Research works

When the Ileal Pouch Doesn’t Reach

Achieving an ileal pouch-anal anastomosis (IPAA) without tension can be difficult in cases where the mesentery doesn’t easily reach the pelvis. Risk factors for inadequate reach are discussed. Maneuvers to gain additional length for the ileal pouch to reach are reviewed, includin...

Porcine skin damage thresholds and computational modeling of continuous-wave laser exposure at 1567 nm

Continued development of high-power laser technology necessitates a robust framework for ensuring safe operation and hazard assessment. Many laser systems pertinent to atmospheric propagation applications operate in the infrared region where the potential for damage to the skin b...

Enhancing Resilience to Climate Change to Support Food Security in Vulnerable Communities Across Central Africa

Climate change remains to cripple food security across Central Africa, where a large proportion of the population depends on rain-fed agriculture survival. This study evaluated the environmental, economic, energy and agricultural factors shaping climate resilience and food securi...

Performance enhancement of domestic gas stoves through inclined burner cap ports

This work investigates numerically the effects of the inclination angle of the burner cap on the thermal performance and efficiency of liquefied petroleum gas stove. The simulations carried out using ANSYS Fluent were validated using the experimental data to ensure reliability. I...

Participant perspectives on a person-centred care model for mobile individuals in HIV care from the SEARCH Dynamic Choice Treatment trial in rural Kenya and Uganda

Introduction Mobile populations experience difficulties maintaining antiretroviral therapy (ART) adherence and HIV care engagement. We sought to explore participant perceptions of a patient-centred model aimed at enhancing care engagement through ‘dynamic choice’ treatment servic...

Outpatient Direct Initiation of Injectable Buprenorphine From Methadone: A Case Series

Objectives: Published protocols for directly initiating injectable buprenorphine from full opioid agonists (“direct-to-inject” or DTI) have largely described patients with active or recent fentanyl use. Among patients with opioid use disorder (OUD) in remission, transitioning fro...

Casimir-Robin Backreaction between Positive Anti-de Sitter (AdS4) Branes: A Semiclassical No-Go for a Static Five-Dimensional Wormhole

This preprint investigates the semiclassical backreaction generated by the Casimir effect for massless conformally coupled scalar fields confined between two positive AdS4 branes with local Robin boundary conditions in a five-dimensional Einstein-gravity background. The detuned A...

Hippocampal Seizure‐Related Burden is Associated with Accelerated Long‐Term Forgetting in Focal Epilepsy

Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified. This study in...

CSTF2 facilitates ATAD2 translation via m⁶A recognition to drive ER-positive breast cancer metabolic reprogramming and tumor progression

Abstract Objective Breast cancer (BC) is the most common malignancy among women worldwide, accounting for 11.7% of female cancer cases. Cleavage stimulation factor subunit 2 ( CSTF2 ), a key RNA-binding protein, modulates tumor development by influencing N⁶-methyladenosine (m⁶A)...

Solution and Stability of a Multi-Quadratic Functional Equation

In this paper, we characterize the general solution to a system of functional equations with respect to the multi-quadratic mappings by proving that any such mapping can be uniquely represented via a 2n-additive pairwise symmetric mapping. And we prove the stability results with...

O-Glycosylated Oncofetal Fibronectin Expression in Lesions of Human Cutaneous Leishmaniasis: A Novel Finding in Infectious Diseases

Cutaneous leishmaniasis (CL) is a chronic infectious disease characterized by extensive tissue destruction and profound extracellular matrix (ECM) remodeling. This study provides the first evidence of O-glycosylated oncofetal fibronectin (onf-FN) expression in human CL lesions. I...

Farm Input Subsidies and Energy Poverty: Evidence From Malawi

ABSTRACT Farm input subsidies in sub‐Saharan Africa are widely recognised for their role in reducing income poverty by improving household incomes. However, their spillover effects to non income‐based poverty receives comparatively less attention, despite the potential. Using dat...

Microstructure and Properties of Eu-Ni Alloys Prepared by Levitation Melting

With the rapid development of the nuclear power industry, the requirement for nuclear structural materials is continuously growing. Eu-Ni intermetallic alloys are promising structural candidates for nuclear applications, while relevant fundamental investigations and underlying me...

Metal‐Organic Framework‐Templated Deconstruction‐Reconstruction Enables One‐Dimensional to Two‐Dimensional Self‐Assembly of Transition Metal Phosphates for High‐Performance Ammonia Sensing

ABSTRACT Self‐assembled nanomaterials formed through the spontaneous organisation of nanoscale building blocks are attractive because of their high surface areas, strong interparticle connectivity, and ease of processing. However, programming the assembly of one‐dimensional (1D)...

BeVerA-KG: Behaviour-Driven Design-Time Verification of Neuro-Symbolic Agents via Knowledge Graphs for Trustworthy Humanitarian Edge Systems

Runtime guardrails for LLM agents enforce safety per individual action at execution time, but fail to verify the reachable state space before deployment. We present BeVerA-KG, a behaviour-driven framework that shifts verification to design time. Stakeholder-authored Gherkin scena...

Village chickens enhance food security and income for vulnerable groups along the urban-rural gradient, a scoping review

Abstract A sustainable and healthy food system refers to meeting food and nutrition security and environmental welfare for all, with no cost to future generations. Village chickens promote sustainable and healthy food systems through recycling home-kitchen waste into edible prote...

A novel ZEB1 splice-site variant causing early-onset type 3 posterior polymorphous corneal dystrophy and suspected corneal ectasia

Posterior polymorphous corneal dystrophy type 3 (PPCD3) is an autosomal dominant endothelial dystrophy caused by variations in the ZEB1 gene. We report a pediatric case presenting with progressive visual impairment associated with simultaneous features of corneal ectasia and endo...

Triality-Symmetric Phi-Entanglement: Self-Healing Resonance via E8's Order-3 Outer Automorphism — E8 Intelligence Research

The SO(8) triality automorphism partitions the 240 E8 root vectors into three 80-vector sectors corresponding to the vector and two spinor representations. When these triality sectors are embedded in a phi-scaled recursive lattice at 132Hz, the golden-ratio coupling establishes p...

Manganese Carbonyl-Based Peroxidase-like Nanoenzyme Cascading with Glucose Oxidase, Combined with Porphyrin-COFs-Based Phototherapy and CO-Mediated Immunomodulation for Diabetic Wound Repair

Abstract Diabetic wounds remain a global health challenge due to vascular insufficiency, bacterial infection, and persistent inflammation. Herein, we designed and prepared a triple-synergistic nanoenzyme platform with antibacterial, anti-inflammatory, and angiogenesis-promoting e...

Adverse birth outcome and associated factors among women who gave birth in hospitals of East Gurage Zone, Central Ethiopia: multicenter cross sectional study

Adverse birth outcome are the most common and major public health concerns globally and their prevalence is high, especially in low and middle-income countries. Despite the Ethiopian healthcare policy, which tried to transform the healthcare system to reduce and prevent adverse b...