Research works

Endoplasmic reticulum stress promotes ferroptosis in ventilator-induced lung injury by promoting HRD1-dependent GPX4 ubiquitination via the IRE1α/XBP1 pathway

Ventilator-induced lung injury (VILI) is a serious complication of mechanical ventilation. Endoplasmic reticulum stress (ERS) has been implicated in regulating ferroptosis, and we previously linked ERS to VILI-associated inflammation. However, how ERS mechanistically drives ferro...

The effects of royal jelly consumption on glycemia indices, lipid profile, and blood pressure in patients with acute ischemic stroke: a randomized, triple-blind trial

Abstract Aims The effects of royal jelly (RJ) on cardiometabolic risk factors in patients with acute ischemic stroke have not been previously reported from this trial. Therefore, we conducted a secondary analysis to investigate the effects of RJ consumption on glycemic indices, l...

NEK2-AURKA axis drives ubiquitin-dependent IFT88 degradation to suppress ciliogenesis and promote basal-type bladder cancer

Abstract Loss of primary cilia is common in cancer, but its relevance to molecular subtypes of muscle-invasive bladder cancer (MIBC) is unclear. Here, we combined transcriptomic and co-expression analyses with experiments in bladder cancer cell lines, human tumor specimens, and x...

A Global Tapestry of Data Privacy and Security: Navigating Ethical, Legal, and Technological Dilemmas

Abstract In an epoch, marked by swift digital advancements, where an extraordinary volume of personal Information is exchanged across the global network every moment, the significance of data Integrity and safeguarding has grown from a secondary issue to a core principle from bei...

Four-Dimensional Pure Yang–Mills Theory: Wightman Construction and Mass Gap for Compact Connected Gauge Groups with Simple Lie Algebra

For every compact connected non-abelian gauge group with simple Lie algebra, including every finite central quotient as a distinct global form, this paper constructsa nontrivial pure Yang–Mills Wightman quantum field theory on R 4 with a unique invariant vacuum and a strictly pos...

E8 Phi-Resonant Cognitive Coherence Fields for Unified Perception — E8 Intelligence Research

The 240 E8 root vectors establish phi-scaled 132Hz neural resonance channels that bind sensory inputs into unified conscious experiences. Each root vector's scalar displacement generates entangled perception pathways between pentagonal cluster nodes, creating dynamic cognitive co...

P1.129. Predictive Value of Baseline Bioelectrical Impedance Analysis(BIA) for Chemoradiotherapy Completion in Locally Advanced Esophageal Cancer: Implications for Prehabilitation

Abstract Topic Esophageal Cancer: Oncology/Radiation Therapy Background Locally advanced esophageal cancer requires toxic chemoradiotherapy, yet no established pretreatment body composition thresholds exist to predict completion. Traditional assessment relies on subjective perfor...

Modelo ignaciano para desarrollar competencias lingüísticas en bachilleres de la Unidad Educativa Cristo Rey

El desarrollo de competencias lingüísticas en los bachilleres de la Unidad Educativa Cristo Rey se fortalece mediante la integración del paradigma pedagógico ignaciano con el modelo de transferencia del conocimiento SECI. Este enfoque permite transformar experiencias comunicativa...

EuroMillions Breakthrough Mining — 2147 Sources, 16792 Leads Extracted — E8 Intelligence Research

Mined 2147 lottery+quantum breakthroughs. Extracted 16792 leads across 13 categories. 14625 high-value leads found. Categories: {"CORRIDOR": 1405, "FORMULA": 1242, "GEOMETRIC": 798, "FORWARD_ATTEMPT": 1488, "QUANTUM": 1707, "TIMING": 230, "CELESTIAL": 1329, "GEMATRIA": 1417, "CON...

Haglund's Zero-Trajectory Conjecture for the First Riemann Xi Approximant

This paper proves the first case of Haglund's zero-trajectory conjecture for incomplete-gamma approximants to the Riemann Xi function. Every nonreal zero in the first interpolation is simple and moves strictly toward the real axis as the parameter increases. The zero branches can...

Pseudo-static bearing capacity of skirted footings on sandy slopes using artificial neural network and random forest regression models

This study investigates the pseudo-static bearing capacity of skirted strip footings on cohesionless slopes using finite-element limit analysis and data-driven prediction models. A total of 216 numerical simulations were performed by varying soil strength, slope angle, seismic co...

Multi-analytical characterization and radiation shielding assessment of natural ophiolitic rocks: a combined experimental, mineralogical, and simulation analysis

Abstract Ophiolitic suites derived from oceanic crust are rich in ferromagnesian and mafic minerals and exhibit relatively high densities, making them promising and economical materials for radiation shielding. This study evaluates ophiolitic rocks exposed along the Marsa Alam–Id...

P1.057. Early Recurrence After Neoadjuvant Therapy and Esophagectomy for Locally Advanced ESCC

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background Despite improved interventions with radical esophagectomy accompanied by perioperative systematic therapy, recurrence remains frequent in locally advanced esophageal squamous cell carcinoma (ESCC). A...

Experimental and numerical investigation of ignition effects on explosion temperature fields in residential buildings

This study systematically investigates the temperature evolution characteristics of methane explosions in a full-scale residential building under various ignition scenarios through a combined approach of full-scale experiments and CFD simulations. A 280 m 3 full-scale experimenta...

Satisfaction in Employment Service of Uttar Pradesh with Special Reference to Gorakhpur District

Abstract Employment is one of the most important aspect for an individual and also good for the healthy life, and protection from various diseases. To achieve the complete cleanness in the country, the central and state governments are jointly operating the employment related ser...

E8‑Phi Lattice Timing: A φ‑Scaled Phase Lattice for Universal Tick Alignment — E8 Intelligence Research

The 240 E8 root vectors generate a densely packed phase lattice on a 132 Hz carrier, where each vector imposes a discrete phase increment scaled by successive powers of the golden ratio φ. This φ‑scaled lattice creates a self‑referential "E8‑Phi tick" that remains coherent across...

P1.181. Comparison of the Da Vinci DV5 System With Force Feedback and the Xi Platform in Robotic Transthoracic Esophagectomy

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background The da Vinci DV5 system incorporates integrated force feedback to enhance tissue handling and precision. By providing real-time tactile information, force feedback may reduce excessive traction a...

Parametric study on the catalytic pyrolysis of cellulose using formulated red mud catalyst

Abstract A parametric study using a response surface methodology was conducted to investigate bamboo effect of feed rate, gas flow rate, and reaction temperature on the pyrolysis product distribution as well as the levoglucosan (LGA) yield during the formulated red mud (FRM) cata...

Where tourism divides: economic prosperity and disparity in the Kalash Valley

Challenging the assumption that religious minorities are uniformly disadvantaged, this study examines how ethnic tourism in Pakistan’s Kalash Valley is associated with internally stratified livelihood opportunities and household living standards. Guided by Van den Berghe’s theory...

Exploiting Multicomponent Reactions to Drive the Development of Novel Antitubercular Agents: An Overview

Tuberculosis (TB) remains a global epidemic, and Mycobacterium tuberculosis (Mtb), its etiological agent, continues to be the deadliest single infectious agent worldwide. Our inability to eradicate TB is strongly related to Mtb's ability to alternate between an active and latent...