE Reasoning

The prevailing paradigm in natural language processing relies heavily on aggressively scaling parameter counts in Transformer architectures to achieve emergent reasoning capabilities. This brute-force scaling inherently limits the deployment of advanced AI in privacy-critical, re...

World Models for AI Planning: Current State and Gaps Between Research and Deployment

Research article: World Models for AI Planning: Current State and Gaps Between Research and Deployment

Mesoporous LiMn1–xMxPO4 (M = Ni, Co) Precatalysts by Alcohol-Mediated Self-Assembly: Hydroxide Reconstruction and Suppression of Manganese Degradation for Stable Alkaline Oxygen Evolution

Abstract Manganese is an earth-abundant, low-cost transition metal with considerable potential for sustainable electrocatalysis; however, its poor stability under oxidative alkaline conditions remains a major challenge. Herein, we report the fabrication of Ni(II)- and Co(II)-subs...

Sources and sinks of dissolved oxygen in eutrophic tropical earthen fishponds

Dissolved oxygen is the main limiting factor in pond aquaculture production, yet the relative contributions of its various sources and sinks remain poorly quantified in eutrophic earthen pond systems. Photosynthetic oxygen production, surface exchange, sediment oxygen demand and...