Research works

Meta-QTL Analysis Reveals Consensus Genomic Regions and Candidate Genes for Resistance to Sudden Death Syndrome in Soybean

Sudden death syndrome (SDS), caused by Fusarium virguliforme, is one of the most economically important diseases limiting soybean production worldwide. Although numerous quantitative trait loci (QTL) associated with SDS resistance have been reported, inconsistencies among mapping...

Early- versus Late-Window Mechanical Thrombectomy for Isolated M2/M3 Middle Cerebral Artery Occlusions: 90-Day Outcomes and Procedural Characteristics in a Single-Center Cohort

Abstract Background Randomized evidence for mechanical thrombectomy (MT) in medium vessel occlusions, particularly beyond 6 h, is heterogeneous. In a secondary analysis of a previously reported single-center cohort, we compared MT for isolated M2/M3 occlusions within versus beyon...

Association of admission LDL cholesterol with clinical profile and 3-months outcomes after ischaemic stroke

Abstract Background and aim We investigated whether admission LDL-C levels are associated with clinical profile and outcomes after acute ischaemic stroke by comparing patients stratified into five LDL-C groups. Patients and methods We retrospectively analyzed consecutively includ...

Dietary Fiber-Associated Differences in Gut Microbial Community Composition and Predicted Short-Chain Fatty Acid-Related Functional Potential: An In Silico Re-Analysis of 16S rRNA Data

Dietary fiber shapes both gut microbial community structure and the fermentable substrates available to resident taxa, yet how fiber deprivation reshapes taxonomic representation and predicted functional potential remains incompletely resolved. We performed an in silico re-analys...

Clinical Urgency of After-Hours Presentations of Dogs and Cats to a Private Small-Animal Practice in Germany: A Retrospective Study of 4579 Visits

This descriptive study aimed to assess the urgency of after-hours emergency visits in a small-animal practice using a structured triage system, and to characterize the associated presenting conditions and treatments. Medical records of 3189 dog and 1390 cat visits presented betwe...

The Ocean: A Key Earth System Regulator with Boundaries

By regulating Earth’s climate and buffering the impacts of anthropogenic pressures, the ocean plays a crucial stabilizing role in the Earth system – yet, in doing so, it is itself undergoing profound changes. This Perspective outlines the role of the ocean in the Earth system and...

Integrated Metabolomic and Transcriptomic Analysis Reveals Tissue-Specific Secondary Metabolic Differentiation and Indole Alkaloid Accumulation in Evodia rutaecarpa

Evodia rutaecarpa is a valuable medicinal plant, yet its non-medicinal tissues remain largely underexplored. Here, we integrated ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)-based widely targeted metabolomics and RNA sequencing (RNA-seq) transcrip...

Prevalence, clinical features and emergency department blood pressure management of hypertensive emergencies and uncontrolled hypertension: a retrospective multi-centre study

Abstract Very heterogeneous data have been published concerning prevalence and clinical management of Hypertensive Emergencies (HE) and Uncontrolled Hypertension (UH). The aim of our study was to characterize HE and UH patients evaluating: (i) Blood Pressure (BP) management in Em...

Radiographic outcomes of CT-based robotic-assisted versus manual direct anterior total hip arthroplasty with an acetabular-only registration workflow: a retrospective cohort study

Limited exposure through the direct anterior approach may restrict robotic registration to the acetabulum. We compared postoperative radiographic outcomes of CT-based robotic-assisted DAA THA performed with an acetabular-only bony registration workflow with manual DAA THA. This r...

Simulation-Oriented Parameterization of Virtual Human Head-Orientation Behavior Using Wearable IMU Data

Realistic head-orientation behavior contributes to the credibility of virtual human agents in scenario-based simulations. Conventional finite state machine (FSM) agents often rely on manually defined perception rules, producing repetitive head motion patterns that do not reflect...

Functional metatranscriptomics of the rhizosphere: Towards an understanding of metabolic processes of the microbial carbon pump

Abstract The soil microbiome drives soil organic carbon (SOC) transformation, shaped and impacted by plant growth stage and soil management such as tillage. The soil microbial carbon pump conceptually links the degradation of plant- and microbe-derived compounds and the neosynthe...

The Impact of Out-of-Hours Liver Transplantation on Outcomes

Objectives: This national, multicenter retrospective study of 764 adult liver transplantations (LT) in Sweden (2019–2023) employed a data-driven approach to identify the out-of-hours (OOH) high-risk window and evaluate its impact on patient outcomes and health care costs. Summary...

Urban–Rural Disparities in School Lunch Food Composition: Evidence from 12.7 Million Dish Records in Taiwan’s National School Food Registry

Background/Objectives: For many schoolchildren—particularly those in low-resource areas—the school lunch is the most reliable balanced meal of the day, so its composition is a direct determinant of dietary equity. The aim of this study was to quantify urban–rural disparities in s...

A Theory of the Earth and the Eternal Return of the Same: Nietzsche and the Geology of His Time

Abstract Nietzsche’s engagement with the natural sciences significantly shaped his philosophical ideas, contrary to Martin Heidegger’s dismissal of Nietzsche’s scientific interests as an “aberration.” While the impact of various scientific disciplines on Nietzsche’s philosophy ha...

Nutrition support in gastroenterology: opinion on current literature

Purpose of review Historically, enteral nutrition has been the preferred therapy due to its physiologic benefits, with parenteral nutrition selected if enteral nutrition was contraindicated or insufficient; however, recent advances in nutrition support have prompted reevaluation...

Cumulative TyG-related indices in relation to incident arterial stiffness and carotid intima-media thickening: a 6-year follow-up within the 36-year Hanzhong adolescent hypertension cohort

Abstract Background Insulin resistance promotes both arterial stiffening and carotid atherosclerosis, but the comparative value of TyG-related indices for these phenotypes is unclear. Using a cohort with childhood anthropometry measured in 1987, we compared two vascular phenotype...

Fostering SCALE habits of mind through AI-empowered arts-based pedagogy

Abstract The SCALE taxonomy offers a future-oriented framework of educational objectives for the age of artificial intelligence (AI). This conceptual paper asks how these objectives can be enacted through a pedagogy that remains embodied, creative, and connected to human life. We...

Optimized surgical treatment and study management for oncology patients in East Saxony (MISSION4Sax): study protocol of a multicentre pilot study

Abstract Purpose MISSION4Sax aims to develop and pilot new concepts for cross-sectoral oncological care, data integration and networking between maximum care centres and rural practitioners in medical underserved, enabling access to guideline-based therapy, innovative surgery, an...

NLRP3 Regulation in Neonatal Hypoxic–Ischemic Encephalopathy—Focus on Microglial Activation

Neonatal hypoxic–ischaemic encephalopathy (HIE) is a major cause of neonatal mortality and long-term neurological disability, affecting 1–3 per 1000 live births in developed countries and occurring at substantially higher rates in developing countries. Neuroinflammation is a key...

Integrated Analysis of Species Invasion Under the Telecoupling Framework: Burmese Python Across Southeast Asia, the USA, and Beyond

In an increasingly globalizing world, invasive species have become a serious concern worldwide. Numerous studies have focused on the biology of different invasive species, but few have systematically integrated socioeconomic and environmental factors. The framework of telecouplin...