Research works

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Latent profile analysis of benefit finding in maintenance hemodialysis patients and its association with treatment adherence

Abstract Maintenance hemodialysis (MHD) patients experience prominent negative emotions, and dialysis outcomes/prognosis rely heavily on treatment adherence. Few studies have explored the relationship between latent Benefit Finding (BF) categories and adherence. This study aims t...

Characterization of the Polysaccharide and Protein Composition of Neurospora crassa Conidium, Perithecium, and Ascospore Cell Walls

We carried out carbohydrate composition and carbohydrate linkage analyses on Neurospora crassa cell walls from vegetative hyphae, conidia (asexual spores), perithecia (female mating structures), and ascospores (sexual spores). We show that the composition and structure of the cel...

Organic Activatable Afterglow Imaging Probes: From Molecular Design to Biomedical Translation

ABSTRACT Organic activatable afterglow probes have developed into a distinct class of optical imaging tools. They allow for a temporal separation between signal emission and external irradiation, thereby enabling high‐contrast imaging. We have summarized the latest advances in th...

Improving Ventilation Performance in a Multi-Storey Solar Chimney System Using Neutral Plane Analysis: A CFD Case Study

Multi-storey solar chimneys are often evaluated using shaft-outlet airflow, which may conceal uneven airflow distribution among floors. A shaft may provide adequate extraction while upper floors receive insufficient air or experience reverse airflow. This study examined the relat...

Clinico-Hematological Evaluation of Bicytopenia in Adults: A Hospital-based Observational Study

BACKGROUND: Bicytopenia is defined as a reduction in any two of the three major blood cell lineages and may result from a wide spectrum of infectious, nutritional, hematological, and systemic disorders. Early identification of the underlying etiology is essential for appropriate...

Flexible Osmotic Energy Batteries Enabled by Stacked Bicontinuous‐Network Hydrogels

ABSTRACT Reverse dialysis based on hydrogel membranes holds promise for the development of soft electrochemical batteries. However, the energy conversion efficiency is often constrained by excessive swelling, which dilates nanochannels and degrades permselectivity. Here, we prese...

Damage-Quantified Reusability Evaluation of Reusable Launch Vehicle Avionics: A Framework Integrating Physics-of-Failure Modeling with Multi-Criteria Decision Making

Reusable launch vehicles (RLVs) subject avionics electronics to repeated vibration, shock, and thermal cycling, yet no standardized method exists to evaluate reusability at the device level. We integrate physics-of-failure models—Steinberg vibration fatigue, Engelmaier/Coffin–Man...

Digital platform capability and knowledge integration in large firms: a multi-case study of UK technology companies

Purpose Large firms invest heavily in digital platforms but struggle to govern information flows, integrate external knowledge, and convert infrastructure into enterprise innovation capability. This study aims to examine how UK technology firms build digital platform capability (...

Solanaceous-Vegetable Price Volatility and Producer Operating Income in China: Evidence from Three Production-Side Response Indicators

Solanaceous vegetables are fresh and perishable, are marketed in concentrated periods, and require production decisions to be made in advance; consequently, fluctuations in the price path can alter producers’ cash-flow arrangements, input schedules, and risk exposure. Using a bal...

Redefining reference materials for the evolving metabolomics landscape

Abstract The evolution of metabolomics, a field aimed at comprehensively measuring the small organic molecule composition of a biological matrix, fundamentally reshaped the landscape of analytical measurement reliability. The 2011 release of Standard Reference Material (SRM) 1950...

Food choices and beliefs in adults with inflammatory bowel disease in Sweden

Abstract Objectives Diet is a recognised risk factor for inflammatory bowel disease (IBD) and a management strategy. Concerns persist regarding the adverse effects of restrictive diets, including nutritional deficiencies and selective eating. The impact of IBD on patients’ belief...

Ship-radiated noise separation via auditory scene analysis-guided deep learning

Ship-radiated noise is an important acoustic source in passive underwater monitoring, but marine recordings often contain overlapping components from multiple sources, which can hinder target-related analysis. To address this problem, this paper develops a ship-radiated noise sep...

Far From Home? Accessing Everyday Places in Rural and Urban Communities

OBJECTIVES: Rural residents are believed to experience greater social isolation than their urban counterparts. This isolation is typically attributed to the structural conditions that distinguish rural communities from urban communities. In the present study, we direct attention...

Human Macrophage Polarization Dynamics on a 3D Fibrous Polydioxanone Mesh In Vitro

The host immune response plays a central role in determining biomaterial performance, particularly through early macrophage activation dynamics at the tissue–biomaterial interface. This study evaluated the response of THP-1-derived human macrophages cultured on a fibrous extracel...

A crossing theorem for CMB-distance-transparent dark-energy deformations

Cosmological distances constrain dark-energy evolution through weighted integrals of the expansion history. This paper isolates a sign-change consequence for deformations around a flat [Formula: see text]CDM background. Let [Formula: see text], with [Formula: see text] continuous...

Feasibility Study of Deep Learning-Driven Image Restoration for Fast, Low-Count [18F]FP-CIT Digital PET/CT

Background/Objectives: N-3-[18F]fluoropropyl-2β-carbomethoxy-3β-4-iodophenyl nortropane ([18F]FP-CIT) positron emission tomography/computed tomography (PET/CT) is an effective imaging tool for diagnosing parkinsonism. This study evaluated the feasibility of deep learning (DL)-dri...

Allograft and Recycled Autograft Reconstruction Following Resection of Bone Due to Osteosarcoma: A Systematic Review of Time to Union and Complications

Abstract Background: Osteosarcoma is the most common primary malignant bone tumor, predominantly affecting the femur, tibia, and humerus. Despite advances in surgical oncology, comprehensive evaluations of biological reconstruction methods remain limited, with existing literature...

Animal Individual Factors Dictate Learning Strategy: An Integrated Analysis of Cattle Adaptation to a Virtual Fencing System

Virtual fencing (VF) is a promising technology for pasture management, but its successful implementation depends on understanding the factors that influence the animal learning. The aim of the present study was to evaluate the significance of individual animal factors that affect...

DNA methylation either antagonizes or promotes Polycomb recruitment at transposable elements in Arabidopsis

Abstract Transposable elements (TEs) are usually silenced by DNA methylation and H3K9me2, but in the absence of DNA methylation they can instead acquire the Polycomb-associated mark H3K27me3. Here, we initially set out to test whether DNA methylation and H3K27me3 compete during T...