Research works

Safety and Effectiveness of Inebilizumab in Patients with Neuromyelitis Optica Spectrum Disorder: Interim Analysis of a Post-marketing Surveillance in Japan

Inebilizumab is used in Japan for relapse prevention in aquaporin-4 (AQP4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD). Nationwide post-marketing surveillance (PMS) is underway to evaluate the real-world safety and effectiveness of inebilizumab in Japanese pa...

Paliperidone-induced diabetes mellitus presenting with hyperosmolar hyperglycemic state: a case report

BACKGROUND: Second-generation antipsychotics (SGA) have been associated with adverse metabolic effects, including the development of diabetes mellitus (DM) and, in rare cases, life-threatening hyperglycemic emergencies such as diabetic ketoacidosis and hyperosmolar hyperglycemic...

The Answerability Calculus

Abstract The Answerability Calculus develops a general mathematical theory of Answerability as a constituted, typed relation and establishes laws governing its lawful transformation, resource representation, repair, composition, activation, obstruction and conservation. Its gover...

Machine Learning approaches for the detection of disease-causing variants in whole-genome data need to address the expression of functional genes

Gene-dosage combinations have been recognised as leading factors of disease. Given that those combinations may include dozens of genes, it is hypothesised that machine learning (ML) approaches may be useful in the classification of cases and controls and the identification of cau...

Who Are the Worst-Off? Objective, Subjective, and Preference-Based Approaches to Measure Older Adults’ Well-Being

Assessing the well-being of older adults requires a multidimensional framework, yet combining dimensions into a single summary measure raises conceptual and methodological challenges. This study examines whether objective, subjective, and preference-based aggregation strategies i...

Butter-Fat

Volume 29 Number 08 November 1951

Role of BSA adsorption in the evolution of polyimide coating performance

Polyimide (PI) encapsulation for implantable electronic devices (IEDs) must resist complex in vivo microenvironments, and its reliability directly determines device service life. However, existing PI coating research has focused primarily on single performance optimization, lacki...

The Psychoses : Jacques Lacan’s Seminar III (1955–1956)

SUMMARY During the academic year 1955–1956, Jacques Lacan, a prominent psychiatrist and psychoanalyst, delivered his third seminar in Paris. Seventy years later it remains little known among psychiatrists in the UK. Seminar III was devoted to the psychoses, particularly the delus...

Patient safety in hospital dentistry: A model for dentists without operating room privileges

A lack of compliance with professional privileging and training requirements is the most common cause of dental malpractice. In hospital dentistry, some dental specialties are trained to treat patients in the operating room, whereas others, including restorative dentists, endodon...

Cropland type shapes arbuscular mycorrhizal fungi (AMF) population density and species diversity in Northwest Ethiopia

AMF play critical function in soil fertility and plant nutrition, especially in absorption and translocation of immobile nutrients. Farm and soil fertility management activities enhance crop yield; however, they either positively or negatively impact the AMF population and divers...

The EU and the Western Balkans: soft securitization of enlargement during the initial stage of the Russia-Ukraine War of 2022

When the Russian armed forces launched a full-scale invasion of Ukraine on 24 February 2022, many politicians in Europe were alerted to the possibility of a spill-over of the war to the Western Balkans. Since the outbreak of the Donbas War in 2014, European states have swiftly re...

Neutrinos as Geometry Fragments

Neutrinos are not particles in any conventional sense. They don't have charge. They barely have mass. They pass through an entire light-year of lead with less than even odds of being stopped. Standard physics acknowledges all of this and then responds by giving them a spot in the...

High prevalence of Clonorchis sinensis infection with sex and age related patterns and comparative evaluation of four diagnostic techniques in Hengzhou, China

Abstract Background Guangxi is one of the regions where clonorchiasis is endemic, with Hengzhou City notably standing out as a high-burden area for Clonorchis sinensis ( C. sinensis ) infection. This study aims to evaluate the prevalence of C. sinensis infection and compare the p...

Impact of Plot Dimensions on the Sky-View Factor of a Residential Canyon in Indian Cities: A Parametric Analysis

Abstract Numerous studies have assessed the impact of urban canopy parameters on the urban heat island (UHI) effect. However, no tool is available to predict the UHI intensity in yet-to-be-developed urban areas. Nevertheless, development can be predicted by analyzing the applicab...

Butter-Fat

Volume 29 Number 01 April 1951

Robust Antiferroelectric Response in the Pbca Phase of Hafnium Zirconium Oxide via Aluminum Substitution

ABSTRACT Hafnium zirconium oxide (HZO) has attracted attention for applications in nonvolatile memory and energy harvesting devices. However, it faces practical challenges such as insufficient endurance. One promising strategy to address this limitation is the utilization of anti...

Greek versus English Degradation Under Consumer GGUF Quantization

Local inference of Large Language Models (LLMs) depends on quantization to trade accuracy for efficiency on consumer hardware. This trade-off is usually measured in English, raising the question of whether speakers of other languages (like Greek) suffer more with the same file —...

Integrated geophysical and hydrochemical assessment of groundwater in Samaro Tehsil, District Umerkot, Sindh, Pakistan

Groundwater is the primary source of drinking and irrigation water in the semi-arid region of Samaro Tehsil, District Umerkot, Sindh, Pakistan. However, the detailed information on aquifer geometry and groundwater quality has remained limited. In this study, the first integrated...

Biological age acceleration and mortality risk among U.S. adults with cardio-kidney-metabolic syndrome, stages 0–3

This study aims to evaluate the associations of Klemera-Doubal Method Biological Age Acceleration (KDM-BAA) and Phenotypic Age Acceleration (PAA) with all-cause and cause-specific mortality in U.S. adults with Cardio-Kidney-Metabolic (CKM) syndrome stages 0–3 and to establish ris...

The Prognostic Significance of Intracellular Glutathione and Extracellular Thiol-Disulfide Homeostasis Patients with Bladder Tumors

Objective: This research focused on evaluating the relationship between intracellular oxidized/reduced glutathione levels and extracellular thiol-disulfide parameters in patients with bladder cancer. Materials and Methods: This case-control studyinitially included 63 patients wit...