Research works

Determinants of treatment interruption among patients with multidrug-resistant tuberculosis in Addis Ababa using an unmatched case-control study

Multidrug-resistant tuberculosis (MDR-TB) requires prolonged, complex regimens frequently associated with substantial adverse effects, making treatment interruption a major barrier to successful outcomes. Interruption may increase the risk of mortality, acquired drug resistance,...

Analysis on influencing factors for temperature control of concrete surrounding spiral case of hydropower station

The spiral case and its surrounding concrete (SCSC) are critical structural components and primary load-bearing elements for hydropower generation, necessitating stringent safety and reliability measures. The SCSC is a mass concrete structure, with temperature control typically a...

An Analysis of Mobility Styles and Carsharing Adoption Intentions in Major Urban Areas of Japan: Evidence from Tokyo, Osaka, and Kanagawa

This study links mobility styles with carsharing intentions and next-generation vehicle preferences in urban Japan. An online survey of licensed drivers in Tokyo Metropolis, Kanagawa Prefecture, and Osaka Prefecture captured mode use frequencies and stated preferences by travel p...

Sustainable production of polyhydroxyalkanoates from agricultural wastes within a circular economy framework

The current environmental crisis associated with fossil fuel-based plastics has driven the search for sustainable alternatives, among which polyhydroxyalkanoates (PHA) emerge as promising biodegradable biopolymers. The present article provides a comprehensive review of the recent...

Understanding the determinants influencing middle-aged and elderly users’ continuous use intention of mobile news apps

This study aims to examine the determinants of middle-aged and older users’ continuous use intention toward mobile news apps. Based on the ECM and the UTAUT2, this study developed a theoretical model to explain users’ continuous use intention after adopting mobile news apps, whil...

Change of the burden of infectious diseases and antimicrobial resistance in India: a systematic analysis for the Global Burden of Disease Study 2019 and 2021

Infectious diseases and antimicrobial resistance (AMR) remain one of the major causes of mortality and disability in India. But age- and pathogen-specific evidence on recent changes in AMR burden is limited. We analysed India-specific data from the Global Burden of Disease Antimi...

Resilience and re-establishment of sulfide- and redox-structured microbial networks after holomixis in a meromictic lake

Land-locked meromictic lakes sustain persistent redox stratification that structures microbial niches and sulfur–nitrogen–carbon cycling. Whole-lake overturns are unusual in such systems, and the temporal dynamics of microbial community re-establishment and functional recovery du...

US adults’ initiation of lifestyle changes because of podcasts they listen to

Many US adults listen to podcasts. Podcasts are a flexible and low-cost digital resource for health promotion. To examine sociodemographic and podcast use characteristics associated with initiating lifestyle changes because of podcasts among US adults who listen to podcasts. We c...

Midwifery leaders’ views of the barriers and facilitators for implementing, sustaining and upscaling midwife-led continuity of care in Australia – a qualitative study

Problem Despite national and global recommendations, most pregnant women in Australia do not receive midwife-led continuity of care (MLCoC). Background MLCoC improves health outcomes, yet its implementation has been slow. Supportive leadership is essential for upscaling, and insi...

Glucocorticoids directly inhibit insulin biosynthesis via the glucocorticoid receptor in pancreatic β-cells

Glucocorticoids induce hyperglycemia by promoting hepatic gluconeogenesis and impairing insulin sensitivity in peripheral tissues. However, their direct effects on pancreatic β-cells remained poorly understood. This study investigated whether glucocorticoids directly impair insul...

Comparing demographic and neural-network-based representations of the black–white mortality hazard gap

Black–White disparities in U.S. mortality persist, but existing analyses may inherit a representational problem that I term inequitable error —socially patterned false-negative error that can obscure observed deaths among Black Americans even in the presence of significant averag...

Diverse microbial communities support multiple patterns of functional redundancy in tidal flats across the Chinese coastline

Tidal flats are critical transitional ecosystems in which microbial communities drive essential biogeochemical processes while adapting to strong environmental fluctuations. However, the mechanisms by which these communities maintain functional stability in highly dynamic tidal-f...

How AI enabled human resource management drives sustainable hybrid performance through AI centric green human resource management in Saudi Arabian private sector firms

This study examines the relationship between AI-enabled human resource management (HRM) and AI-centric Green HRM (GHRM) and how these capabilities influence sustainable hybrid performance, defined as the integration of productivity, adaptability, and environmentally responsible w...

Tomdok: a fully reproducible multi-engine consensus virtual screening pipeline with data-driven safety annotation, validated by blind recovery of clinically validated inhibitors

Background. Virtual screening campaigns are frequently irreproducible: fragmented toolchains,undocumented parameters and absent safety annotation impede reuse and independentverification. Methods. We present Tomdok, an open-source, one-command pipeline (stages 00-09) thatintegrat...

Disentangling the Number of Letters Effect and the Influence of Visual Crowding

We transferred the approach of Hautala et al. (2011) and Hautala & Loberg (2015) from Finnish to German to dissociate the confound word length components number of letters (NrL) and spatial width (SpW) inherent to the majority of reading research. The aim was to disentangle the N...

Autopsy of an N=1 Cybernetic Therapy: Deconstructing the Onkyo Protocol — Mechanisms, Efficacy, and Systemic Risks of Multimodal AI Digital Therapeutics

[Version 2 Update Summary] Version 2 represents a major theoretical and empirical overhaul based on open-science peer critique and autoethnographic maturation: Reframed Methodological Paradigm: Grounded strictly as an N=1 Autoethnography / Computational Phenomenology, explicitly...

Numerator or Denominator Decomposing the successive transitions of the screening length into two mechanisms: a public analysis protocol for existing data

Abstract The screening length can grow along two routes, a rise in transport capacity or a fall in local dissipation, and the two are fully separable observationally: the first is read from accessibility, the second from the relaxation curve of a disturbance. Every historical tra...

ASSAY: No Action Without a Prediction

ASSAY is a general agent harness built so that an LLM agent reasons its way through an unfamiliar world, learns that world from interaction at test time, and carries what it learns into later runs. A world is attached through one small adapter and a registry of permitted actions,...

Populism and academic freedom

Abstract Academic freedom empowers scholars to influence public discourse and debate, cultivate critical reasoning, discuss ideas that challenge traditional values, and impose a soft check and balance on governments. For those reasons, governments have specific preferences regard...

A counterexample to R-superlinear convergence of cyclic steepest descent

Cyclic steepest descent recomputes an exact steepest-descent stepsize once per cycle and reuses it for m updates. Dai's ICM 2022 survey states that this method is likely to converge R-superlinearly on n-dimensional convex quadratics when m is at least (n+1)/2. We show that the co...