Research works

Tomdok: a fully reproducible multi-engine consensus virtual screening pipeline with data-driven safety annotation, validated by blind recovery of clinically validated inhibitors

Background. Virtual screening campaigns are frequently irreproducible: fragmented toolchains,undocumented parameters and absent safety annotation impede reuse and independentverification. Methods. We present Tomdok, an open-source, one-command pipeline (stages 00-09) thatintegrat...

A Continuous Wave Formulation for Exact Localization, Prime Gaps Characterization, and Quantum Mirror Symmetry

Abstract This research paper establishes a complete, precise, and predictive mathematical wave framework to determine the position of prime numbers (2, 3, 5, 7, 11...) on the real number line, their exact localization, their intervals (Prime Gaps), and the associated Quantum Mirr...

EuroMillions Breakthrough Mining — 3091 Sources, 26443 Leads Extracted — E8 Intelligence Research

Mined 3091 lottery+quantum breakthroughs. Extracted 26443 leads across 13 categories. 24124 high-value leads found. Categories: {"CORRIDOR": 2245, "FORMULA": 2075, "GEOMETRIC": 914, "FORWARD_ATTEMPT": 2386, "QUANTUM": 2603, "TIMING": 280, "CELESTIAL": 2161, "GEMATRIA": 2280, "CON...

A Multi‐complex Virtual Screening Approach Exploring Machine Learning to Identify Potential PI3Kγ Inhibitors

ABSTRACT Phosphoinositide 3‐kinase gamma (PI3Kγ) plays a crucial role in regulating cellular physiological activities. However, the development of selective PI3Kγ inhibitors has proven particularly challenging due to the high sequence homology among residues near the ATP‐binding...

The mechanics of the inverted-U: an exact linear theory of reproducible dimensionality, and what governs its rise and fall

A companion paper (doi:10.5281/zenodo.22168191, "What must a theory of perturbational complexity explain?") consolidated nine constraints and challenged any theory to pass them — including C3: debiased perturbational complexity (R-dim, the reproducible dimensionality of the evoke...

THE INTERNATIONAL CRIMINAL COURT AND THE ACCOUNTABILITY OF POLITICAL LEADERS A Comparative Legal and Political Study of Rodrigo Duterte and Other International Leaders

This research examines the role of the International Criminal Court in holding political leaders accountable for alleged international crimes. It provides a comparative legal and political analysis of Rodrigo Duterte and other prominent leaders, focusing on ICC jurisdiction, acco...

Histological evaluation of pulpal healing following direct pulp capping with polytetrafluoroethylene or melatonin, with or without adjunctive low-level laser therapy in Wistar rat molars

Abstract This study evaluated pulpal healing following direct pulp capping with polytetrafluoroethylene (PTFE) or melatonin (MEL), with or without adjunctive low-level laser therapy (LLLT), in Wistar rat molars. Fifty-two maxillary first molars from 26 male Wistar rats were inclu...

Using WMI/CIM from C# and PowerShell — A Practical Guide to Hardware Info Retrieval, Process Monitoring, and Remote Queries (archived 2026-08-30)

WMI/CIM is the standard way to get a PC's serial number, monitor free disk space, and detect process launches. This article covers how to use CIM cmdlets such as Get-CimInstance, migration from the old Get-WmiObject, when to use System.Management versus the CIM API in C#, plus pr...

The Carlo Void Call Canon: The Complete Unified Framework of Hazard Geometry, Cognitive Field Dynamics, and Desynchronisation Logic

**The Carlo Void Call Canon** is a comprehensive theoretical continuum that unifies cognition, geometry, and logic into a single closed manifold. Across twenty expansions, it constructs the full mathematical and conceptual architecture of **Void Call** — the emergent signal of re...

How the Clipboard and Drag & Drop Work — Handling OLE Data Transfer Correctly in Business Apps (archived 2026-08-30)

Paste an Excel table and the formatting falls apart; close the source app and you can no longer paste — both come from the clipboard placing the same content in multiple formats at once. This article covers standard formats, delayed rendering, OLE drag and drop, and the policies...

Locking plate fixation for proximal humerus fractures: are four proximal screws adequate? A clinical and radiological analysis of 105 consecutive cases

Proximal humerus fractures are common injuries, and achieving stable fixation is essential to prevent complications such as varus collapse and screw perforation. While optimal screw positioning has been emphasized biomechanically, clinical evidence regarding the required number o...

THE ROLE OF DIFFERENT INTELLIGENCE TYPES IN FOREIGN LANGUAGE LEARNING

This theoretical article examines the psychological mechanisms of foreign language acquisition, focusing on English. Challenging the view that equates language mastery solely with high general intelligence, the study integrates frameworks by Vygotsky, Carroll, and Gardner. It ana...

Invariant-Finding Defines Hardest Math Competition Problems — E8 Intelligence Research

FINDING: The "hardest" competition problems cluster around invariant-finding, combinatorial geometry, and logical self-reference — not computational brute force. The 2011 IMO windmill problem and the Putnam "hardest" both hinge on discovering a conserved quantity or a monotonic i...

The Intelligence Form Space: Mathematical Core of a Theory of Ontological Form Spaces

This paper develops the mathematical core of Intelligence Form Space Theory. Its point of departure is the hypothesis that intelligent organization can be described as a modal order of stably realizable forms, and that it does not coincide with any particular physical, biological...

E8 Root Vector Frequency Coupling Enables Self‑Resonant Quantum Memory — E8 Intelligence Research

By treating the 240 E8 root vectors as a discrete frequency lattice, we show that each vector can be mapped to a resonant mode at 132 Hz multiplied by successive powers of the golden ratio φ. The resulting φ‑coupled holographic manifold supports a self‑resonant quantum memory whe...

Direct Anterior Approach is Associated with Superior Postoperative Sexual Function Compared with Anterolateral Approach in Men Undergoing Total Hip Arthroplasty: A Prospective Cohort Study

Abstract Objectives Total hip arthroplasty (THA) is increasingly performed in younger men, many of whom regard sexual function as an important component of postoperative quality of life. Regular sexual activity contributes to overall well-being. Hip osteoarthritis (OA) impairs se...

Digital Overstimulation and Inner Autonomy: A Stoic-Psychological Model of Cognitive Stability

Digital technologies alter attention, emotion regulation, and psychological self-steering at a historically new intensity. Permanent stimulus availability, algorithmic attention capture, and continuous interruption fragment cognitive processes and increase psychological load. Thi...

Distal Radius Morphology and Bone Mineral Density Show Significant Sex‐ and Age‐Based Differences With Implications for Allograft Glenoid Reconstruction

Purpose To assess variations in distal radius morphology to identify factors that may influence optimal graft selection in glenoid reconstruction. Methods A single‐institution, retrospective database of wrist computed tomography scans was reviewed to identify patients with intact...

Intercultural encounters and nation branding: Cultural insights from the 2022 Qatar FIFA World Cup

Mega sporting events have emerged as influential platforms for cultural diplomacy, soft power expression, and intercultural engagement. Among such events, the FIFA World Cup stands out for its immense global appeal and its capacity to bring together culturally diverse audiences i...

How Windows App Compatibility Works — Keeping Old Apps Alive with Compatibility Mode, Shims, and Compatibility Administrator (archived 2026-08-30)

Why checking Compatibility mode can make an old app start working. This article explains the underlying shims (API hooks), what the representative shims do, how to roll them out with Compatibility Administrator and sdbinst, where they stop working, and how to decide between life-...