Research works

EMS response time and patient outcomes in high-acuity emergency responses: a Danish matched cohort study

Emergency medical services (EMS) provide prehospital care. To reduce response times, ambulances may use lights, sirens, and traffic exemptions, increasing risks for EMS personnel and other road users. Additionally, predefined response time targets may lead to inefficient resource...

Gut microbiota profile in school-aged children with vitamin A depletion and vitamin E deficiency: A cross-sectional study

Vitamin A (VitA) and vitamin E (VitE) deficiencies can result in significant health consequences in children. The role of the intestinal microbiota in these vitamin deficiencies has been scarcely explored. This cross-sectional study aimed to analyze the relationship of VitA deple...

Phi-Resonant Octonion Decomposition of E8 Root Vectors — E8 Intelligence Research

The 240 E8 root vectors decompose naturally into 8 octonion-dimensional layers where each layer's resonance frequency follows φ^n scaling from the 132Hz base, creating a Fibonacci-coherent harmonic lattice. The 344 Hz coherence phase transition emerges precisely at n=6 (132 × φ⁶...

Family Gatekeeping in Antenatal care Decision-Making: A Qualitative Study among Women in Rural Sangareddy District, Telangana, India

Abstract Background: Family members, particularly mothers-in-law and husbands, play crucial roles in maternal healthcare decisions in rural India. Understanding these dynamics is essential for designing effective maternal health interventions in Telangana, where maternal mortalit...

A Bilinear Residual Strength Model for Concrete Subjected to Fatigue Loads Based on Discrete Element Virtual Tests

Abstract Accurate assessment of fatigue residual strength is essential to ensure the safety and reliability of concrete structures given long-term fatigue loads. This study proposes a practical model for predicting concrete’s fatigue residual strength, which differs from conventi...

Rational Engineering of Carboxylic Acid Reductase for Improved Catalytic Efficiency and Substrate Tolerance Enabling Green Vanillin Biosynthesis

Abstract Vanillin is a high-value natural aromatic compound widely used in food, flavor, and pharmaceutical fields. Carboxylic acid reductase (CAR)-catalyzed vanillic acid bioreduction offers a green vanillin biosynthesis route, yet low catalytic activity and severe substrate inh...

Fluctuations of micronutrients during pregnancy in Lianyungang, Jiangsu, China: A prospective longitudinal cohort study

Pregnancy is accompanied by substantial physiological adaptations that may alter maternal micronutrient concentrations. A prospective longitudinal pregnancy-neonatal cohort of 51 healthy pregnant women was established at 6–8 weeks of gestation in Lianyungang, Jiangsu, China, conf...

Compartment-Specific Bacterial Communities and Their Functional Potential in the Desert Plant Citrullus colocynthis

Plants inhabiting arid and semi-arid ecosystems rely on their associated microbiota to withstand drought, heat, salinity, and nutrient limitation. We investigated the bacterial communities associated with the foliar tissues, roots, and rhizospheric soil of the desert plant Citrul...

Electoral reforms rejected: Partisan cues in an anti-party context

Proposals to change how parties functioned in elections appeared on several American states’ ballots in 2024, often bundling nonpartisan primaries (NPPs) with ranked choice voting (RCV). Given the complexity of the proposals, voters faced a difficult task and may have relied on c...

The effects of a lipid-based nutrient supplement intervention on DNA methylation in Bangladesh : insights from the Rang-Din Nutrition Study

Chronic undernutrition remains a major global health concern, particularly in early life. During this time, the resulting growth restriction and faltering are most responsive to nutrition interventions and consequential for health across the life course. Small-quantity lipid-base...

Clinical characteristics and outcome of a cohort of CLL patients with BTK T474 gatekeeper mutation

BTK T474 gatekeeper mutations confer resistance to both commercially approved covalent and non-covalent BTK inhibitors (BTKis) in chronic lymphocytic leukemia (CLL), yet their clinical implications remain poorly characterized. While pirtobrutinib was developed to overcome resista...

Prognostic Significance of Contrast Enhancement in Newly Diagnosed Grade 2 IDH-mutant Glioma

Abstract Background Contrast enhancement is generally considered an adverse prognostic feature in adult glioma. However, its significance in newly diagnosed grade 2 IDH-mutant glioma remains uncertain, with important implications for use of the mutant IDH inhibitor vorasidenib. W...

Cold-Water Immersion Does Not Improve Running Performance During Intensified Training.

The aim of this study was to investigate whether daily post-exercise cold-water immersion (CWI) preserves high-intensity running performance and modulates physiological and perceptual stress responses during an eleven-day intensified training period with limited recovery. Sevente...

Deconstruction of Hemp Stalks by Hydrated Deep Eutectic Solvents for Lignocellulosic Nanofibrils Preparation

Abstract The compact hemicellulose and lignin network in hemp stalks restricts fiber nanofibrillation and dispersion stability. Herein, a molecular simulation-guided hydrated deep eutectic solvent (H-DES) strategy was developed for biomass deconstruction and lignocellulosic nanof...

Comparing Human Gaze and Vision–Language Model Saliency Predictions in Safety-Relevant Scenes

Human visual attention plays an important role in how people perceive and respond to environments containing potential risks. It is unclear whether vision–language models (VLMs) can predict where people look in such scenes. This exploratory study compares human gaze with VLM sali...

The New Era of Metrology: What Lies Ahead for National Metrology Institutes?

This article examines the strategic implications of the 28th General Conference on Weights and Measures (CGPM) for the future of National Metrology Institutes. It focuses particularly on the digital transformation of the global metrology system and explores how developments such...

Gui Gan Shen Mai Yin attenuates cardiac hypertrophy and dysfunction in association with mitochondrial homeostasis and the PI3K/AKT1 signaling pathway

This study aimed to evaluate the effects of Gui Gan Shen Mai Yin (GGSMY) on cardiac hypertrophy and dysfunction and to explore associated mechanisms. The chemical profile of the GGSMY aqueous extract was characterized using UPLC-MS. Candidate active ingredients and potential targ...

A Flow-Field-Driven Zonal Framework for Mechanism-Based Corrosion-Hotspot Identification in Gas-Field Three-Phase Separators

Internal corrosion in gas-field separators is highly localized because flow, phase distribution, deposits, and water chemistry vary strongly over the vessel wall. This study presents a flow-field-driven zonal framework for corrosion-hotspot screening in horizontal three-phase sep...

Variable Selection for the Propensity Score Model: Beyond Main Effects and Linear Relations

ABSTRACT Propensity score methods are frequently used to estimate treatment effects in observational studies. The propensity score is usually estimated using a logistic regression model with additive and linear effects. The limited literature on variable selection for the propens...

The Evolution of Neoadjuvant Treatment for Resectable Esophageal Squamous Cell Carcinoma: Past Achievements, Current Standards, and Future Perspectives

Neoadjuvant treatment has become an integral component of multidisciplinary management for resectable esophageal squamous cell carcinoma (ESCC). Over recent decades, treatment has evolved from surgery alone to postoperative chemotherapy, neoadjuvant chemotherapy, intensified syst...